Welcome to World Journal of Gastroenterology


The World Journal of Gastroenterology (WJG) is an academic journal that publishes review articles and articles describing original research (basic or clinical) in the fields of gastroenterology, hepatology, gastrointestinal surgery, and gastrointestinal endoscopy. With the aim of advancing knowledge in each of these fields, the WJG gives topical priority to related major diseases and their clinical management; frequently published disease topics are gastric cancer, colorectal cancer, hepatocellular carcinoma, pancreatic cancer, inflammatory bowel disease, irritable bowel syndrome, hepatitis C, hepatitis B, nonalcoholic fatty liver disease, and liver transplantation. All articles published in the WJG comply with the Code of Conduct of the Committee on Publication Ethics (COPE) and the requirements of Academic Rules and Norms. No restrictions are imposed on numbers of words, figures (color, B/W), tables or references for any articles published in the WJG, allowing authors to tell a whole story. The WJG readership audience is global, representing 218 countries and regions, with an average number of 55,000 visits to the online journal per day. For details, please see http://www.wjgnet.com/1007-9327/VisitStatistics.aspx.


We encourage gastroenterologists and hepatologists worldwide to submit manuscripts to the WJG describing their original basic or clinical research findings that are of high academic value and which report new diagnostic techniques or summarize their treatment experiences.


The usual times related to all publication processes of the WJG are as follows: (1) From manuscript receipt to peer-review: 2-4 weeks; (2) From initial manuscript acceptance, with revisions, to return of the revised manuscript from the authors: 4-5 weeks; (3) From return of the revised manuscript from the authors to final acceptance: 1-2 weeks; (4) From final acceptance to an article in press: 2 days; and (5) From article in press designation to formal release of the electronic version and all online documentation: 2-9 weeks. The WJG’s acceptance rate: 35%. Submit here >>

Published Issues
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Geoffrey Burnstock, DSc, FAA, FRCS(Hon), FRS, PhD, Professor; Hugh Freeman, FACG, FACP, FRCP(C), MD, Professor; Damian Garcia-Olmo, MD, PhD, Doctor, Professor, Surgeon; Stephen Strom, PhD, Professor; Andrzej Tarnawski, DSc, MD, PhD, Professor


Science Citation Index Expanded(Web of Science), Current Contents/Clinical Medicine, Journal Citation Reports, Index Medicus, MEDLINE, PubMed, and PubMed Central.

Impact Factor

2.369/2014, 2.671/5 year (Data from the 2014 edition of Journal Citation Reports®).


1007-9327 (print) and 2219-2840 (online)

