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Articles In Press
1
Kim JW, Park SY, Kim NI, Choi SK, Yoon JH. Mucocutaneous manifestation mimicking vasculitis in chronic hepatitis B: A case report. World J Clin Cases 2025; In press
2025-07-22 | Browse: 0 | Download: 0
2
Menia NK, Morya AK, Gupta PC, Ramachandran R. Ocular biomarkers in diabetes mellitus with diabetic kidney disease: A minireview. World J Nephrol 2025; In press
2025-07-22 | Browse: 0 | Download: 0
3
Maciel AT. Giving urine biochemistry a second chance in acute kidney injury monitor-ing. World J Crit Care Med 2025; In press
2025-07-22 | Browse: 0 | Download: 0
4
Yao MT, Wang T, Luo H, Yao MY, Chen K, Zhu YQ. Splenic histiocytic sarcoma: Disease progression from the perspective of pathophysiology. World J Clin Cases 2025; In press
2025-07-22 | Browse: 0 | Download: 0
5
Wang Q, Liu GG, Pan F, Xu JY, Jiao Y, Liu Q, Liu YH. Advances in the prevention and management of postoperative bleeding complications in pancreaticoduodenectomy: Current strategies and future directions precise. World J Clin Oncol 2025; In press
2025-07-22 | Browse: 0 | Download: 0
6
Sharma T, Kaushal N, Garla R. Toxins to treatments: Impact of environmental pollutants, gut microbiota, and natural compounds on non-alcoholic fatty liver disease progression. World J Hepatol 2025; In press
2025-07-22 | Browse: 1 | Download: 0
7
Gembillo G, Ricca MF, Santoro D. Diabetes-related renal complications: Insights on the impact of diabetic kidney disease on mortality. World J Nephrol 2025; In press
2025-07-22 | Browse: 0 | Download: 0
8
Galassi L, Ravini ML, Bassani R, Mercandalli G, Santoro GD. In the shadow of stability lies ruin: Occult vascular injuries in geriatric pelvic trauma. World J Clin Cases 2025; In press
2025-07-22 | Browse: 0 | Download: 0
9
Hu ZQ, Wang Y. Low salivary uric acid levels and periodontitis: New insights and implications for clinical practice. World J Clin Cases 2025; In press
2025-07-22 | Browse: 1 | Download: 0
10
Liu L, Xiao AQ, Cui XM, Jiang X, Zhou LD, Meng Q, Cai ZY, Ma Y, Liao RY. Integrating a traditional Chinese medicine hospice care system to address depression, anxiety, and sleep disorders in advanced cancer. World J Psychiatry 2025; In press
2025-07-21 | Browse: 0 | Download: 0
11
Zhao JJ, Han CY, Xu GX, Zhou M, Jin ZM. Effect of lurasidone plus sulpiride on treatment efficacy, psychiatric manifestations, and quality of life among patients with schizophrenia. World J Psychiatry 2025; In press
2025-07-21 | Browse: 0 | Download: 0
12
Li Z, Liu J, Lei W, Wang LB, Yang ZW. Anxiety and depression status in geriatric patients undergoing total hip arthroplasty: Correlation with postoperative pain and risk factors. World J Psychiatry 2025; In press
2025-07-21 | Browse: 1 | Download: 0
13
Fei LL, Zhao SX, Chen YF, Hao CF, Xin YJ. Exercise and sleep health in college students: Efficacy, mechanisms, and implications for practice. World J Psychiatry 2025; In press
2025-07-21 | Browse: 3 | Download: 0
14
Somanathan R, Gandhi S, Sivakumar T, Manjunatha N. Nurse-led treatment engagement interventions for persons with severe mental illnesses in community settings. World J Psychiatry 2025; In press
2025-07-21 | Browse: 0 | Download: 0
15
Byeon H. Tracing the hidden links between sadness, aggression, and peer victimization in adolescents. World J Psychiatry 2025; In press
2025-07-21 | Browse: 0 | Download: 0
16
Kim S, Kim N, Lee HS, Kim M, Kim H, Choi Y. Medical travel patterns for hepatocellular carcinoma treatment in South Korea: National Health Insurance data from 2013 to 2021. World J Gastrointest Oncol 2025; In press
2025-07-21 | Browse: 1 | Download: 0
17
Kirkik D, Ozabaci AN, Kalkanli Tas S. Changing patterns of cholangiocarcinoma and gallbladder cancer: A regional perspective from Northeastern Italy. World J Gastrointest Oncol 2025; In press
2025-07-21 | Browse: 10 | Download: 0
18
Zou YF, Zhang YG, Zhao ZC, Li Z, Liu HD, Li QY, Chen ZT, Zhu CJ, Liu HT, Wang JW, Li FY, Wang LJ, Zhang DC, Yang L, Xu H, Xu ZK, Wang S. Impact of non-alcoholic hepatic steatosis on prognosis and clinical outcomes in gastric cancer patients undergoing laparoscopic distal gastrectomy. World J Gastrointest Surg 2025; In press
2025-07-21 | Browse: 11 | Download: 0
19
Wang WQ, Yang JP, Dong JW, Chen YB. Misdiagnosis of Crohn’s disease as appendicitis: A case report. World J Gastrointest Surg 2025; In press
2025-07-21 | Browse: 12 | Download: 0
20
Yang MM, Tu W, Yan X. Effects of stellate ganglion block anesthesia on cognition and biomarkers in patients undergoing gastrointestinal surgery. World J Gastrointest Surg 2025; In press
2025-07-21 | Browse: 9 | Download: 0
709 items  Read more >>
Author Reviews
1
"This journal demonstrates outstanding efficiency with a rapid peer-review process typically completed within weeks, a well-structured ..."  [Read more]
"This journal demonstrates outstanding efficiency with a rapid peer-review process typically completed within weeks, a well-structured and transparent editorial workflow, and exceptionally fair and insightful reviewer feedback. Its expeditious publication timeline post-acceptance and clear, actionable editorial decisions significantly enhance the author experience. We are thoroughly satisfied with these streamlined operations and highly recommend this publication venue for its academic rigor and operational excellence. "  [Collapse]
He Q, Wu XH, Jiang DL, Lin RT, Xie F, Guan YH, Fei AH. Translocator protein facilitates neutrophil-mediated mucosal inflammation in inflammatory bowel diseases. World J Gastroenterol 2025; 31(27): 109239
2
"The review and publication work of the journal was done very well. The opinions given by the reviewers were very professional and ..."  [Read more]
"The review and publication work of the journal was done very well. The opinions given by the reviewers were very professional and useful. The quality of the article editing was very high. I am very satisfied with the publication process of this article. I am grateful to the publisher for recognizing my work and publishing my article "  [Collapse]
Li S, Zhu C, Tong L, Zheng XM, Rong C, Gao YK, Yuan DC, Wu XW. Correlation between radiomic features of Crohn's disease and secondary loss of response to infliximab. World J Gastroenterol 2025; 31(27): 109459
3
"Perfect editorial procedure. Expert reviewers with useful suggestion. Very good editorial system. Time schedule very efficient and ..."  [Read more]
"Perfect editorial procedure. Expert reviewers with useful suggestion. Very good editorial system. Time schedule very efficient and the status check on line is nice. The web page is quite easy to manage and each step is guided by editors. I recommend F6 publishing system to authors that are interested in high level pair reviewed paper pubblications . The format of the paper is nice and very easy to read. "  [Collapse]
Marino L, Bilotta F. Artificial intelligence in traumatic brain injury: Brain imaging analysis and outcome prediction: A mini review. World J Crit Care Med 2025; 14(3): 107611
4
"I am very much impressed with the comprehensive details of the publication process. Despite the vast amount of requirements, the ..."  [Read more]
"I am very much impressed with the comprehensive details of the publication process. Despite the vast amount of requirements, the automation and prompt in person responses makes the entire process smooth and fast. The quality of peer review is good and the time frame given for the response is apt. "  [Collapse]
Anegundi SS, Kurdi MS, Sutagatti JG, Theerth KA. Role of lung ultrasound in assessing positive end expiratory pressure induced lung recruitment in patients on mechanical ventilation. World J Crit Care Med 2025; 14(3): 102609
5
"I am impressed by the journal's high level of credibility. The editorial process was transparent and rigorous, and the reviewers were ..."  [Read more]
"I am impressed by the journal's high level of credibility. The editorial process was transparent and rigorous, and the reviewers were evidently experts in the field. Their insights and comments significantly enhanced the quality of our manuscript. The journal's commitment to maintaining rigorous standards is evident throughout the publication process. The peer review process was thorough, constructive, and highly beneficial. The reviewers provided detailed feedback that not only highlighted the strengths of our study but also pointed out areas for improvement. Their suggestions were well founded and practical, enabling us to refine our work and ensure its robustness. This rigorous peer review process is crucial for advancing scientific research and upholding the journal's reputation. Overall, I am extremely satisfied with the submission and review process of your journal. The communication was efficient and timely, and the requirements were clearly outlined. The entire experience was smooth and well - organized, from the initial submission to the final acceptance. I would highly recommend your journal to my colleagues and will definitely consider it for my future submissions. Thank you again for the opportunity to publish in your journal. I look forward to potential future collaborations and to contributing to the journal's continued success. "  [Collapse]
Zhao LM, Hong WY, Xu JG, Lin SQ, Liu MS, Wang LH, Jiang XL, Sang M, Lv YB. Nav1.6 drives colorectal cancer proliferation and invasion through MAPK signaling pathway. World J Gastrointest Oncol 2025; 17(7): 105264
6
"We are satisfied with the manuscript editing and publishing process. Thank you! We are satisfied with the online submission system. ..."  [Read more]
"We are satisfied with the manuscript editing and publishing process. Thank you! We are satisfied with the online submission system. The submission system is very user-friendly, with fast review speed and very useful reviewer feedback. The editor processes manuscripts very quickly, academically and professionally, making it a great magazine. We are very satisfied with the editing quality and review process of the manuscript. The reviewer's review comments are scientific, objective, and very useful for improving the quality of the manuscript. "  [Collapse]
Liao LG, Xiong ZG, Hu JJ. Progress in the treatment of duodenal cancer: A comprehensive review. World J Gastrointest Oncol 2025; 17(7): 105712
7
"My overall experience with publishing my manuscript with F6Publishing was exceptional. The submission process was smooth, the peer ..."  [Read more]
"My overall experience with publishing my manuscript with F6Publishing was exceptional. The submission process was smooth, the peer review edits were helpful, and the journal staff were always available for communication. All of the publication requirements made sense and were explained well. Thank you for making it such a good experience. "  [Collapse]
