Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.72
Peer-review started: May 8, 2015
First decision: August 25, 2015
Revised: September 24, 2015
Accepted: November 13, 2015
Article in press: November 13, 2015
Published online: January 7, 2016
Core tip: Liver cirrhosis is a common endpoint for many hepatic diseases and is accompanied by the extensive gene regulation of cytokines and enzymes for hepatic metabolism. The resulting organ deficiency complicates treatment decisions, especially regarding transplantation and the resection of hepatocellular carcinoma. This review summarizes the regulatory events involving the metabolism in the cirrhotic liver and puts these events into the context of the non-invasive testing of liver function. This combination can help to better estimate the liver function of individual patients.