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Contents Volume 22  Issue 18  May 14, 2016
Topic Highlight
Thrombin activation and liver inflammation in advanced hepatitis C virus infection  
Emilio González-Reimers, Geraldine Quintero-Platt, Candelaria Martín-González, Onán Pérez-Hernández, Lucía Romero-Acevedo, Francisco Santolaria-Fernández
World J Gastroenterol 22(18):4427-4437. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4427
Liver transplantation: Current status and challenges  
Caroline C Jadlowiec, Timucin Taner
World J Gastroenterol 22(18):4438-4445. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4438
Advances in inducing adaptive immunity using cell-based cancer vaccines: Clinical applications in pancreatic cancer  
Mikio Kajihara, Kazuki Takakura, Tomoya Kanai, Zensho Ito, Yoshihiro Matsumoto, Shigetaka Shimodaira, Masato Okamoto, Toshifumi Ohkusa, Shigeo Koido
World J Gastroenterol 22(18):4446-4458. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4446
Combined hepatocellular cholangiocarcinoma: Controversies to be addressed  
An-Qiang Wang, Yong-Chang Zheng, Juan Du, Cheng-Pei Zhu, Han-Chun Huang, Shan-Shan Wang, Liang-Cai Wu, Xue-Shuai Wan, Hao-Hai Zhang, Ruo-Yu Miao, Xin-Ting Sang, Hai-Tao Zhao
World J Gastroenterol 22(18):4459-4465. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4459
Basic Study
Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma: Characterization in a 3D-cell culture model  
Nicoletta Gagliano, Giuseppe Celesti, Lorenza Tacchini, Stefano Pluchino, Chiarella Sforza, Marco Rasile, Vincenza Valerio, Luigi Laghi, Vincenzo Conte, Patrizia Procacci
World J Gastroenterol 22(18):4466-4483. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4466
Role of estrogen receptor β selective agonist in ameliorating portal hypertension in rats with CCl4-induced liver cirrhosis  
Cheng-Gang Zhang, Bin Zhang, Wen-Sheng Deng, Ming Duan, Wei Chen, Zhi-Yong Wu
World J Gastroenterol 22(18):4484-4500. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4484
miR-30b inhibits autophagy to alleviate hepatic ischemia-reperfusion injury via decreasing the Atg12-Atg5 conjugate  
Shi-Peng Li, Jin-Dan He, Zhen Wang, Yao Yu, Shu-Yu Fu, Hai-Ming Zhang, Jian-Jun Zhang, Zhong-Yang Shen
World J Gastroenterol 22(18):4501-4514. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4501
Dissecting characteristics and dynamics of differentially expressed proteins during multistage carcinogenesis of human colorectal cancer  
Fang Peng, Ying Huang, Mao-Yu Li, Guo-Qing Li, Hui-Chao Huang, Rui Guan, Zhu-Chu Chen, Song-Ping Liang, Yong-Heng Chen
World J Gastroenterol 22(18):4515-4528. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4515
Elevated serum interleukin-38 level at baseline predicts virological response in telbivudine-treated patients with chronic hepatitis B  
Hong-Juan Wang, Yan-Fang Jiang, Xin-Rui Wang, Man-Li Zhang, Pu-Jun Gao
World J Gastroenterol 22(18):4529-4537. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4529
Expression of B7-H4 and hepatitis B virus X in hepatitis B virus-related hepatocellular carcinoma  
Bo Hong, Yun Qian, Hong Zhang, Yi-Wen Sang, Lin-Fang Cheng, Qi Wang, Song Gao, Min Zheng, Hang-Ping Yao
World J Gastroenterol 22(18):4538-4546. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4538
Retrospective Cohort Study
Predictive factors for survival and score application in liver retransplantation for hepatitis C recurrence  
Alice Tung Wan Song, Rodolphe Sobesky, Carmen Vinaixa, Jérôme Dumortier, Sylvie Radenne, François Durand, Yvon Calmus, Géraldine Rousseau, Marianne Latournerie, Cyrille Feray, Valérie Delvart, Bruno Roche, Stéphanie Haim-Boukobza, Anne-Marie Roque-Afonso, Denis Castaing, Edson Abdala, Luiz Augusto Carneiro D’Albuquerque, Jean-Charles Duclos-Vallée, Marina Berenguer, Didier Samuel
World J Gastroenterol 22(18):4547-4558. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4547
Retrospective Study
Video capsule endoscopy in left ventricular assist device recipients with obscure gastrointestinal bleeding  
Surachai Amornsawadwattana, Michael Nassif, David Raymer, Shane LaRue, Chien-Huan Chen
World J Gastroenterol 22(18):4559-4566. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4559
Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia  
Roberto Herrera-Goepfert, Luis F Oñate-Ocaña, José Luis Mosqueda-Vargas, Luis A Herrera, Clementina Castro, Julia Mendoza, Rodrigo González-Barrios
World J Gastroenterol 22(18):4567-4575. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4567
Correlation between Helicobacter pylori-associated gastric diseases and colorectal neoplasia  
Ying Qing, Min Wang, Ying-Min Lin, Dong Wu, Jing-Yu Zhu, Lang Gao, Yan-Yan Liu, Teng-Fei Yin
World J Gastroenterol 22(18):4576-4584. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4576
Observational Study
Changes in patients’ symptoms and gastric emptying after Helicobacter pylori treatment  
Chun-Ling Zhang, Chang-Hui Geng, Zhi-Wei Yang, Yan-Lin Li, Li-Quan Tong, Ping Gao, Yue-Qiu Gao
World J Gastroenterol 22(18):4585-4593. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4585
Systematic Reviews
Calcium supplementation for the prevention of colorectal adenomas: A systematic review and meta-analysis of randomized controlled trials  
Stefanos Bonovas, Gionata Fiorino, Theodore Lytras, Alberto Malesci, Silvio Danese
World J Gastroenterol 22(18):4594-4603. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4594
Case Report
Pseudo-Meigs’ syndrome secondary to metachronous ovarian metastases from transverse colon cancer  
Kennoki Kyo, Atsushi Maema, Motoaki Shirakawa, Toshio Nakamura, Kenji Koda, Hidetaro Yokoyama
World J Gastroenterol 22(18):4604-4609. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4604
Isolated splenic metastasis from colon cancer: Case report  
Jiddou Abdou, Youssef Omor, Saber Boutayeb, Basma Elkhannoussi, Hassan Errihani
World J Gastroenterol 22(18):4610-4614. Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4610