Baishideng Publishing Group

Tian QJ, Zhang LJ, Zhang Q, Liu FC, Xie M, Cai JZ, Rao W. Protein-losing enteropathy and multiple vasculature dysplasia in LZTR1-related Noonan syndrome: A case report and review of literature. World J Gastroenterol 2025; 31(17): 105347

"I think your journal is very good in processing speed. It is easy and smooth to operate the submission system. The peer review process ..." [Read more]

"I think your journal is very good in processing speed. It is easy and smooth to operate the submission system. The peer review process is fast and excellent. The reviewer comments are of high quality. The publication after acceptance of the mansucript is very fast. I am very satistifed with any dimensions of your journal. Thanks for your kind work. " [Collapse]

Zhao CY, Xu N, Dong H, Chai NL, Linghu EQ. Effect of sex on the outcomes of peroral endoscopic myotomy for the treatment of achalasia. World J Gastroenterol 2025; 31(17): 104579

"The World Journal of Gastroenterology maintains a high academic standard in the research of gastrointestinal diseases and continues ..." [Read more]

"The World Journal of Gastroenterology maintains a high academic standard in the research of gastrointestinal diseases and continues to improve. During the review process, the comments provided by the reviewers are scientific and reasonable, which greatly enhances the quality of the manuscripts. From the submission of the manuscript to its official online publication, we truly appreciate the dedicated and responsible attitude of the entire editorial team, including assistant editors, scientific editors, peer reviewers, the editor-in-chief, the company's editor-in-chief, language editors, and production editors, in handling the manuscripts, which ensures their quality. In the future, we will continue to submit high-quality manuscripts to the World Journal of Gastroenterology. " [Collapse]

Zhao CF, Liu XL, Wu NB, Xu ZF. Triglyceride-glucose index as a prognostic indicator in advanced gastric cancer: Insights and future research. World J Gastroenterol 2025; 31(17): 104794

"I am very grateful to the journal for accepting my manuscript. The article has been reviewed several times by reviewers, and I have ..." [Read more]

"I am very grateful to the journal for accepting my manuscript. The article has been reviewed several times by reviewers, and I have made many revisions. In the process of submission, I felt the review experts and editorial staff of the rigorous and serious style of work. In a word, I'm very satisfied. " [Collapse]

Lv SP, Qin LL, Mou H, Huang T, Wang KQ. Multimodal imaging techniques for the diagnosis of congenital left renal arteriovenous fistula: A case report. World J Clin Cases 2025; 13(21): 104062

"Evaluation of the Journal's Credibility The World Journal of Gastroenterology maintains high academic standards and demonstrates a ..." [Read more]

"Evaluation of the Journal's Credibility The World Journal of Gastroenterology maintains high academic standards and demonstrates a rigorous commitment to advancing gastrointestinal research. The journal’s reputation is well-established within the scientific community, supported by its inclusion in prominent databases and adherence to transparent editorial practices. The clarity of submission guidelines and ethical publishing policies further reinforce its credibility. Evaluation of the Journal’s Peer Review Process The peer review process was both thorough and constructive. Reviewers provided detailed, actionable feedback that significantly strengthened the manuscript. The editorial team ensured timely communication at every stage, and the double-blind review system upheld fairness and impartiality. However, a slightly faster turnaround time for initial reviews could further enhance author experience. General Comments The collaborative efforts of the editorial team—including language editors, production staff, and peer reviewers—were instrumental in refining the manuscript. The F6Publishing platform is user-friendly, and the support from the editorial office was consistently professional and responsive. We appreciate the journal’s dedication to open access, which maximizes the visibility and impact of published work. A minor suggestion would be to expand the scope of author resources (e.g., detailed formatting templates or video tutorials) to assist first-time submitters. Final Remarks Publishing with World Journal of Gastroenterology has been a positive and rewarding experience. We commend the journal for its efficiency, transparency, and commitment to scientific excellence. This collaboration has encouraged us to consider submitting future work to the journal. " [Collapse]

Wu YP, Zhou JX, Wu HB, Wu DP, Qin LZ, Qin B, Xu XY, Yehya SAA, Cheng Y. Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study. World J Gastroenterol 2025; 31(17): 105281

"The World Journal of Gastroenterology demonstrated exceptional efficiency in handling our article and managing the publication process. ..." [Read more]

