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Open-Access Journal
Editorial
Current understanding of the functional roles of aberrantly expressed microRNAs in esophageal cancer 
Christine Kestens, Peter D Siersema, Jantine WPM van Baal 
World J Gastroenterol 22(1):1-7. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.1
Topic Highlight
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination? 
Moon-Sun Kim, Madeleine Ong, Xianqin Qu 
World J Gastroenterol 22(1):8-23. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.8
Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease 
Fernando Ezquer, Flavia Bruna, Sebastián Calligaris, Paulette Conget, Marcelo Ezquer 
World J Gastroenterol 22(1):24-36. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.24
Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes 
Kyu-Ho Han, Naoto Hashimoto, Michihiro Fukushima 
World J Gastroenterol 22(1):37-49. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.37
Metabolic derivatives of alcohol and the molecular culprits of fibro-hepatocarcinogenesis: Allies or enemies? 
Alex Boye, Yu-Hong Zou, Yan Yang 
World J Gastroenterol 22(1):50-71. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.50
Molecular changes in hepatic metabolism and transport in cirrhosis and their functional importance 
Christoph G Dietrich, Oliver Götze, Andreas Geier 
World J Gastroenterol 22(1):72-88. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.72
Four-dimensional flow magnetic resonance imaging in cirrhosis 
Zoran Stankovic 
World J Gastroenterol 22(1):89-102. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.89
Magnetic resonance imaging of the cirrhotic liver in the era of gadoxetic acid 
Francesco Agnello, Marco Dioguardi Burgio, Dario Picone, Federica Vernuccio, Giuseppe Cabibbo, Lydia Giannitrapani, Adele Taibbi, Antonino Agrusa, Tommaso Vincenzo Bartolotta, Massimo Galia, Roberto Lagalla, Massimo Midiri, Giuseppe Brancatelli 
World J Gastroenterol 22(1):103-111. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.103
Left ventricular function assessment in cirrhosis: Current methods and future directions 
Francisco Sampaio, Joana Pimenta 
World J Gastroenterol 22(1):112-125. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.112
Genetic variation of hepatitis B virus and its significance for pathogenesis 
Zhen-Hua Zhang, Chun-Chen Wu, Xin-Wen Chen, Xu Li, Jun Li, Meng-Ji Lu 
World J Gastroenterol 22(1):126-144. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.126
Overview of hepatitis B virus mutations and their implications in the management of infection 
Patrizia Caligiuri, Rita Cerruti, Giancarlo Icardi, Bianca Bruzzone 
World J Gastroenterol 22(1):145-154. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.145
Association between hepatitis B and metabolic syndrome: Current state of the art 
Peter Jarcuska, Sylvia Drazilova, Jan Fedacko, Daniel Pella, Martin Janicko 
World J Gastroenterol 22(1):155-164. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.155
Prophylactic managements of hepatitis B viral infection in liver transplantation 
Takashi Onoe, Hiroyuki Tahara, Yuka Tanaka, Hideki Ohdan 
World J Gastroenterol 22(1):165-175. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.165
Autophagy and microRNA in hepatitis B virus-related hepatocellular carcinoma 
Shan-Ying Wu, Sheng-Hui Lan, Hsiao-Sheng Liu 
World J Gastroenterol 22(1):176-187. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.176
Advances in computed tomography and magnetic resonance imaging of hepatocellular carcinoma 
Tiffany Hennedige, Sudhakar K Venkatesh 
World J Gastroenterol 22(1):205-220. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.205
Molecular imaging and therapy targeting copper metabolism in hepatocellular carcinoma 
Jason Wachsmann, Fangyu Peng 
World J Gastroenterol 22(1):221-231. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.221
Prediction of hepatocellular carcinoma biological behavior in patient selection for liver transplantation 
Umberto Cillo, Tommaso Giuliani, Marina Polacco, Luz Maria Herrero Manley, Gino Crivellari, Alessandro Vitale 
World J Gastroenterol 22(1):232-252. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.232
Current status and perspectives of immune-based therapies for hepatocellular carcinoma 
Maridi Aerts, Daphné Benteyn, Hans Van Vlierberghe, Kris Thielemans, Hendrik Reynaert 
World J Gastroenterol 22(1):253-261. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.253
Controversies regarding and perspectives on clinical utility of biomarkers in hepatocellular carcinoma 
Pei-Pei Song, Ju-Feng Xia, Yoshinori Inagaki, Kiyoshi Hasegawa, Yoshihiro Sakamoto, Norihiro Kokudo, Wei Tang 
World J Gastroenterol 22(1):262-274. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.262
Glypican-3 is a prognostic factor and an immunotherapeutic target in hepatocellular carcinoma 
Yukihiro Haruyama, Hiroaki Kataoka 
World J Gastroenterol 22(1):275-283. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.275
Differentiation of hepatocellular carcinoma from its various mimickers in liver magnetic resonance imaging: What are the tips when using hepatocyte-specific agents? 