Harris JT, Gurley S, Borazanci E. Adult pancreatoblastoma: Systematic review of the literature and case report of a young adult patient. World J Gastrointest Oncol 2025; 17(7): 106701
8
"We are extremely satisfied with every aspect of the publication process. The promptness of the decision-making was particularly ..."  [Read more]
"We are extremely satisfied with every aspect of the publication process. The promptness of the decision-making was particularly noteworthy, and the editors provided invaluable, pertinent, and consistently respectful comments that led to significant improvements in our manuscript. This highly efficient editorial process greatly facilitated the timely and successful dissemination of our work. "  [Collapse]
Alvarez M, Prieto AE, Portilla N, Moya D, Rincon O, Guzman I. Metformin-induced vitamin B12 deficiency: An underdiagnosed cause of diabetic neuropathy. World J Diabetes 2025; 16(7): 107514
9
"Overall, my experience with the publication process was very positive. The communication from the editorial team was clear and timely, ..."  [Read more]
"Overall, my experience with the publication process was very positive. The communication from the editorial team was clear and timely, and I felt supported at every stage of the process. I appreciate the professionalism displayed throughout. I look forward to submitting future manuscripts to this journal and will gladly recommend it to my colleagues. "  [Collapse]
Zhi ZZ, Liu T, Kang J, Zhou FC, Liu XD, He ZM. miR-365 promotes HOXA9-mediated differentiation of mesenchymal stem cells to nucleus pulposus cells by interacting with HIF-1α. World J Orthop 2025; 16(7): 107045
10
"I found the entire submission process exceptionally efficient and user-friendly. The editorial team managed timelines effectively. ..."  [Read more]
"I found the entire submission process exceptionally efficient and user-friendly. The editorial team managed timelines effectively. Most notably, the reviewers provided remarkably prompt, insightful, and constructive critiques. Their expertise was evident, and their specific suggestions contributed significantly to enhancing the manuscript's quality. This reflects a highly professional operation from start to finish. "  [Collapse]
Sun RM, Dai DX, Xu F, Ling YL, Xie ZJ. Factors influencing insulin requirements in using continuous subcutaneous insulin infusion or multiple daily injections in type 2 diabetes. World J Diabetes 2025; 16(7): 106470
11
"Reviewing and editing were superb, the paper looks realluy great. Thanks for the editors and reviewers for their work into improving ..."  [Read more]
"Reviewing and editing were superb, the paper looks realluy great. Thanks for the editors and reviewers for their work into improving our paper. We are really satisfied. It is alwas a pleasure to work with BPG - the publishing process is streamlined and easy to follow. The papers are very well edited. Thank you for the hard work. "  [Collapse]
Hussain S, Soldera J. Telemedicine in cardiac arrest protocols: Comparative impact of video and audio dispatcher assistance. World J Crit Care Med 2025; 14(3): 103402
12
"It was difficult for the editor to find reviewers with knowledge in the nutritional epigenetics line of research. I was impressed ..."  [Read more]
"It was difficult for the editor to find reviewers with knowledge in the nutritional epigenetics line of research. I was impressed with the fortitude and perseverance demonstrated by the editor. Eventually, the reviewers were found and the objectives were met. The reviews were thorough and very professional. I highly recommend the WJEM for other researchers wishing to publish their articles on the topic of experimental medicine. "  [Collapse]
Dufault RJ. Biomarkers for tracking metabolic changes pre-post nutritional epigenetics diet/intervention to prevent autism and attention deficit/hyperactivity disorders in children. World J Exp Med 2025; 15(2): 101555
13
"The submission process is professional and efficient, with a rigorous approach and a user-friendly submission interface that is ..."  [Read more]
"The submission process is professional and efficient, with a rigorous approach and a user-friendly submission interface that is tailored to the needs of authors. The only drawback is that the checklist before submission is somewhat complex, requiring a considerable amount of time to fully understand. Nevertheless, the overall submission process is very pleasant. "  [Collapse]
Zhu YF, Zhang DW, Zhang M, Yu MH, Zhang SH, Wu YY. Prognostic value of immune-inflammation and nutritional indices in advanced hepatocellular carcinoma patients receiving immunotherapy with compound Kushen injection. World J Gastrointest Oncol 2025; 17(7): 106684
14
"As always, Baishideng Publishing Group (BPG) provides the best publishing ever. The Reference Citation Analysis (RCA) tools it the ..."  [Read more]
"As always, Baishideng Publishing Group (BPG) provides the best publishing ever. The Reference Citation Analysis (RCA) tools it the best ever experienced across all publishing houses. The transparency of the peer review process and the constructive peer review feedback makes the entire publishing experience a memorable one. The published format is the best across all formats. "  [Collapse]
Swain A, Nag DS, Laik JK, Sahu S, Panchal M, Srirala S. Unplanned intensive care unit admissions in trauma patients: A critical appraisal. World J Crit Care Med 2025; 14(3): 105147
15
"it is better to give the evaluation in score from 1-5 including (not applicable). Otherwise, it was a great experience to publish ..."  [Read more]
"it is better to give the evaluation in score from 1-5 including (not applicable). Otherwise, it was a great experience to publish in the WJCCM. The reviewers response was fair and the time to publish was to someextent fair. The topic was relevant to the journal thems and was produced in a nice way. Thanks "  [Collapse]
Al-Thani H, El-Menyar A, Mekkodathil A, Taha I, Mahmood S, Shunni A, Hammo AA, Al-Ani M, Asim M. Significance of a hypotensive episode following traumatic injury: A retrospective observational study. World J Crit Care Med 2025; 14(3): 104778
16
"Publishing with BPG consistently proves to be a rewarding and engaging process. The journals reach a broad, international readership, ..."  [Read more]
"Publishing with BPG consistently proves to be a rewarding and engaging process. The journals reach a broad, international readership, ensuring that your research is seen by many in the field. Articles are frequently cited, enhancing the visibility and impact of your work, while the editorial team is professional, responsive, and supportive throughout the submission process. "  [Collapse]
Milionis C, Zoumakis E, Tselebis A, Ilias I. Endocrine issues in critically ill transgender patients: A narrative review. World J Crit Care Med 2025; 14(3): 100660
17
"Publishing with BPG is always an interesting and rewarding experience. The journals are well-read and easily accessible to a wide ..."  [Read more]
"Publishing with BPG is always an interesting and rewarding experience. The journals are well-read and easily accessible to a wide international audience, which helps your work gain visibility in the field. Their articles get cited often, increasing the impact of your research, and the editorial process is usually efficient and supportive. "  [Collapse]
Savvidis C, Ragia D, Kallistrou E, Kouroglou E, Tsiama V, Proikaki S, Belis K, Ilias I. Critical illness-implications of non-thyroidal illness syndrome and thyroxine therapy. World J Crit Care Med 2025; 14(3): 102577
18
"Thanks for the excellent publication services provided by the World Journal of Gastrointestinal Oncology, including the professional, ..."  [Read more]
"Thanks for the excellent publication services provided by the World Journal of Gastrointestinal Oncology, including the professional, impartial, and transparent peer review and editing processes. I am very pleased to share the successful treatment combination for advanced cholangiocarcinoma, a challenging disease. I believe this will inspire more peers in the field to explore further, contributing to the advancement of research and clinical practice in this area. "  [Collapse]
Xie JP, Tang YJ, Fan YW, Huang YZ, Deng M, Zhang TZ, Li Y, Deng G, Tang D. Pathological complete response in advanced intrahepatic cholangiocarcinoma was achieved through tri-modal therapy: A case report and review of literature. World J Gastrointest Oncol 2025; 17(7): 108650
19
"This journal maintains high credibility through its stringent peer review, efficient editorial handling, and adherence to ethical ..."  [Read more]
"This journal maintains high credibility through its stringent peer review, efficient editorial handling, and adherence to ethical guidelines. I am satisfied with the manuscript editing and publishing process.I am satisfied with all aspects of the review process.The reviewers and editors are very serious and responsible, and they strictly control each review step.I hope to publish more articles in the future in the World Journal of Diabetes. "  [Collapse]
Li YF, Wei Y, Li MR, Sun ZZ, Xie WY, Li QF, Xie CH, Xiang JY, Tan X, Qiu SJ, Liang Y. Detect the disrupted brain structural connectivity in type 2 diabetes mellitus patients without cognitive impairment. World J Diabetes 2025; 16(7): 103468
20
"First of all, we truly appreciate the opportunity to publish our case report in World Journal of Gastrointestinal Oncology. The peer ..."  [Read more]
"First of all, we truly appreciate the opportunity to publish our case report in World Journal of Gastrointestinal Oncology. The peer reviews provided invaluable guidance that helped us refine the case presentation, making it more specific, detailed, and well-structured. In particular, the suggestion to include a diagnostic timeline was eye-opening for us, as it was something we had not considered initially. Once we implemented it, the diagnostic process became significantly clearer and more accessible to readers. Additionally, the recommendation to elaborate on the biopsy details—given the oncology focus of the journal—prompted extensive discussion with our pathologist, leading to the inclusion of more representative histological images. We fully agree that this addition enhances readers’ understanding of the typical patterns seen in esophageal squamous cell carcinoma. Lastly, we are sincerely grateful for the insightful and constructive feedback from the reviewer team, and for the professional support from the publisher. Their efforts truly elevated the quality of our submission and allowed it to be presented in its best form. "  [Collapse]