"The World Journal of Gastroenterology demonstrated exceptional efficiency in handling our article and managing the publication process. Their streamlined approach, prompt communication, and thorough peer review ensured a smooth journey from submission to publication. The journal's commitment to timely dissemination of research was evident in their rapid turnaround times and professional editorial support, enhancing the overall publication experience for authors. " [Collapse]

Gadour E, AlQahtani MS. Illuminating the black box: Machine learning enhances preoperative prediction in intrahepatic cholangiocarcinoma. World J Gastroenterol 2025; 31(17): 106592

"We are highly satisfied with the overall process of publication and peer review. The prepared tables in the online full-text article ..." [Read more]

"We are highly satisfied with the overall process of publication and peer review. The prepared tables in the online full-text article were clear, accurate, and well-organized, reflecting the quality of the journal’s editing standards. We appreciated the adherence to academic rules and norms throughout the process. Furthermore, the peer review was conducted anonymously, fairly, and objectively, providing valuable feedback that helped us significantly improve our manuscript. The period of publication was reasonable, and the detection report for academic misconduct added transparency and credibility. Overall, we are pleased with the professional and efficient handling of our submission. " [Collapse]

Karagiannidis E, Papazoglou AS, Samaras A, Nasoufidou A, Zormpas G, Tagarakis G, Theodoropoulos KC, Papadakis M, Tzikas A, Fragakis N, Kassimis G. Intravascular ULTRA sound-guided percutaneous coronary intervention in patients with STEMI: Rationale and design of the ULTRA-STEMI trial. World J Cardiol 2025; 17(4): 106072

"Thank you for always recommending reviewers for me, even though it has taken more than a year. However, the publication fee of the ..." [Read more]

"Thank you for always recommending reviewers for me, even though it has taken more than a year. However, the publication fee of the journal is too high. I made great efforts to get this sum of money reimbursed. I hope that the publication fee of the journal can be reduced in the future. " [Collapse]

Ye XW, Zhang HX, Li Q, Li CS, Zhao CJ, Xia LJ, Ren HM, Wang XX, Yang C, Wang YJ, Jiang SL, Xu XF, Li XR. Scientometric analysis and historical review of diabetic encephalopathy research: Trends and hotspots (2004-2023). World J Diabetes 2025; 16(5): 91200

"I am deeply grateful for the outstandingly high - efficiency work of the journal. Also, the reviewers' comments are of great value. ..." [Read more]

"I am deeply grateful for the outstandingly high - efficiency work of the journal. Also, the reviewers' comments are of great value. Their constructive suggestions provide us with new perspectives and insights to improve our work. Once again, I would like to express our sincere gratitude for publishing this letter. " [Collapse]

Wei H, Mai ZL, Ma BT, Chang B. Creeping fat: A promising radiological predictor in small bowel Crohn’s disease. World J Gastroenterol 2025; 31(16): 105186

"The review speed of the article is impressively fast, with the editorial team ensuring a smooth and efficient submission-to-publication ..." [Read more]

"The review speed of the article is impressively fast, with the editorial team ensuring a smooth and efficient submission-to-publication process. The review experts provide highly professional and insightful opinions, offering constructive feedback that significantly enhances the quality of the manuscript. Their expertise and attention to detail are truly commendable. Additionally, the editor responsible for formatting and correcting the article in the later stage is exceptionally diligent, responsible, and patient. They meticulously check every detail, from grammar and punctuation to formatting consistency, ensuring the final version meets the highest academic standards. Their dedication and thoroughness greatly contribute to the polished and professional presentation of the work. Overall, the entire team's commitment to excellence makes the publication process both pleasant and rewarding for authors. " [Collapse]

Xu XT, Jiang MJ, Fu YL, Xie F, Li JJ, Meng QH. Incidence and efficacy of strategies for preventing hepatic encephalopathy following transjugular intrahepatic portosystemic shunt: A meta-analysis. World J Hepatol 2025; 17(4): 104890

"I am very satisfied with the excellent publishing services provided by Best Publishing Group in all aspects. The evaluation process ..." [Read more]

"I am very satisfied with the excellent publishing services provided by Best Publishing Group in all aspects. The evaluation process is fair and transparent, and I hope that our future research papers can be published in professional journals under the publishing group. Wishing your company continued success and serving more researchers and readers " [Collapse]

Lei XT, Chen XF, Qiu S, Tang JY, Geng S, Yang GY, Wu QN. TERT/FOXO1 signaling promotes islet β-cell dysfunction in type 2 diabetes mellitus by regulating ATG9A-mediated autophagy. World J Diabetes 2025; 16(5): 102994