Yang Shin Park, Chang Hee Lee, Jeong Woo Kim, Sora Shin, Cheol Min Park 
World J Gastroenterol 22(1):284-299. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.284
Hepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes 
Yuan-Chi Teng, Zhao-Qing Shen, Cheng-Heng Kao, Ting-Fen Tsai 
World J Gastroenterol 22(1):300-325. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.300
Targeting adeno-associated virus and adenoviral gene therapy for hepatocellular carcinoma 
Yi-Gang Wang, Pan-Pan Huang, Rong Zhang, Bu-Yun Ma, Xiu-Mei Zhou, Yan-Fang Sun 
World J Gastroenterol 22(1):326-337. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.326
Review
Xenobiotics and loss of tolerance in primary biliary cholangitis 
Jinjun Wang, Guoxiang Yang, Alana Mari Dubrovsky, Jinjung Choi, Patrick SC Leung 
World J Gastroenterol 22(1):338-348. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.338
Combination antiretroviral studies for patients with primary biliary cirrhosis 
Ellina Lytvyak, Aldo J Montano-Loza, Andrew L Mason 
World J Gastroenterol 22(1):349-360. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.349
Gut microbiota in autism and mood disorders 
Francesca Mangiola, Gianluca Ianiro, Francesco Franceschi, Stefano Fagiuoli, Giovanni Gasbarrini, Antonio Gasbarrini 
World J Gastroenterol 22(1):361-368. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.361
Proteoglycans in liver cancer 
Kornélia Baghy, Péter Tátrai, Eszter Regős, Ilona Kovalszky 
World J Gastroenterol 22(1):379-393. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.379
Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents 
Hiroyasu Sakai, Yohei Shirakami, Masahito Shimizu 
World J Gastroenterol 22(1):394-406. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.394
Treatment of hepatocellular carcinoma with portal venous tumor thrombosis: A comprehensive review 
Kichang Han, Jin Hyoung Kim, Gi-Young Ko, Dong Il Gwon, Kyu-Bo Sung 
World J Gastroenterol 22(1):407-416. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.407
Minireviews
Nuclear magnetic resonance based metabolomics and liver diseases: Recent advances and future clinical applications 
Roland Amathieu, Mohamed Nawfal Triba, Corentine Goossens, Nadia Bouchemal, Pierre Nahon, Philippe Savarin, Laurence Le Moyec 
World J Gastroenterol 22(1):417-426. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.417
Solid, non-skin, post-liver transplant tumors: Key role of lifestyle and immunosuppression management 
Christophe Carenco, Stéphanie Faure, José Ursic-Bedoya, Astrid Herrero, Georges Philippe Pageaux 
World J Gastroenterol 22(1):427-434. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.427
Endoscopic submucosal tunnel dissection for large superficial esophageal squamous cell neoplasms 
Ya-Qi Zhai, Hui-Kai Li, En-Qiang Linghu 
World J Gastroenterol 22(1):435-445. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.435
Systematic Reviews
Distinctive aspects of peptic ulcer disease, Dieulafoy's lesion, and Mallory-Weiss syndrome in patients with advanced alcoholic liver disease or cirrhosis 
Borko Nojkov, Mitchell S Cappell 
World J Gastroenterol 22(1):446-466. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.446