He YS, Lee CY, Shieh TY. Pseudoachalasia as first manifestation of a diffusely infiltrative esophageal squamous cell carcinoma: A case report. World J Gastrointest Oncol 2025; 17(7): 108162
19064 items  Read more >>
Article Quality Tracking-Peer-Review
1
"Kwon et al. reported that deep learning-based localization and lesion detection in capsule endoscopy for patients with suspected ..."  [Read more]
"Kwon et al. reported that deep learning-based localization and lesion detection in capsule endoscopy for patients with suspected small-bowel bleeding. It maybe true the AI-based localization and lesion detection is very useful for the discovery of small-bowel bleeding in patients. If possible, authors should distribute these application for everyone examine their figures. If so, everyone could recognize the results of authors."  [Collapse]
Kwon YS, Park TY, Kim SE, Park Y, Lee JG, Lee SP, Kim KO, Jang HJ, Yang YJ, Cho BJ. Deep learning-based localization and lesion detection in capsule endoscopy for patients with suspected small-bowel bleeding. World J Gastroenterol 2025; 31(27): 106819
2
"Excellently presented study. All points are very well taken. The article provides a comprehensive perspective on all contemporary ..."  [Read more]
"Excellently presented study. All points are very well taken. The article provides a comprehensive perspective on all contemporary aspects of variceal hemorrhage management. The article is written so that it is recommended for gastroenterologists, general surgeons, hospitalists, and emergency medicine physicians. The Authors' effort constitutes a major contribution towards updating the current knowledge and understanding of the problem, and provides a foundation for database perfection. "  [Collapse]
Kogilathota Jagirdhar GS, Okafor CC, Hussain M, Elmati PR, Ghumman A, Shah M, Surani S. Decline of the Sengstaken-Blakemore tube: A review of shifting practices in gastrointestinal hemorrhage management. World J Crit Care Med 2025; 14(3): 101856
3
"Only three articles examined are very few, the search should be expanded. also missing the PROSPERO membership number and the PRISMA ..."  [Read more]
"Only three articles examined are very few, the search should be expanded. also missing the PROSPERO membership number and the PRISMA check-list. More detailed information on research should be provided to make it more rigorous. It would also be useful to specify the limitations of the study and what can be done in future studies to improve these limits Finally , a English editing is needed."  [Collapse]
Yousif Mohamed AM, Salih M, Mohamed M, Abbas AE, Elsiddig M, Osama Omar M, Abdelsalam M, Elhag B, Mohamed N, Eisa Ahmed SH, Ahmed S, Mohamed D, Omar D. Comparative efficacy of cementless bipolar hemiarthroplasty and proximal femoral nail anti-rotation in unstable intertrochanteric fractures: A meta-analysis. World J Orthop 2025; 16(7): 107950
4
"Survival rates following radical surgery for gastric neuroendocrine neoplasms (g-NENs) are low, with high recurrence rates. Liu, et ..."  [Read more]
"Survival rates following radical surgery for gastric neuroendocrine neoplasms (g-NENs) are low, with high recurrence rates. Liu, et al’s study addressed a critical issue in determining the postoperative prognosis of gastric neuroendocrine tumors by identifying the significance of lymph node ratio. Moreover, the random survival forest model, a machine-learning approach, surpasses traditional Cox proportional hazards models by enhancing predictive accuracy, clinical utility, and overall performance. This model’s ability to stratify patient risks and personalize survival predictions can aid in formulating targeted postoperative strategies, thus realizing an important aspect of personalized “precision medicine”. This paper is indicative for journal readers in this field."  [Collapse]
Wang HN, An JH, Zong L. Estimating prognosis of gastric neuroendocrine neoplasms using machine learning: A step towards precision medicine. World J Gastrointest Oncol 2024; 16(12): 4548-4552
5
"Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths due to late diagnosis and high recurrence rates. ..."  [Read more]
"Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths due to late diagnosis and high recurrence rates. Key biomarkers such as enhancer of zeste homolog 2 and fatty acid binding protein 5, along with other genetic biomarkers provide insights into HCC progression and potential therapeutic targets. This paper is indicative for journal readers in this field. "  [Collapse]
Shodry S, Hasan YTN, Ahdi IR, Ulhaq ZS. Gene targets with therapeutic potential in hepatocellular carcinoma. World J Gastrointest Oncol 2024; 16(12): 4543-4547
6
"In this Editorial we comment on the interesting article by Liu, et al. The controlling nutritional status (CONUT) score was ..."  [Read more]
"In this Editorial we comment on the interesting article by Liu, et al. The controlling nutritional status (CONUT) score was significantly associated with the prognosis of colorectal cancer patients, as supported by a large body of literature. Compared with other nutritional scores, the CONUT score might be introduced in clinical practice as an optimal prognostic nutritional index to predict patient outcome."  [Collapse]
Berardi R, Chiariotti R, Mentrasti G. Is nutritional status a new indicator to use in clinical practice for colorectal cancer patients? World J Gastrointest Oncol 2024; 16(12): 4537-4542
7
"In this Editorial, they highlighted potential pitfalls in the current classification of mixed neuroendocrine non-neuroendocrine ..."  [Read more]
"In this Editorial, they highlighted potential pitfalls in the current classification of mixed neuroendocrine non-neuroendocrine neoplasms and commented on challenges in the management of this heterogeneous group of malignancies in light of the paucity of evidence in the field. Improved biological and clinical knowledge were needed to generate robust classification schemes that will in turn provide clarity on the epidemiology of the disease, prognosis of affected patients and guidance for treatment tailoring. This paper is indicative for journal readers in this field."  [Collapse]
Cives M, Porta C, Palmirotta R. Mixed neuroendocrine non-neuroendocrine tumors: The quest for evidence. World J Gastrointest Oncol 2024; 16(12): 4532-4536
8
"Gastric cancer remains a formidable global health concern with significant morbidity and mortality rates, despite the fact that ..."  [Read more]
"Gastric cancer remains a formidable global health concern with significant morbidity and mortality rates, despite the fact that numerous advances have been made to improve conventional therapies. This Editorial article integrated network pharmacology insights with rigorous experimental validation to highlight the potential of Xiaojianzhong decoction as a multifaceted therapeutic approach for gastric cancer. This paper is indicative for journal readers in this field."  [Collapse]
Cheng CH, Hao WR, Cheng TH. Exploring Xiaojianzhong decoction's potential in gastric cancer treatment: Integrative insights and experimental validation. World J Gastrointest Oncol 2024; 16(12): 4553-4558
9
"Mixed neuroendocrine non-neuroendocrine neoplasms constitute rare tumors that are located mainly in the gastrointestinal tract and ..."  [Read more]
"Mixed neuroendocrine non-neuroendocrine neoplasms constitute rare tumors that are located mainly in the gastrointestinal tract and have high degrees of malignancy, and the frequency of these tumors has been increasing. The rare but steadily increasing number of gastrointestinal mixed neuroendocrine non-neuroendocrine neoplasms and pure neuroendocrine carcinomas require more radical treatment than slow-growing neuroendocrine neoplasms do and they are related to poor prognosis. They constitute a complicated diagnostic and therapeutic challenge. The current management strategy begins with surgery and is followed by chemotherapy. New chemotherapeutics and novel biological agents for targeted therapy, along with immunotherapy broaden the range of therapeutic options, providing promising outcomes. Effective management should be individualized and multidisciplinary. This paper is indicative for journal readers in this field."  [Collapse]
Pavlidis ET, Galanis IN, Pavlidis TE. Critical considerations for the management of gastrointestinal mixed neuroendocrine non-neuroendocrine neoplasms and pure neuroendocrine carcinomas. World J Gastrointest Oncol 2024; 16(12): 4559-4564
10
"Within the intricate milieu of colorectal cancer (CRC) tissues, cancer-associated fibroblasts (CAFs) act as pivotal orchestrators, ..."  [Read more]
"Within the intricate milieu of colorectal cancer (CRC) tissues, cancer-associated fibroblasts (CAFs) act as pivotal orchestrators, wielding considerable influence over tumor progression. Their review endeavored to dissect the multifaceted functions of CAFs within the realm of CRC, thereby highlighting their indispensability in fostering CRC malignant microenvironment and indicating the development of CAFs-targeted therapeutic interventions. Through a comprehensive synthesis of current knowledge, their review delineated insights into CAFs-mediated modulation of cancer cell proliferation, invasiveness, immune evasion, and neovascularization, elucidating the intricate web of interactions that sustain the pro-tumor metabolism and secretion of multiple factors. Additionally, recognizing the high level of heterogeneity within CAFs is crucial, as they encompass a range of subtypes, including myofibroblastic CAFs, inflammatory CAFs, antigen-presenting CAFs, and vessel-associated CAFs. Innovatively, the symbiotic relationship between CAFs and the intestinal microbiota is explored, shedding light on a novel dimension of CRC pathogenesis. Despite remarkable progress, the orchestrated dynamic functions of CAFs remain incompletely deciphered, underscoring the need for continued research endeavors for therapeutic advancements in CRC management. This review article is well written, and is informative for journal readers in this field."  [Collapse]
Cui JY, Ma J, Gao XX, Sheng ZM, Pan ZX, Shi LH, Zhang BG. Unraveling the role of cancer-associated fibroblasts in colorectal cancer. World J Gastrointest Oncol 2024; 16(12): 4565-4578
11
"In their report, they assessed the prognostic value of gamma-glutamyl transpeptidase to platelet ratio (GPR) in early hepatitis B ..."  [Read more]
"In their report, they assessed the prognostic value of gamma-glutamyl transpeptidase to platelet ratio (GPR) in early hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients. They evaluated the clinical utility of preoperative GPR in predicting outcomes for solitary HBV-related HCC patients using propensity score matching, restricted cubic spline, survival analyses and stratified analyses. Preoperative GPR levels facilitated recurrence monitoring and inform treatment strategies, potentially enhancing the quality of life for HCC patients. Although case report accompanied with some limitations for any conclusions, their report is interesting for journal readers in this field."  [Collapse]