"The online process for publishing the manuscript was satisfactory and the peer review was ok, even though I took a little more time ..." [Read more]

"The online process for publishing the manuscript was satisfactory and the peer review was ok, even though I took a little more time than usually. The one thing that really annoyed us and especialy me as a correspondant author was the editing of the manuscript,with too many back and forth for minor revisions, that was time consuming and tiring. " [Collapse]

Sakellariou E, Argyropoulou E, Galanis A, Rozis M, Zachariou D, Varsamos I, Parchas N, Kalavrytinos D, Karampinas P, Vasiliadis ES, Vlamis J, Pneumaticos S. Life-threatening vascular injury in an elderly patient with isolated pubic ramus fracture: A case report. World J Clin Cases 2025; 13(21): 103786

"The overall experience of publishing articles in this system is very good, and the editing teacher has given a lot of guidance and ..." [Read more]

"The overall experience of publishing articles in this system is very good, and the editing teacher has given a lot of guidance and help. I am very satisfied with all the processes of publishing articles. Thank you very much. I wish this magazine would publish more and more high-quality articles. Thands again. " [Collapse]

Lai YF, Liang ZM, Li JF, Zhang JY, Xu DH, Dai HY. Spectral computed tomography parameters of primary tumors and lymph nodes for predicting tumor deposits in colorectal cancer. World J Radiol 2025; 17(4): 103359

"The article was reviewed quickly and the opinions of the reviewers were fair, which was very helpful to us. It is recommended to avoid ..." [Read more]

"The article was reviewed quickly and the opinions of the reviewers were fair, which was very helpful to us. It is recommended to avoid including experts from the same institution as the author as reviewers when seeking reviewers for subsequent articles, in order to avoid affecting the publication process of the article " [Collapse]

Yu JW, Zhao Q, Li PX, Zhang YX, Gao BX, Xiang LB, Liu XY, Wang L, Sun YJ, Yang ZZ, Shi YJ, Chen YF, Yu MB, Zhang HK, Zhang L, Xu QH, Ren L, Li D, Lyu Y, Ren FG, Lu Q. Duodenal mucosal ablation with irreversible electroporation reduces liver lipids in rats with non-alcoholic fatty liver disease. World J Gastroenterol 2025; 31(16): 105188

"We are delighted to submit our manuscript to World Journal of diabetes and express our sincere gratitude for the opportunity to share ..." [Read more]

"We are delighted to submit our manuscript to World Journal of diabetes and express our sincere gratitude for the opportunity to share our research through your esteemed platform. From the initial submission process to the insightful feedback provided by the reviewers, we have been thoroughly impressed by the journal’s professionalism, efficiency, and commitment to academic excellence. The constructive comments received have significantly enhanced the quality of our work, and we are confident that the journal’s rigorous peer-review process ensures the publication of high-caliber research that advances our field. We appreciate the journal’s rapid turnaround time and transparent communication, which have made the submission experience both smooth and rewarding. The editorial team’s attention to detail and dedication to maintaining the highest standards in scientific publishing are truly commendable. It is an honor to be part of a journal that not only disseminates cutting-edge research but also fosters a collaborative environment for scholars to engage and contribute to academic discourse. " [Collapse]

Jiang Q, Hu Y, Ma JH. Various classification methods for diabetes mellitus in the management of blood glucose control. World J Diabetes 2025; 16(5): 103316

"Publishing with this journal was a fantastic experience. The editorial team was professional, responsive, and supportive throughout ..." [Read more]

"Publishing with this journal was a fantastic experience. The editorial team was professional, responsive, and supportive throughout every stage of the process. Peer reviews were thorough, thoughtful, and constructive, helping to significantly strengthen the final manuscript. The entire timeline, from submission to publication, was smooth and efficient. I highly recommend this journal to fellow researchers and colleagues seeking a positive publishing experience. " [Collapse]

Jerez Diaz D, Twohig P. Deadly intersection: Schistosomiasis, hepatopulmonary syndrome, and cirrhosis. World J Hepatol 2025; 17(4): 105583

"Thank you for the opportunity to have our manuscript published in World Journal of Hepatology. The peer review process was very ..." [Read more]

