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Copyright ©The Author(s) 2016.
World J Gastroenterol. Jan 7, 2016; 22(1): 72-88
Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.72
Table 1 Typical clinical applications for the quantitative assessment of hepatic function by means of 13C-labeled compounds as breath test substrates
Investigated function13C-labelled compound
Bile acid malabsorptionGlycocholic acid
Hepatic microsomal function (CYP P450)Aminopyrine, methacetin, phenacetin caffeine, diazepam, erythromycin
Hepatic cytosolic function (galactokinase)Galactose, phenylalanine
Hepatic mitochondrial function (α-keto acid dehydrogenase complex)Methionine, octanoate, α-ketoisocaproic acid
Table 2 Established scores or criteria for treatment decisions in hepatology, some criteria are used with different parameters in different countries
NameParametersUsed for
MELD[163]INR, creatinine, bilirubinCLF, LTX, resection
Child Pugh[164]Prothrombin time, bilirubin, ascites, encephal., albuminCLF, resection
King’s College[165]Paracetamol-ALF: pH, INR, creatinine, encephalALF, LTX
Non-paracetamol-ALF: INR, age, bilirubin, timing of jaundice, etiology
Clichy[165]Age, factor V, encephalopathyALF, LTX
Milano[166]Size and number of tumor nodulesHCC, LTX