Yang CK, Wei ZL, Shen XQ, Jia YX, Wu QY, Wei YG, Su H, Qin W, Liao XW, Zhu GZ, Peng T. Prognostic utility of gamma-glutamyl transpeptidase to platelet ratio in patients with solitary hepatitis B virus-related hepatocellular carcinoma after hepatectomy. World J Gastrointest Oncol 2024; 16(12): 4579-4596
12
"Their developed and validated a promising machine learning architecture for predicting the 3-category survival times (cutoff values ..."  [Read more]
"Their developed and validated a promising machine learning architecture for predicting the 3-category survival times (cutoff values of 3 years and 5 years) for four survival times (overall, disease-free, recurrence-free, and distant metastasis-free survival) and screened corresponding important variables. Fivefold cross validation and bootstrap validation were conducted. The models were evaluated with the area under the curve (AUC); moreover, the effectiveness of our variable screening methods was evaluated by comparing the models’ pre- and post-screening AUCs. SHapley Additive exPlanations were used to explain the decision-making process. Nomograms were drawn for various applications. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field."  [Collapse]
Ji XL, Xu S, Li XY, Xu JH, Han RS, Guo YJ, Duan LP, Tian ZB. Prognostic prediction models for postoperative patients with stage I to III colorectal cancer based on machine learning. World J Gastrointest Oncol 2024; 16(12): 4597-4613
13
"Their retrospective study explores the safety, efficacy, and long-term prognosis of local excision (LE) in patients with middle-low ..."  [Read more]
"Their retrospective study explores the safety, efficacy, and long-term prognosis of local excision (LE) in patients with middle-low rectal cancer who responded well to neoadjuvant chemoradiotherapy. Their results demonstrated that LE can achieve high rates of organ preservation and favorable oncological outcomes, including a 5-year disease-free survival rate of 88.4% and overall survival rate of 92.9%. Complications were manageable and non-severe. Their study supported the potential of minimally invasive treatments in selected patients, highlighting the importance of patient participation in treatment decisions. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field."  [Collapse]
Chen N, Li CL, Wang L, Yao YF, Peng YF, Zhan TC, Zhao J, Wu AW. Local excision for middle-low rectal cancer after neoadjuvant chemoradiation: A retrospective study from a single tertiary center. World J Gastrointest Oncol 2024; 16(12): 4614-4624
14
"Their retrospective analyses spanned a decade (January 1, 2012 to September 30, 2022) and included 5417 patients from Beijing Youan ..."  [Read more]
"Their retrospective analyses spanned a decade (January 1, 2012 to September 30, 2022) and included 5417 patients from Beijing Youan Hospital, Capital Medical University. Using Cox regression and competing risk regression models, they identified several key factors that significantly contributed to the risk of hepatocellular carcinoma in patients with cirrhosis. Specifically, their study underscored the increased association of hepatitis B cirrhosis with hepatocellular carcinoma incidence and highlights other significant risk factors, including male sex, advanced age, viral hepatitis-related cirrhosis, elevated blood ammonia, and lower albumin and platelet levels. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field."  [Collapse]
Zhou DQ, Liu JY, Zhao F, Zhang J, Liu LL, Jia JR, Cao ZH. Risk factors for hepatocellular carcinoma in cirrhosis: A comprehensive analysis from a decade-long study. World J Gastrointest Oncol 2024; 16(12): 4625-4635
15
"The Esophageal cancer (EC) often occurs in the elderly, with approximately 33% of patients aged ≥ 75 years at the time of diagnosis. ..."  [Read more]
"The Esophageal cancer (EC) often occurs in the elderly, with approximately 33% of patients aged ≥ 75 years at the time of diagnosis. Since patients aged 75 years and above are often excluded from many clinical trials of EC, there is a lack of agreement regarding the prognosis and treatment of this population. They retrospectively analyzed the clinical characteristics, toxic reactions, and survival information of elderly patients with EC aged ≥ 75 years who received intensity-modulated radiotherapy. Their analyses aimed to evaluate the prognostic factors affecting overall survival. They found that the Charlson comorbidity index and nutritional risk screening 2002 were independent prognostic factors for overall survival. Their results suggested that when formulating treatment plans for elderly patients with EC, full attention should be given to age-related biological indicators such as comorbidities and nutrition. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field."  [Collapse]
Hu LL, Rong F, Liu L, Zhang L, Zhang LL, Yang Q, Xia ZL, Wang H. Prognosis of radiotherapy for esophageal cancer in elderly patients exceeding seventy-five years old. World J Gastrointest Oncol 2024; 16(12): 4636-4649
16
"The γ-glutamyl transferase to albumin ratio has been confirmed for the first time to be predictive in hepatocellular carcinoma ..."  [Read more]
"The γ-glutamyl transferase to albumin ratio has been confirmed for the first time to be predictive in hepatocellular carcinoma undergoing transarterial chemoembolization and transarterial chemoembolization combined with systemic therapy in this large-sample multicenter study. A nomogram model for predicting postoperative survival was also established based on γ-glutamyl transferase to albumin ratio, which was empirically demonstrated to have strong predictive ability. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field."  [Collapse]
Wu ZY, Li H, Chen JL, Su K, Weng ML, Han YW. Nomogram model based on γ-glutamyl transferase to albumin ratio predicts survival in hepatocellular carcinoma patients with transarterial chemoembolization treatment. World J Gastrointest Oncol 2024; 16(12): 4650-4662
17
"The deep learning model (DLM) was validated to accurately predict the risk classification of gastrointestinal stromal tumors. The ..."  [Read more]
"The deep learning model (DLM) was validated to accurately predict the risk classification of gastrointestinal stromal tumors. The combined DLM outperformed DLM in predicting risk stratification. The combined model has potential to guide and facilitate clinical decision-making. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field."  [Collapse]
Li Y, Liu YB, Li XB, Cui XN, Meng DH, Yuan CC, Ye ZX. Deep learning model combined with computed tomography features to preoperatively predicting the risk stratification of gastrointestinal stromal tumors. World J Gastrointest Oncol 2024; 16(12): 4663-4674
18
"In their study, patients diagnosed with advanced gastroenteropancreatic neuroendocrine tumors who were treated with the temozolomide ..."  [Read more]
"In their study, patients diagnosed with advanced gastroenteropancreatic neuroendocrine tumors who were treated with the temozolomide and capecitabine regimen exhibited a median overall survival of 49 months, with 42% surviving at 60 months. The regimen was well-tolerated, and most patients experienced stable disease. Their results suggested that this treatment could be viable in settings where standard therapies are unavailable or inaccessible, although further prospective studies were needed for confirmation. Although their study design accompanied with some limitations for any conclusions, their results were informative for journal readers in this field."  [Collapse]
Cruz-Diaz WE, Paitan V, Medina J, Flores R, Haro-Varas J, Mantilla R, Castro-Oliden V. Temozolomide and capecitabine regimen as first-line treatment in advanced gastroenteropancreatic neuroendocrine tumors at a Latin American reference center. World J Gastrointest Oncol 2024; 16(12): 4675-4684
19
"Supplementation with 1,25-dihydroxy-vitamin D [1,25(OH)2D3] improved hepatic steatosis and lipid metabolism in nonalcoholic fatty ..."  [Read more]
"Supplementation with 1,25-dihydroxy-vitamin D [1,25(OH)2D3] improved hepatic steatosis and lipid metabolism in nonalcoholic fatty liver disease, linked to its capacity to reverse the proinflammatory M1 polarization of hepatic macrophages, partially by regulating the vitamin D receptor-peroxisome proliferator activated receptor γ pathway. The involvement of 1,25(OH)2D3 in inhibiting fatty-acid-induced proinflammatory M1 polarization of macrophages played a direct role in relieving lipid accumulation and metabolism in hepatocytes. Their results are informative for journal readers in this field."  [Collapse]
Luo WJ, Dong XW, Ye H, Zhao QS, Zhang QB, Guo WY, Liu HW, Xu F. Vitamin D 1,25-Dihydroxyvitamin D3 reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization. World J Gastrointest Oncol 2024; 16(12): 4685-4699
20
"Despite advances in therapy for colorectal cancer (CRC), the 5-year survival rate for CRC patients in China remains only 56.9%. Their ..."  [Read more]
"Despite advances in therapy for colorectal cancer (CRC), the 5-year survival rate for CRC patients in China remains only 56.9%. Their study explored the effects of matrine on CRC by targeting a newly identified anti-apoptotic protein, Shank-associated RH domain interactor (SHARPIN). SHARPIN was discovered through proteomic analysis and its expression was validated in both the TCGA database and our patient cohort using immunohistochemistry. Inhibiting SHARPIN expression led to increased apoptosis and reduced proliferation, invasion, and migration of CRC cells in vitro. Matrine's ability to inhibit SHARPIN and induce apoptosis highlights its potential as a promising therapeutic agent for CRC. Their results are informative for journal readers in this field."  [Collapse]
Zhou YC, Wang QQ, Zhou GYJ, Yin TF, Zhao DY, Sun XZ, Tan C, Zhou L, Yao SK. Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression. World J Gastrointest Oncol 2024; 16(12): 4700-4715
15689 items  Read more >>
Peer-Reviewers and Manuscript Statistics
Editorial board members
2265
Peer-reviewers
32442
Manuscripts received today
2
Manuscript reviews today
10
Unhandled manuscripts today
144
Active peer-reviewers today
535
Reviewer acceptance today
15
Reviewer refusals today
15
Total accepted manuscripts
36935
Total rejected manuscripts
42417
Total peer-reviewers
4293784
Total submissions
35049
Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.
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All Journal Articles
1