"Thank you for the opportunity to have our manuscript published in World Journal of Hepatology. The peer review process was very adequate, although I might suggest that the time for finishing this process could be shorter. I understand the difficulty of finding an adequate reviewer, but it would be interesting if we could have a shorter interval between submission and acceptance ( or a refuse answer). Overall, it was a good experience to submit our article to WJH. " [Collapse]

Agoglia L, Chindamo MC, Villela-Nogueira C. Psoriasis, metabolic syndrome and methotrexate: Is this association suitable for a new subcategory in steatotic liver disease? World J Hepatol 2025; 17(4): 102978

"In general, this journal maintains high standards of academic rigor and ensures transparency in its operations. The editorial team’s ..." [Read more]

"In general, this journal maintains high standards of academic rigor and ensures transparency in its operations. The editorial team’s commitment to maintaining quality is reflected in their meticulous review practices, which ensure the publication of impactful research. Overall, this journal and its peer-review system are good enough, no further comments. " [Collapse]

Liu N, Yan WT, Xiong K. Plantamajoside: A potentially novel botanical agent for diabetes mellitus management. World J Diabetes 2025; 16(5): 104311

"The time delays in peer reviews and acceptance are a big concern as that will reduce the impact of the paper. Recently the delays ..." [Read more]

"The time delays in peer reviews and acceptance are a big concern as that will reduce the impact of the paper. Recently the delays in peer review process is to long possibly from AI generated peer review invitations and I often miss these invitations in my emails unless I regularly check the F6Publishing platform. Thanks, Professor Joseph M Pappachan, MD, FRCP " [Collapse]

Kamrul-Hasan ABM, Ganakumar V, Nagendra L, Dutta D, Islam MR, Pappachan JM. Effect of beinaglutide, a thrice-daily GLP-1 receptor agonist, on body weight and metabolic parameters: A systematic review and meta-analysis. World J Diabetes 2025; 16(5): 103244

"The time delays in peer reviews and acceptance are a big concern as that will reduce the impact of the paper. Recently the delays ..." [Read more]

Bhattacharya S, Fernandez CJ, Kamrul-Hasan ABM, Pappachan JM. Monogenic diabetes: An evidence-based clinical approach. World J Diabetes 2025; 16(5): 104787

18576 items Read more >>

Article Quality Tracking-Peer-Review

"1. Is the patient's age compatible with the diagnosis of congenital renal arteriovenous fistula? What is the common age group for ..." [Read more]

"1. Is the patient's age compatible with the diagnosis of congenital renal arteriovenous fistula? What is the common age group for a typical congenital RAVF? 2. Instead of summarising the details of the case under the conclusion, a 'take home' message including when to suspect, what to do can be helpful for the reader." [Collapse]

Lv SP, Qin LL, Mou H, Huang T, Wang KQ. Multimodal imaging techniques for the diagnosis of congenital left renal arteriovenous fistula: A case report. World J Clin Cases 2025; 13(21): 104062

"1. The introduction section is lengthy and packed with information. The purpose of the introduction is to inform the reader about ..." [Read more]

"1. The introduction section is lengthy and packed with information. The purpose of the introduction is to inform the reader about the background, which can be a brief overview rather than an exhaustive one. 2. The discussion can include the cost and other potential limitations of circulating tumor DNA. 3. The likely future prospects such as need for a multicentre / institutional prospective randomised trial can be included in the discussion. " [Collapse]

Zhou XY, Jiang YJ, Guo XM, Han DH, Liu Y, Qiao Q. Application of circulating tumor DNA liquid biopsy in nasopharyngeal carcinoma: A case report and review of literature. World J Clin Cases 2025; 13(21): 105066

"1. The order of the case report can be changed to bring clarity and understanding in the following manner. Chief complaints to be ..." [Read more]

"1. The order of the case report can be changed to bring clarity and understanding in the following manner. Chief complaints to be followed by other history (past, present, family), physical examination, laboratory findings, imaging in a sequence so that the reader can appreciate the methodical work up. 2. The conclusion can include the importance of imaging (MRI > US) in avoiding unnecessary surgery" [Collapse]

Ali S, Anjum A, Nasir KM, Khalid AR, Shahzad F, Nashwan AJ. Ovarian vein thrombosis mimicking acute appendicitis: A case report. World J Clin Cases 2025; 13(21): 103525

"1. The title does not indicate the study type. To include the type of article (descriptive review) 2. General principles of Gastro ..." [Read more]

"1. The title does not indicate the study type. To include the type of article (descriptive review) 2. General principles of Gastro Intestinal Stromal Tumor resection can be outlined (minimal handling, avoiding tumor rupture, maintaining surgical margins, etc) 3. The management can be summarised in a table/algorithm format 4. Inclusion of more figures can be helpful in better understanding" [Collapse]

Chen LQ, Wu CY, Wu SJ, Ye K. Laparoscopic surgical approaches for various locations of gastrointestinal stromal tumours. World J Clin Cases 2025; 13(21): 105559

"In this editorial, the authors emphasize the importance of Creeping Fat (CF) as a predictor indicating poor prognosis in Crohn's ..." [Read more]

"In this editorial, the authors emphasize the importance of Creeping Fat (CF) as a predictor indicating poor prognosis in Crohn's disease. The authors speculate that CF is associated with specific characteristics of small bowel Crohn's disease and present several reports to support this hypothesis. However, their description is more narrative than statistical. To strengthen their speculation, it would be better to include numerical data. Overall, while the editorial raises interesting points about CF, it would benefit from more quantitative evidence." [Collapse]

Wei H, Mai ZL, Ma BT, Chang B. Creeping fat: A promising radiological predictor in small bowel Crohn’s disease. World J Gastroenterol 2025; 31(16): 105186

"In addition to the discussion focusing on the morphalogy and volume of the pituitary neuroendocrine tumor in the editorial, the ..." [Read more]

"In addition to the discussion focusing on the morphalogy and volume of the pituitary neuroendocrine tumor in the editorial, the function status of a pituitary neuroendocrine tumor, target organs response, relevant homones, permissive action of hormone, and other factors should be addressed. Some tumors are large in size, but their functions are weak and secret less hormones, result in mild or moderate hazard; vice versa. " [Collapse]

Yang JS. Prognosis value of pituitary neuroendocrine tumor volume. World J Radiol 2025; 17(4): 106186

"Using four-dimensional flow magnetic resonance imaging technique for the evaluation of vascular flow hemodynamics is novel attempt. ..." [Read more]

"Using four-dimensional flow magnetic resonance imaging technique for the evaluation of vascular flow hemodynamics is novel attempt. The reviewer compliments this editorial for its rich content. Adverse the weaknesses of it are not neglected, as following: It’s a study of small sample, so it’s results and conclusion had better not be expressed as promising. The author commented on the study by Leesmidt et al should focus on the feasibility. Leesmidt et al said that superior and inferior mesenteric arteries were investigated and using Duplex ultrasound as a control.In fact, color Doppler ultrasound can measure the diameter and flow velocity of superior mesenteric artery reliable and conveniently, but it’s challenging to measure the diameter and flow velocity of inferior mesenteric artery. It’s hard to visualize the inferior mesenteric artery(vein). Measurement of the diameter and flow velocity of superior mesenteric vein is not so easy as that for the superior mesenteric artery. The author of this editorial did not raise inquiry of this. In this editorial, the author said“Duplex ultrasound is a non-radiative tool for obtaining vascular flow velocity information but has limitations in larger patients due to reduced acoustic windows and operator dependency.”. It should be specific, the evaluation of superior mesenteric artery is almost not handicapped by acoustic windows and operator dependency. It’s hard to follow that“The study provides valuable insights into the hemodynamics of abdominal vessels in children.”in this editorial. The “Conclusion”should focus on the additional role of four-dimensional flow magnetic resonance imaging for blood vessels and hemodynamics. Noteably, the reviewer checked the original article, and found that there is no involving of the inferior mesenteric artery(vein) in that article. " [Collapse]

Yang JS. Promising four-dimensional flow magnetic resonance imaging technique for vascular flow analysis in children. World J Radiol 2025; 17(4): 106185

"Strengths: A clinical issue orientation study, having practical significance. A better study design should avoid or reduce ..." [Read more]

"Strengths: A clinical issue orientation study, having practical significance. A better study design should avoid or reduce background confounder, e.g., to compare (NIC of tumor-NIC of normal tissue)/NIC of normal tissue and (NIC of lymph node-NIC ofof normal tissue)/NIC of normal tissue and obtain ratio. There was only TD+ and TD-, no golden reference. Expect the largest lmpha node, other size of lmpha nodes should be selected added to make the results more sound and rigorous." [Collapse]

"Compared with nondiabetic subjects, T2D patients had increased risks of cirrhosis of the liver, HCC, hepatic-related complications, ..." [Read more]