Parchwani D, Singh R, Patel D. Biological and translational attributes of mitochondrial DNA copy number: Laboratory perspective to clinical relevance. World J Methodol 2025; 15(3): 102709

2025-09-20 | Browse: 5038 | Download: 799
2

Tawheed A, Ismail A, El-Tawansy A, Maurice K, Ali A, El-Fouly A, Madkour A. Third space endoscopy pulmonary complications and chylothorax post peroral endoscopic myotomy. World J Methodol 2025; 15(3): 102703

2025-09-20 | Browse: 4803 | Download: 783
3

Bajpai J, Saxena M, Pradhan A, Kant S. Sotatercept: A novel therapeutic approach for pulmonary arterial hypertension through transforming growth factor-β signaling modulation. World J Methodol 2025; 15(3): 102688

2025-09-20 | Browse: 5808 | Download: 747
4

Bale BI, Zeppieri M, Idogen OS, Okechukwu CI, Ojo OE, Femi DA, Lawal AA, Adedeji SJ, Manikavasagar P, Akingbola A, Aborode AT, Musa M. Seeing the unseen: The low treatment rate of eye emergency in Africa. World J Methodol 2025; 15(3): 102477

2025-09-20 | Browse: 5654 | Download: 847
5

Vo LT, Vu T, Pham TN, Trinh TH, Nguyen TT. Machine learning-based models for prediction of in-hospital mortality in patients with dengue shock syndrome. World J Methodol 2025; 15(3): 101837

2025-09-20 | Browse: 5100 | Download: 1090
6

Chauhan R, Padiyar N, Kaurani P, Gupta A, Chauhan S. Comparative evaluation of retentive capacity of three different attachment systems for implant retained overdentures: An in vitro study. World J Methodol 2025; 15(3): 101057

2025-09-20 | Browse: 5308 | Download: 944
7

Shah P, Shah VM, Saravanan VR, Kumar K, Narendran S. Evaluation of macular and peripapillary structure and microvasculature with optical coherence tomography angiography in migraine in Indian population. World J Methodol 2025; 15(3): 100950

2025-09-20 | Browse: 4927 | Download: 1039
8

Drăgoi AL, Nemeș RM. “Electronic Pediatrician”, a non-machine learning prototype artificial intelligence software for pediatric computer-assisted pathophysiologic diagnosis — general presentation. World J Methodol 2025; 15(3): 100903

2025-09-20 | Browse: 4970 | Download: 1010
9

Drăgoi AL, Nemeș RM. The remarkable effects of the ionized medical water Asea® in 3 boys with Duchenne dystrophy: Three case reports. World J Methodol 2025; 15(3): 100840

2025-09-20 | Browse: 6312 | Download: 904
10

Fawaz P, El Sayegh P, Vande Vannet B. Artificial intelligence in revolutionizing orthodontic practice. World J Methodol 2025; 15(3): 100598

2025-09-20 | Browse: 8121 | Download: 956
11

Khokhar RK, Nashwan AJ. Gut virome and its emerging role in inflammatory bowel disease. World J Methodol 2025; 15(3): 100534

2025-09-20 | Browse: 3541 | Download: 735
12

English K. Echo contrast medium: How the use of contrast echocardiography (ultrasound contrast agents) can improve patient care. World J Methodol 2025; 15(3): 100490

2025-09-20 | Browse: 4514 | Download: 748
13

Tramontana A, Rulli M, Falegnami A, Bilotta F. Visual avatar to increase situational awareness in anaesthesia: Systematic review of recent evidence. World J Methodol 2025; 15(3): 100459

2025-09-20 | Browse: 4855 | Download: 802
14

Li XL, Megdadi M, Quadri HS. Interaction between gut virome and microbiota on inflammatory bowel disease. World J Methodol 2025; 15(3): 100332

2025-09-20 | Browse: 3564 | Download: 664
15

Raveendran AV. Clinical inertia in sexual medicine practice. World J Methodol 2025; 15(3): 99874

2025-09-20 | Browse: 4728 | Download: 724
16

Tarazi A, Aburrub A, Hijah M. Use of artificial intelligence in neurological disorders diagnosis: A scientometric study. World J Methodol 2025; 15(3): 99403

2025-09-20 | Browse: 6065 | Download: 926
17

Casu C, Inchingolo AM, Orrù G. Interleukin 10 supplement to reduce episodes of recurrent aphthous stomatitis. World J Methodol 2025; 15(3): 99176

2025-09-20 | Browse: 4481 | Download: 692
18

Singh K, Nashwan AJ. Innovative forecasting models for nurse demand in modern healthcare systems. World J Methodol 2025; 15(3): 99162

2025-09-20 | Browse: 3917 | Download: 683
19

Kodali R, Parasar K, Anand U, Singh BN, Kant K, Arora A, Karthikeyan V, Anwar S, Saha B, Wadaskar S. Evidence-based approach for intraabdominal drainage in pancreatic surgery: A systematic review and meta-analysis. World J Methodol 2025; 15(3): 99080

2025-09-20 | Browse: 5143 | Download: 950
20

Al-Beltagi M. Fishing reviewing: A threat to research integrity and credibility. World J Methodol 2025; 15(3): 98795

2025-09-20 | Browse: 4230 | Download: 724
59323 items  Read more >>
Featured Articles
1

Tomassoni DR, Schildkraut T, Ramachandran V, Cooke JC, Sawhney R. Cardiovascular risk assessment and predictors of cardiac decompensation after transjugular intrahepatic portosystemic shunt in patients with cirrhosis. World J Gastroenterol 2025; 31(27): 107740

2025-07-21 | Browse: 14 | Download: 12
2

Tian Y, Zhou HY, Liu ML, Ruan Y, Yan ZX, Hu XH, Du J. Machine learning-based identification of biochemical markers to predict hepatic steatosis in patients at high metabolic risk. World J Gastroenterol 2025; 31(27): 108200

2025-07-21 | Browse: 13 | Download: 13
3

Li S, Zhu C, Tong L, Zheng XM, Rong C, Gao YK, Yuan DC, Wu XW. Correlation between radiomic features of Crohn's disease and secondary loss of response to infliximab. World J Gastroenterol 2025; 31(27): 109459

2025-07-21 | Browse: 14 | Download: 15
4

Kwon YS, Park TY, Kim SE, Park Y, Lee JG, Lee SP, Kim KO, Jang HJ, Yang YJ, Cho BJ. Deep learning-based localization and lesion detection in capsule endoscopy for patients with suspected small-bowel bleeding. World J Gastroenterol 2025; 31(27): 106819

2025-07-21 | Browse: 11 | Download: 16
5

Sharara AI, Alsohaibani FI, Alsaegh A, Al Ejji K, Al Awadhi S, Malfertheiner P, Karam S, Al-Taweel T. First regional consensus on the management of Helicobacter pylori infection in the Middle East. World J Gastroenterol 2025; 31(27): 107138

2025-07-21 | Browse: 15 | Download: 12
6

Butt N, Ali S, Khemani H, Mumtaz K. Acute liver failure etiology, clinical manifestation and outcomes in adults: Experience of tertiary care hospital in Karachi. World J Crit Care Med 2025; 14(3): 105428

2025-07-18 | Browse: 15 | Download: 23
7

Machado C. Jahi McMath case: A comprehensive and updated narrative. World J Crit Care Med 2025; 14(3): 107513

2025-07-18 | Browse: 15 | Download: 18
8

Belal AA, Santos Jr AH, Koratala A, Kazory A. Expanding the boundaries of kidney replacement therapy in patients with liver failure. World J Crit Care Med 2025; 14(3): 105235

2025-07-18 | Browse: 15 | Download: 19
9

Al-Kadi A, Anter A, Rofaeil RR, Sayed-Ahmed MM, Ahmed ASF. Klotho: A multifaceted protector in sepsis-induced organ damage and a potential therapeutic target. World J Crit Care Med 2025; 14(3): 103458

2025-07-18 | Browse: 17 | Download: 21
10

Milionis C, Zoumakis E, Tselebis A, Ilias I. Endocrine issues in critically ill transgender patients: A narrative review. World J Crit Care Med 2025; 14(3): 100660

2025-07-18 | Browse: 17 | Download: 20
11

Yousif Mohamed AM, Salih M, Mohamed M, Abbas AE, Elsiddig M, Osama Omar M, Abdelsalam M, Elhag B, Mohamed N, Eisa Ahmed SH, Ahmed S, Mohamed D, Omar D. Comparative efficacy of cementless bipolar hemiarthroplasty and proximal femoral nail anti-rotation in unstable intertrochanteric fractures: A meta-analysis. World J Orthop 2025; 16(7): 107950

2025-07-17 | Browse: 25 | Download: 27
12

Zhi ZZ, Liu T, Kang J, Zhou FC, Liu XD, He ZM. miR-365 promotes HOXA9-mediated differentiation of mesenchymal stem cells to nucleus pulposus cells by interacting with HIF-1α. World J Orthop 2025; 16(7): 107045

2025-07-17 | Browse: 20 | Download: 74
13

Jones K, Muehlmann AM, Musgrave M, Penrose CT. Short-term survivorship of Truliant® total knee arthroplasty implants utilizing the American Joint Replacement Registry. World J Orthop 2025; 16(7): 106281

2025-07-17 | Browse: 24 | Download: 32
14

Roberts RHR, Gamble C, Malek I. Defensive antibacterial coating in orthopaedic surgery: Current evidence and future direction. World J Orthop 2025; 16(7): 107575

2025-07-17 | Browse: 22 | Download: 32
15

Jeyaraman M, Jeyaraman N, Nallakumarasamy A, Ramasubramanian S, Muthu S. Insights of cartilage imaging in cartilage regeneration. World J Orthop 2025; 16(7): 106416

2025-07-17 | Browse: 19 | Download: 20
16

Lin J, Chen YY, Wang SJ, Zhang Y, Huang HS, Zhang XQ. Epigenetic clocks of female reproductive system aging: Current application and future prospects. World J Obstet Gynecol 2025; 14(2): 108149

2025-07-16 | Browse: 23 | Download: 39
17

Wu SX, Liang XL, Zhu QQ, Wang W, Jiang L, Chen HH, Tian S, Qi M. Altered hippocampal subfield volumes are associated with memory and executive function in patients with type 2 diabetes mellitus. World J Diabetes 2025; 16(7): 104424

2025-07-15 | Browse: 33 | Download: 71
18

Li YF, Wei Y, Li MR, Sun ZZ, Xie WY, Li QF, xie CH, Xiang JY, Tan X, Qiu SJ, Liang Y. Detect the disrupted brain structural connectivity in type 2 diabetes mellitus patients without cognitive impairment. World J Diabetes 2025; 16(7): 103468

2025-07-15 | Browse: 33 | Download: 69
19

Zuo DB, Wang CH, Sang M, Sun XD, Chen GP, Ji KK. Stem cell therapy for diabetes: Advances, prospects, and challenges. World J Diabetes 2025; 16(7): 107344

2025-07-15 | Browse: 28 | Download: 55
20

Rambaran N, Islam MS. Decoding androgen excess in polycystic ovary syndrome: Roles of insulin resistance and other key intraovarian and systemic factors. World J Diabetes 2025; 16(7): 108789