"Compared with nondiabetic subjects, T2D patients had increased risks of cirrhosis of the liver, HCC, hepatic-related complications, and mortality, irrespective of age or sex. Coexisting obesity, hypertension, and dyslipidemia worsened these risks, but regular exercise could ameliorate these outcomes. Diabetologists should be aware of the excessive risks of harmful hepatic outcomes in T2D patients, and a comprehensive medical evaluation with a meticulous assessment of the risks, improvement of associated metabolic dysfunctions, and enhancement of diabetes self-management education emphasizing the importance of regular physical activity are mandatory to reduce the hazards of hepatic-related diseases and mortality in T2D patients." [Collapse]

Chen HF, Chang YY, Chen P, Shen XH, Chang CH, Hsu WL. Risks of liver cirrhosis, hepatocellular carcinoma, hepatic-related complications, and mortality in patients with type 2 diabetes in Taiwan. World J Diabetes 2025; 16(5): 104576

"This study highlights the critical role of systemic inflammation, as reflected by SII, in the progression of early kidney damage in ..." [Read more]

"This study highlights the critical role of systemic inflammation, as reflected by SII, in the progression of early kidney damage in children with newly diagnosed T1DM. The findings underscore the potential of SII as a reliable and practical biomarker for identifying at-risk individuals. Future longitudinal research with extended follow-up and expanded biomarker panels will be essential to validate these findings and advance our understanding of diabetic nephropathy pathogenesis." [Collapse]

Cao LF, Xu QB, Yang L. Systemic immune indicators for predicting renal damage in newly diagnosed type 1 diabetic children. World J Diabetes 2025; 16(5): 104482

"The study advances the investigation of the safety of food supplements by exploring the effects of different doses of L-Arg on patients ..." [Read more]

"The study advances the investigation of the safety of food supplements by exploring the effects of different doses of L-Arg on patients with type 2 diabetes, thereby clarifying the complexity and limitations of L-Arg supplementation. L-Arg is the substrate of eNOS and can generate NO. As a key signaling molecule, NO plays roles in vasodilation, antioxidation, and anti-inflammation in the body. Additionally, NO can protect the heart from damage by inhibiting myocardial hypertrophy and fibrosis. However, when high doses of L-Arg are ingested, NO reacts with superoxide anions to form peroxynitrite, a strong oxidant that can cause cell damage, and the accumulation of superoxide anion exacerbates oxidative stress, leading to cardiomyocyte damage and cardiac dysfunction. Excess L-Arg may increase the production of ROS by activating pathways such as NADPH oxidase, which can attack lipids, proteins, and DNA, leading to cellular dysfunction and tissue damage. L-Arg can enhance cellular antioxidant capacity by activating the Nrf2 pathway, increasing the expression of antioxidant enzymes such as glutathione peroxidase and SOD, thereby exerting a protective effect on the heart, and high doses of L-Arg can lead to cardiomyocyte damage, fibrosis, and cardiac remodeling, further aggravating cardiac dysfunction . Over 0.5 g/kg L-Arg is not safe for daily administration. It may aggravate myocardial damage by increasing blood glucose levels, the oxidative stress response, inflammatory mediator levels, and cardiac remodeling. L-Arg supplementation has shown some potential in clinical and experimental studies, especially in areas such as cardiovascular health, immune regulation, and athletic performance improvement. However, the effects of L-Arg were found to be dose-dependent, with low doses exerting a protective effect by generating NO, while high doses may lead to tissue damage by increasing oxidative stress and inflammatory responses. However, there are still some issues to be addressed in future studies, including further optimization of human studies, accurate improvement of the maximum safe treatment dose for patients with type 2 diabetes, and further investigations of the frequency of daily intake of L-Arg in patients with type 2 diabetes and the effects of different doses of L-Arg on patients with type 1 diabetes." [Collapse]

Chen Y, Dai MT, Gong GH. L-arginine overdose is a potential risk factor for myocardial injury in patients with type 2 diabetes. World J Diabetes 2025; 16(5): 104409

"This study provides preliminary insights into the potential role of Nrf2 in the wound healing process of DFUs treated with NPWT. Our ..." [Read more]