2025-07-15 | Browse: 34 | Download: 58
9699 items  Read more >>
Keyword Search Published Articles Processes
1
Case report
2853
2
Case report
1670
3
Hepatocellular carcinoma
1433
4
Gastric cancer
1008
5
Colorectal cancer
986
6
Inflammatory bowel disease
717
7
COVID-19
705
8
Prognosis
670
9
Liver transplantation
617
10
Ulcerative colitis
555
11
Treatment
552
12
Helicobacter pylori
518
13
Diagnosis
517
14
Crohn’s disease
514
15
Endoscopy
479
16
Cirrhosis
478
17
Meta-analysis
454
18
Pancreatic cancer
444
19
Magnetic resonance imaging
440
20
Surgery
423
70323 items  Read more >>
Reader Comments
1
"Crohn's disease (CD) is a chronic, relapsing inflammatory bowel disease that requires long-term treatment. Infliximab (IFX) plays ..."  [Read more]
"Crohn's disease (CD) is a chronic, relapsing inflammatory bowel disease that requires long-term treatment. Infliximab (IFX) plays an important role in inducing remission and maintaining treatment. However, the high incidence of secondary loss of response (SLOR) poses a significant challenge to disease control. Currently, clinical prediction methods for SLOR are limited, and traditional clinical indicators and imaging examinations are not precise enough for prediction. This study, through radiomics technology, integrates the features of the intestinal wall and creeping fat to develop a prediction model that may help identify high-risk patients in advance. This could facilitate earlier adjustment of treatment plans in clinical practice, prevent disease relapse or exacerbation due to SLOR, and reduce unnecessary treatment delays and waste of medical resources. In terms of research methodology, the retrospective analysis used in this study is feasible in practice and makes full use of existing clinical and imaging data. The clinical independent predictors identified through univariate and multivariate analyses, such as white blood cell count, disease duration, and Harvey-Bradshaw Index, are easily obtainable in daily clinical work and are consistent with the factors we clinically observe to be related to SLOR. This makes the study results more easily applicable in clinical practice. The extraction and analysis of radiomics features are also scientifically sound and reasonable. By considering both the intestinal wall and creeping fat, the study fully takes into account the pathological characteristics of Crohn's disease. Creeping fat, as one of the characteristic pathological changes of CD, is increasingly recognized for its role in disease progression and treatment response. Including it in the analysis provides new insights into understanding the pathophysiological mechanisms of CD. The research results are encouraging. The combined prediction model shows good predictive performance in both the training and validation cohorts, indicating high predictive accuracy. This means that the model is highly reliable in practical applications and can provide accurate SLOR risk assessments for clinicians. Through this model, patients can be divided into high-risk and low-risk subgroups to achieve individualized treatment management. For high-risk patients, we can strengthen monitoring, shorten follow-up intervals, and adjust treatment plans in a timely manner, such as increasing IFX dosage or shortening dosing intervals. For low-risk patients, the standard treatment plan can be maintained to avoid overtreatment. This individualized treatment strategy is expected to improve treatment outcomes and patient prognosis. However, the study also has some limitations. The sample size is relatively small, with only 220 patients from two centers included, which may limit the generalizability of the model. In actual clinical applications, patients from different regions and medical centers may vary, so further validation of the model's stability and accuracy is needed in larger-scale multicenter studies. In addition, the study did not include some biomarkers that may have predictive value for SLOR, such as fecal calprotectin. These biomarkers are commonly used in clinical practice to assess intestinal inflammation activity. Including them in the prediction model may further improve its predictive performance. Future studies should consider integrating more clinical indicators and biomarkers to develop a more comprehensive prediction model. Overall, this study provides new ideas and tools for the management of Crohn's disease. As a gastroenterologist, I look forward to further validation and application of this study in clinical practice. Through radiomics technology, we may be able to more accurately predict secondary loss of response to IFX, thereby providing more individualized treatment plans for patients and improving the long-term prognosis of patients with Crohn's disease. At the same time, I also hope that future studies can overcome existing limitations and further optimize the prediction model to provide stronger support for clinical treatment decisions. "  [Collapse]
Li S, Zhu C, Tong L, Zheng XM, Rong C, Gao YK, Yuan DC, Wu XW. Correlation between radiomic features of Crohn's disease and secondary loss of response to infliximab. World J Gastroenterol 2025; 31(27): 109459
2
"This study aims to address the issues of time-consuming interpretation and reliance on the experience of readers when using small ..."  [Read more]
"This study aims to address the issues of time-consuming interpretation and reliance on the experience of readers when using small bowel capsule endoscopy (SBCE) to evaluate obscure gastrointestinal bleeding (OGIB). An AI model was developed to automatically distinguish the small intestine, stomach, and colon, and diagnose small intestinal abnormalities such as erosions, ulcers, vascular malformations, and bleeding. Using 87,005 images from 101 SBCE videos as the dataset, the researchers built models based on DenseNet161 and DenseNet201 convolutional neural networks, trained them through preprocessing and data augmentation, and validated their clinical utility on 32 external videos. The results showed that the model achieved over 99% accuracy in organ localization (AUC > 0.99) and 99.4% to 99.9% accuracy in lesion detection in internal testing. The AI-assisted reading time was significantly reduced to an average of 8.7 minutes (compared to 53.9 minutes traditionally), and the diagnostic performance was comparable to traditional reading. The discussion pointed out that the model significantly improved efficiency while maintaining high accuracy, but limitations included the dataset mainly consisting of Asian patients, being limited to a specific platform (MiroCam), having a small external validation sample (32 cases), incomplete coverage of lesion types, and the lack of advanced image enhancement techniques. The conclusion is that AI-assisted SBCE reading can reduce time and maintain performance, making it suitable for clinical implementation to improve consistency and efficiency. Readers believe this can help clinicians improve work efficiency and reduce misdiagnosis. Future research should expand the sample size, cover more lesion types, adapt to different platforms, and integrate advanced technologies to optimize diagnostic capabilities. "  [Collapse]
Kwon YS, Park TY, Kim SE, Park Y, Lee JG, Lee SP, Kim KO, Jang HJ, Yang YJ, Cho BJ. Deep learning-based localization and lesion detection in capsule endoscopy for patients with suspected small-bowel bleeding. World J Gastroenterol 2025; 31(27): 106819
3
"The manuscript is well organized, written in clear language and using scientific terms. The information presented is accurate, but ..."  [Read more]
"The manuscript is well organized, written in clear language and using scientific terms. The information presented is accurate, but there are several gaps, including the very small sample size which makes the results not significant. For the medical treatment to be of an impact significance, the study should be conducted on an importantly significant sample size. Also, the factors studied are important, but a wider variety of factors should be taken into consideration to give a powerful significant for the study. Aswell, the recurrence rate of VAs after sirolimus treatment is a very crucial factor. This factor is important to determine the efficacy of the treatment and its impact on controlling the medical condition. Aswell, it is important to present the long-term adverse effects of sirolimus treatment and emphasize on gastrointestinal, cardiac, and pulmonary side effects based on its mechanism of action. In conclusion, sirolimus is an effective medically treatment of vascular anomalies, but the limitations of the study classify it as not significant due mainly to the very small sample size included. "  [Collapse]
Sun Q, Wu JC, Chen X, Li DH, Li BR, Xiao NJ, Wang XY, Tu XZ, Ning SB, Sun T. Efficacy and safety of sirolimus in the treatment of gastrointestinal angiodysplasias. World J Gastroenterol 2025; 31(25): 105677
4
"The authors gave a comprehensive review of sedation protocols, factors associated with successful cannulation, various biliary ..."  [Read more]
"The authors gave a comprehensive review of sedation protocols, factors associated with successful cannulation, various biliary cannulation techniques, accessories, potential complications related to ERCP, and endoscopic ultrasound-guided ERCP. They also gave a fantastic pictorial representation of the same. However, the authors have not included the Erlanger technique and Burdick’s technique of cannulation, which can be used in appropriate settings. One additional variation in the technique described for free-hand access sphincterotomy using a needle knife, which is employed in our institute, involves a change in direction. Specifically, rather than cephalad, if the direction is caudal from the roof, the complication rates may decrease, with an increase in the rate of cannulation. We also described this variation in this letter: https://doi.org/10.1007/s12664-025-01772-w. Overall, this review provided an exhaustive review of the available literature and techniques for improving successful biliary cannulation. "  [Collapse]
Ismail A, Abdelwahab MM, Ozercan M, Elnahas O, Bahcecioglu IH, Yalniz M, Tawheed A. Strategies for achieving successful cannulation in endoscopic retrograde cholangiopancreatography: A technical overview. World J Gastrointest Endosc 2025; 17(7): 107810
5
"To the Editor, We read with great interest the article by Ren et al. [1], published in World Journal of Gastroenterology, which ..."  [Read more]
"To the Editor, We read with great interest the article by Ren et al. [1], published in World Journal of Gastroenterology, which investigates serum exosomal hsa-let-7f-5p as a potential non-invasive biomarker for detecting metastatic pancreatic cancer. The research presents a compelling advancement in the molecular diagnostics of one of the most aggressive malignancies. This study is both timely and relevant, considering the dismal survival rates in pancreatic cancer due to delayed diagnosis and poor response to conventional therapies [1, 2]. In this letter, we aim to provide a critical appraisal of the study design and methodology, place the findings in the context of the current scientific literature, evaluate the novelty and translational potential of hsa-let-7f-5p, and recommend avenues for future research. Ren et al. successfully shown that hsa-let-7f-5p is considerably higher in the serum exosomes of patients with metastatic pancreatic cancer than in those with localized illness. They discovered 42 differently expressed miRNAs using high-throughput sequencing and verified hsa-let-7f-5p using qRT-PCR, providing strong support for their result. These findings are consistent with a growing body of data that exosomal miRNAs, due to their stability in circulation and tumor selectivity, have intriguing diagnostic capacities in malignancies [3-5]. The reason for using serum exosomal miRNAs as biomarkers is widely understood. Exosomes are small vesicles released by nearly all cells, including tumor cells, that carry molecular cargo specific to their cell of origin. Previous research has demonstrated the usage of exosomal miRNAs such as miR-21, miR-1246, and miR-10b in pancreatic cancer [6-8]. However, few studies have focused on distinguishing metastatic from non-metastatic pancreatic cancer, which is an important clinical differential. One of the major strengths of Ren et al.'s work is the comprehensive pipeline employed for exosome isolation, characterization, and miRNA profiling. The authors validated exosomes using well-established techniques such as transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and western blotting. This multiparametric validation boosts the credibility of their results. The let-7 family of miRNAs is known for its tumor-suppressive and context-dependent oncogenic roles. While most members inhibit proliferation and metastasis, emerging evidence shows that specific let-7 members, such as let-7f-5p, can be upregulated in certain cancers and are associated with worse outcomes [9]. Ma et al. reported that hsa-let-7f-5p was highly expressed in pulmonary carcinoid tumors and regulated HMGA2, a protein involved in chromatin remodeling and EMT [10]. In prostate cancer, Valera et al. found higher hsa-let-7f-5p expression in older patients, suggesting its possible role in tumor progression with age [11]. Ren et al.’s results extend these findings to pancreatic cancer, highlighting the utility of hsa-let-7f-5p as a stage-specific biomarker rather than merely a diagnostic one. The strength of hsa-let-7f-5p as a diagnostic marker for metastasis is promising, but a comparative evaluation with other known biomarkers would enrich the discussion. For instance: miR-21 has been extensively validated as an oncogenic miRNA in pancreatic cancer and is known to promote invasion and resistance to gemcitabine [12]. miR-155 and miR-196a have been associated with poor prognosis and have been considered for early diagnostic panels [13]. In this investigation, I discovered many weaknesses. The first is a small sample size (n=36), and the lack of longitudinal follow-up data limits the findings' generalizability and prognostic application. Multicenter trials with larger and more diverse cohorts are required to verify hsa-let-7f-5p as a clinical biomarker. Furthermore, only four miRNAs were validated, leaving the other 38 (including 34 unique ones) untested. Some of these may have even greater discriminatory strength or synergistic benefit when integrated into multi-miRNA signatures, a method that has demonstrated increased accuracy in other malignancies. Moreover, the biological activities of hsa-let-7f-5p in encouraging metastasis warrant additional investigation. Functional research using in vitro invasion tests and in vivo metastasis models could help determine whether this miRNA is simply a marker or a mechanistic component to metastatic spread. Another topic to look at is if exosomal hsa-let-7f-5p levels alter in response to treatment. If so, this could lead to real-time, non-invasive therapy monitoring, which is critical in pancreatic oncology. The authors recommend using hsa-let-7f-5p in routine surveillance to detect metastases in pancreatic cancer patients, possibly in conjunction with imaging. We support this objective and urge that commercial assay kits be developed and clinically validated in accordance with CLIA/CAP requirements. Given that the majority of pancreatic cancer patients come with late-stage disease, a non-invasive technology for early detection of metastases can have a considerable impact on treatment decisions, such as avoiding non-curative surgery or starting systemic therapy earlier. Furthermore, including such biomarkers into AI-driven diagnostic pipelines has the potential to improve risk classification algorithms and customize treatment regimens, in line with precision medicine concepts. Ren et al. provide a valuable contribution to the field by identifying serum exosomal hsa-let-7f-5p as a potential diagnostic biomarker for metastatic pancreatic cancer. The study is technically sound, analytically robust, and biologically plausible. Nevertheless, broader validation, mechanistic studies, and clinical comparisons with existing biomarkers are necessary to cement its place in clinical practice. We commend the authors for their innovative and methodologically rigorous work and look forward to seeing the next phase of this research. Their findings not only enhance our understanding of pancreatic cancer metastasis but also pave the way for more personalized, non-invasive diagnostic tools in oncology. Reference: 1. Verma, H.K., et al., A Retrospective Look at Anti-EGFR Agents in Pancreatic Cancer Therapy. Curr Drug Metab, 2019. 20(12): p. 958-966. 2. Golivi, Y., et al., Small molecular inhibitors: Therapeutic strategies for pancreatic cancer. Drug Discovery Today, 2024. 29(7): p. 104053. 3. Wu, J. and Z. Shen, Exosomal miRNAs as biomarkers for diagnostic and prognostic in lung cancer. Cancer Med, 2020. 9(19): p. 6909-6922. 4. Lohajová Behulová, R., et al., Circulating exosomal miRNAs as a promising diagnostic biomarker in cancer. Physiol Res, 2023. 72(S3): p. S193-s207. 5. Li, C., et al., The role of Exosomal miRNAs in cancer. Journal of Translational Medicine, 2022. 20(1): p. 6. 6. Uddin, M.H., et al., Exosomal microRNA in Pancreatic Cancer Diagnosis, Prognosis, and Treatment: From Bench to Bedside. Cancers (Basel), 2021. 13(11). 7. Jafari, A., et al., The Emerging Role of Exosomal miRNAs as Biomarkers for Early Cancer Detection: A Comprehensive Literature Review. Technol Cancer Res Treat, 2023. 22: p. 15330338231205999. 8. Xu, Y., et al., The role of exosomal microRNAs in pancreatic cancer. Stem Cell Investigation, 2020. 7. 9. Gilles, M.E. and F.J. Slack, Let-7 microRNA as a potential therapeutic target with implications for immunotherapy. Expert Opin Ther Targets, 2018. 22(11): p. 929-939. 10. Ma, Q., et al., HMGA2 promotes cancer metastasis by regulating epithelial-mesenchymal transition. Front Oncol, 2024. 14: p. 1320887. 11. Valera, V.A., et al., microRNA Expression Profiling in Young Prostate Cancer Patients. J Cancer, 2020. 11(14): p. 4106-4114. 12. Chen, C., L. Demirkhanyan, and C.S. Gondi, The Multifaceted Role of miR-21 in Pancreatic Cancers. Cells, 2024. 13(11). 13. Yuan, W., et al., New combined microRNA and protein plasmatic biomarker panel for pancreatic cancer. Oncotarget, 2016. 7(48). "  [Collapse]