"This study provides preliminary insights into the potential role of Nrf2 in the wound healing process of DFUs treated with NPWT. Our findings indicate that NPWT may enhance wound healing, possibly through the upregulation of Nrf2. This upregulation may activate antioxidant defense mechanisms, promote angiogenesis, and reduce inflammation, although further research is needed to confirm these effects." [Collapse]

Sun HJ, Si SW, Ma YM, Liu XK, Geng HF, Liang J. Role of nuclear factor erythroid 2-related factor 2 in negative pressure wound therapy for diabetic foot ulcers. World J Diabetes 2025; 16(5): 104350

"RCD of pancreatic β-cells plays a pivotal role in the onset and progression of DM, as the loss of functional β-cells leads to impaired ..." [Read more]

"RCD of pancreatic β-cells plays a pivotal role in the onset and progression of DM, as the loss of functional β-cells leads to impaired insulin secretion and disrupted glucose homeostasis. Targeting RCD of β-cells has therefore emerged as a promising therapeutic strategy for DM. PMS, a bioactive compound derived from TCM, is characterized by its versatility, safety and suitability for industrial synthesis, exhibiting diverse pharmacological properties through multiple pathways, such as inhibiting autophagy and apoptosis in different diseases. Although current research on the regulation of RCD such as ferroptosis, PANoptosis, and cuproptosis by PMS in DM is limited, the ongoing investigation is highly likely to uncover additional RCD pathways influenced by PMS. By specifically targeting the RCD of β-cells, PMS presents a potentially novel therapeutic strategy with a multitarget approach for improving DM management. However, there is still a lack of large-scale clinical trials assessing the effects of PMS in humans, and much of the existing preclinical data remains preliminary. While the molecular mechanisms discussed in the aforementioned research appear promising, the translation of PMS from bench to bedside remains a significant challenge, further investigation is warranted to comprehensively elucidate PMS pharmacological effects and evaluate its clinical applications." [Collapse]

Liu N, Yan WT, Xiong K. Plantamajoside: A potentially novel botanical agent for diabetes mellitus management. World J Diabetes 2025; 16(5): 104311

"Treatment of diabetic neuropathy is often limited by side effects. Aucubin, an iridoid glycoside derived from natural plants, exhibits ..." [Read more]

"Treatment of diabetic neuropathy is often limited by side effects. Aucubin, an iridoid glycoside derived from natural plants, exhibits notable anti-inflammatory and antioxidant properties. This study provides a crucial theoretical foundation for developing new therapeutic approaches for DNP. Aucubin mitigates the elevation of microglial aerobic glycolysis and inflammation in DNP via aldose reductase." [Collapse]

Zheng XZ, Yu HY, Chen YR, Fang JS. Aucubin mitigates the elevation of microglial aerobic glycolysis and inflammation in diabetic neuropathic pain via aldose reductase. World J Diabetes 2025; 16(5): 103915

"Interactions between the MTNR1B rs10830963 and CHEMERIN rs4721 SNPs play a significant role in the development of GDM, whereas SNPs ..." [Read more]

"Interactions between the MTNR1B rs10830963 and CHEMERIN rs4721 SNPs play a significant role in the development of GDM, whereas SNPs involved in folate metabolism do not show such a correlation. In addition, no significant gene-gene or gene-environment interactions involving the studied SNPs and GDM were identified. These findings are valuable for early screening and precise intervention for GDM in pregnant women, which could ultimately improve maternal and child health." [Collapse]

Zheng TT, Liu JH, Huang WT, Hong B, Wang D, Liu CY, Zhang J, Li SS, Wu SW, Wang Q, Chen L, Jin L. Single-nucleotide polymorphisms in genes involved in folate metabolism or selected other metabolites and risk for gestational diabetes mellitus. World J Diabetes 2025; 16(5): 103602

"The study confirmed the significant potential of SZF in ameliorating renal injury in DN mice. The primary pathway through which SZF ..." [Read more]

"The study confirmed the significant potential of SZF in ameliorating renal injury in DN mice. The primary pathway through which SZF mitigates renal injury appears to be the modulation of CYP450-mediated AA metabolism, which contributes to its anti-inflammatory and antioxidant effects (Figure 6). However, this investigation serves as a preliminary study on the effects and mechanisms of SZF. To comprehensively explore the mechanisms underlying SZF's treatment of DN, it must combine the findings with multiple validation methods, including in vitro experiments and single-cell RNA sequencing. This approach will provide reliable support for the clinical application of SZF." [Collapse]

Zhang ZY, Wang YM, Wang N, Wang YS, Zhang H, Wang D, Wang LX, Cui HT, Wen WB, Lv SQ, Cao YJ. Shenzhuo formulation ameliorates diabetic nephropathy by regulating cytochrome P450-mediated arachidonic acid metabolism. World J Diabetes 2025; 16(5): 103511

"The sample size of this study is relatively small, with only 78 cases included. Each surgery has specific indications and ..." [Read more]

"The sample size of this study is relatively small, with only 78 cases included. Each surgery has specific indications and contraindications, and compared to pharmacological treatments, fewer patients may be suitable for this procedure. This study primarily reviews the relevant indicators at 3 and 6 months post-surgery, which limits the ability to assess the long-term effects of the surgery on T2DM complications. Furthermore, the study did not adequately address the enhancement of patients' quality of life and their satisfaction with the subjective experience of treatment. Nonetheless, the study provides a valuable new perspective on the treatment of T2DM. Jejunoileal side-to-side anastomosis may offer new hope for patients with T2DM. Further in-depth and longer-term retrospective studies are needed to fully evaluate its long-term efficacy and impact." [Collapse]

Shao MQ, Liao JB, Zhai MY, Wan QQ, Jiang LJ, Cui HT. Jejunoileal side-to-side anastomosis: New hope for patients with type 2 diabetes? World J Diabetes 2025; 16(5): 103447

"This comprehensive analysis supports the potential association between prediabetes and the risk of CRC. These results highlight the ..." [Read more]

"This comprehensive analysis supports the potential association between prediabetes and the risk of CRC. These results highlight the significance of identifying and addressing hyperglycemia as early as possible to possibly prevent CRC and stress the necessity for customized prevention and screening approaches in individuals with prediabetes, although further interventional studies are needed for validation. Additional investigation is necessary to understand the underlying mechanisms of the association between prediabetes and the risk of CRC." [Collapse]

Wang N, Zhao TY, Ma X. Increased colorectal cancer risk in prediabetes: A meta-analysis. World J Diabetes 2025; 16(5): 103403

"The heterogeneity of DM is reflected in various aspects, including genetics, phenotype, and environmental factors. Integrating multiple ..." [Read more]

"The heterogeneity of DM is reflected in various aspects, including genetics, phenotype, and environmental factors. Integrating multiple types of data and conducting in-depth research on DM subtypes among different populations can greatly enhance our understanding of the complex pathogenesis of DM, and is helpful for predicting disease progression in individual patients. Moving forward, a large number of clinical trials with rigorous designs, sufficient sample size, and covering different populations are needed to verify the clinical significance of the various classification methods. Additionally, effective decision support tools based on the integration of multi-source data and advanced algorithms should be developed to analyse patient data in real time. These additional studies and tools will reshape medical standards for DM. By accurately classifying DM subtypes and providing customized medical services according to the characteristics of individual patients, we can effectively control blood glucose, reduce the occurrence of complications, lower medical costs, and provide patients with higher-quality, more efficient, and personalised medical services" [Collapse]

Jiang Q, Hu Y, Ma JH. Various classification methods for diabetes mellitus in the management of blood glucose control. World J Diabetes 2025; 16(5): 103316

"Beinaglutide is a novel GLP-1RA with a distinct structure (near 100% homology to human GLP-1) and pharmacokinetics compared to other ..." [Read more]

"Beinaglutide is a novel GLP-1RA with a distinct structure (near 100% homology to human GLP-1) and pharmacokinetics compared to other GLP-1RAs. The SRM revealed that beinaglutide use at 0.1-0.2 mg subcutaneously TID for 12-24 weeks was associated with modest benefits concerning body weight, BMI, and WC reduction, with no significant difference in glycemic and other metabolic end-points as compared to the control arm. Safety data was consistent with the other drugs in the GLP-1RA class, with a higher incidence of gastrointestinal adverse effects and treatment discontinuation due to AEs in the treatment arm, possibly due to the shorter half-life and multiple daily injections. The lack of longer duration trials, availability, and cost-effective analyses for beinaglutide vs other available GLP-1RAs limits its usability in the current scenario. However, the benefits concerning obesity/overweight outcomes, including measures of central adiposity, are encouraging despite the shorter half-life of the drug and duration of trials. Hence, longer-duration trials with multi-ethnic representation are needed to estimate the true potential of the molecule and find its place in the contemporary management of obesity and diabetes." [Collapse]

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