Ren S, Song LN, Zhao R, Tian Y, Wang ZQ. Serum exosomal hsa-let-7f-5p: A potential diagnostic biomarker for metastatic pancreatic cancer detection. World J Gastroenterol 2025; 31(26): 109500
6
"This paper provides an interesting exploration of Chinese medicine monomers in regulating autophagy for the prevention and treatment ..."  [Read more]
"This paper provides an interesting exploration of Chinese medicine monomers in regulating autophagy for the prevention and treatment of HCC. The review highlights the potential of various compounds in modulating key signaling pathways involved in autophagy, offering new insights into the development of therapeutic strategies for HCC. The integration of traditional Chinese medicine with modern pharmacology is an exciting approach that could open up novel treatment avenues for cancer. However, the study mainly focuses on preclinical findings, and the lack of clinical trial data limits its immediate application. Despite this, the research is highly relevant for both basic and clinical oncology, offering promising directions for future studies and therapeutic development. "  [Collapse]
Zheng SH, Xue TY, Wang QY, Ye YA, Zhang P. Chinese medicine monomers for hepatocellular carcinoma: New ideas related to autophagy. World J Gastroenterol 2025; 31(26): 106113
7
"This paper provides valuable insights into the potential of endocytoscopy as a real-time diagnostic tool for UC. The study highlights ..."  [Read more]
"This paper provides valuable insights into the potential of endocytoscopy as a real-time diagnostic tool for UC. The study highlights the effectiveness of the ECSS and ELECT score in assessing both endoscopic and histological activity. The findings suggest that endocytoscopy can offer a faster, non-invasive alternative to traditional histopathological methods, potentially improving clinical decision-making in UC management. However, the study is limited by its small sample size and single-center design, which may affect the generalizability of the results. Despite these limitations, the paper shows the promising role of endocytoscopy in assessing UC activity, with potential implications for more efficient and timely disease management in clinical practice. "  [Collapse]
Chaemsupaphan T, Shir Ali M, Fung C, Paramsothy S, Leong RW. Endocytoscopy in real-time assessment of histological and endoscopic activity in ulcerative colitis. World J Gastrointest Endosc 2025; 17(7): 108082
8
"This paper provides valuable insights into the complementary roles of VCE and SBE in diagnosing small bowel disorders. By comparing ..."  [Read more]
"This paper provides valuable insights into the complementary roles of VCE and SBE in diagnosing small bowel disorders. By comparing both techniques, the study highlights VCE’s superiority for non-invasive initial evaluations and SBE’s utility in therapeutic interventions and obtaining histopathological confirmation. The findings are clinically significant, especially in managing obscure gastrointestinal bleeding and small bowel tumors, offering a more structured approach for clinicians. However, the study could benefit from a discussion on emerging technologies and larger, prospective studies to further validate its findings. Overall, this paper is a useful reference for clinicians involved in small bowel diagnostics. "  [Collapse]
Gadour E, Miutescu B, Okasha HH, Ghiuchici AM, AlQahtani MS. Diagnostic yield of video capsule endoscopy vs simple balloon enteroscopy in small intestinal disorders: A systematic review. World J Gastrointest Endosc 2025; 17(7): 108264
9
"### Review of the Article “Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in ..."  [Read more]
"### Review of the Article “Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in metabolic dysfunction-associated steatotic liver disease” published in the World Journal of Gastroenterology This article represents a significant advancement in the non-invasive diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD) and offers valuable insights for clinical practice. #### Clinical Application Value The study introduces a non-invasive assessment method based on multiparametric ultrasound, which holds great significance for clinical practice. Given the large number of MASLD patients, traditional liver biopsy is not only costly but also associated with sampling errors and risks of complications. The introduction of multiparametric ultrasound provides clinicians with a safer and more convenient diagnostic tool, effectively reducing the need for liver biopsies and minimizing patient discomfort and medical costs. #### Innovation For the first time, this study compares viscosity measurements (Vi.PLUS) with the histopathological features of MASLD and finds that viscosity is closely related to the degree of inflammation and ballooning in MASH. This finding offers a new perspective for the non-invasive diagnosis of MASLD and paves the way for future research and clinical applications. #### Methodological Rigor The study employs a single-center, prospective, cross-sectional design with 120 patients, all of whom underwent liver biopsy as the reference standard. This rigorous study design and methodology ensure the reliability and scientific validity of the results. #### Practicality of the Results The study demonstrates that the VAS-MASH-US score, based on multiparametric ultrasound, has good sensitivity and specificity for diagnosing MASH. This scoring system provides clinicians with a practical tool to better identify high-risk patients who need liver biopsy, while reducing unnecessary invasive examinations for low-risk patients. #### Limitations of the Study Despite the significant findings, the study has some limitations. For example, it is a single-center study with a relatively small sample size, and the results have not yet been validated in an independent cohort. Additionally, differences in ultrasound equipment and techniques across centers may affect the generalizability of the results. #### Implications for Future Research This study provides new ideas and methods for the non-invasive diagnosis of MASLD, but further research is needed to validate these findings. For instance, multicenter studies in larger populations could verify the universality and accuracy of the VAS-MASH-US score. Moreover, exploring the combination of other non-invasive techniques with multiparametric ultrasound could further improve the diagnostic accuracy of MASLD. In summary, this article represents an important step forward in the non-invasive diagnosis of MASLD. Its innovation and practicality are commendable. It is hoped that more research will be conducted in the future to further refine this field and provide better medical services for MASLD patients. "  [Collapse]
Liguori A, Ainora ME, Di Gialleonardo L, Viceconti N, Petrucci L, Esposto G, Giustiniani MC, Mignini I, Borriello R, Galasso L, Paratore M, Garcovich M, Riccardi L, Pompili M, Grieco A, Gasbarrini A, Miele L, Zocco MA. Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(25): 105518
10
"Good case report of involvement of thyroid cartilage, however, it is a very rare incidence. Language quality is good. Content is ok ..."  [Read more]
"Good case report of involvement of thyroid cartilage, however, it is a very rare incidence. Language quality is good. Content is ok IHC report images should also be included to solidify the diagnosis and not just mentioning the report of IHC findings. Study stated to look for the distant metastasis including the thyroid/cartilage. However, hematogenous spread to more common distant organ should be more focused on rather than the rare ones. Especially-- liver, bone etc. Metastasis to thyroid cartilage- a poor prognostic factor--mentioned in the study. However, could not get any information/data for that "  [Collapse]
Ai MM, Lin T, Guo RY, Zhang YY, Yu F. Unexpected metastasis of thyroid cartilage involvement from lung adenocarcinoma: A case report. World J Clin Cases 2025; 13(25): 107471
11
"Good case report of involvement of thyroid cartilage, however, it is a very rare incidence. Language quality is good. Content is ok ..."  [Read more]
"Good case report of involvement of thyroid cartilage, however, it is a very rare incidence. Language quality is good. Content is ok IHC report images should also be included to solidify the diagnosis and not just mentioning the report of IHC findings. Study stated to look for the distant metastasis including the thyroid/cartilage. However, hematogenous spread to more common distant organ should be more focused on rather than the rare ones. Especially-- liver, bone etc. Metastasis to thyroid cartilage- a poor prognostic factor--mentioned in the study. However, could not get any information/data for that. "  [Collapse]
Ma TT, Lyu HR. Post-endoscopic retrograde appendicitis therapy stent impaction leading to exacerbation of appendicitis: A case report. World J Clin Cases 2025; 13(25): 106587
12
"tertiary care hospital over the last 7 years from the Himalayan and Sub-Himalayan regions of India. Studys aim--To analyze the ..."  [Read more]
"tertiary care hospital over the last 7 years from the Himalayan and Sub-Himalayan regions of India. Studys aim--To analyze the demography, clinical presentation, complications, and mortality risk factors in presumptive leptospirosis patients admitted--- was fulfilled, however, limited to one single center study and observation only. 2018-2024 data were collected based on Modified Faine’s criteria with ELISA diagnosis. \ Sample size is small. 62 number Study found- equal number of distribution of cases irrespective of sex. Complications include thrombocytopenia and liver involvement and AKI. MDS was serious complication observed in 66% of cases. Studies have also highlighted that early administration of antibiotics and aggressive supportive care can improve survival outcomes in critically ill patients with leptospirosis Limitation—only single center study with possible some selection bias. Overall Language quality and content-- Excellent. "  [Collapse]
Das D, Ponnampurathu S, Panda PK, Mathuria YP. Different clinical profile of leptospirosis in a tertiary care Indian hospital: A Himalayan experience. World J Clin Cases 2025; 13(25): 106335
13
"Study conducted from 1985 to 2022--total 47 patients included with PDTC. some of them lost on follow up. Good analysis of risk factors ..."  [Read more]
"Study conducted from 1985 to 2022--total 47 patients included with PDTC. some of them lost on follow up. Good analysis of risk factors and outcome. Good standard of article The scientific quality of very good The language quality is also professional and clear. The data analysis and charts are upto the mark. "  [Collapse]
Hsu CW, Hsueh C, Lu YL, Hsu CJ, Wong RJ, Lin SF. Risk factors and outcomes of metastatic poorly differentiated thyroid carcinoma. World J Clin Cases 2025; 13(25): 105204
14
"This paper reports on a clinical trial assessing the efficacy and safety of sirolimus in the treatment of gastrointestinal ..."  [Read more]
"This paper reports on a clinical trial assessing the efficacy and safety of sirolimus in the treatment of gastrointestinal angiodysplasia (GIAD). The results indicate that sirolimus is effective in reducing bleeding, improving hemoglobin levels, decreasing transfusion dependence, and improving lesion outcomes. Additionally, the adverse effects were mild and manageable. However, it should be noted that while patients with various underlying conditions were included, those with chronic kidney disease were not represented. This is a concern, as patients with chronic kidney disease often experience recurrent gastrointestinal bleeding due to angiodysplasia. Further studies involving a larger number of patients, including those with chronic kidney disease, are warranted. "  [Collapse]
Sun Q, Wu JC, Chen X, Li DH, Li BR, Xiao NJ, Wang XY, Tu XZ, Ning SB, Sun T. Efficacy and safety of sirolimus in the treatment of gastrointestinal angiodysplasias. World J Gastroenterol 2025; 31(25): 105677
15
"This paper provides an interesting exploration of the gut microbiota and its potential role in autoimmune overlap syndrome (OS), ..."  [Read more]
"This paper provides an interesting exploration of the gut microbiota and its potential role in autoimmune overlap syndrome (OS), combining features of autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC). The study integrates multi-omics data, focusing on microbial profiles and serum metabolites, to provide new insights into the pathophysiology of OS. The findings are clinically relevant, particularly in the context of identifying biomarkers for earlier and non-invasive diagnosis of OS, which could improve clinical management. However, the study is limited by its small sample size and lack of a healthy control group, which restricts the generalizability of the results. Despite these limitations, the paper opens up promising avenues for future research in microbiota-based diagnostics and therapeutic strategies for autoimmune liver diseases. "  [Collapse]
Wang Q, Sun LN, Shi H, Ma XY, Gao W, Xu B, Lin X, Liu YM, Huang CY, Jin RH. Multi-omics analysis reveals gut microbiota-metabolite interactions and their association with liver function in autoimmune overlap syndrome. World J Gastroenterol 2025; 31(25): 106371
16
"This study presents a comprehensive investigation into the use of multiparametric ultrasound (US) for the non-invasive assessment ..."  [Read more]
"This study presents a comprehensive investigation into the use of multiparametric ultrasound (US) for the non-invasive assessment of liver steatosis, fibrosis, and inflammation in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). The authors employed various advanced ultrasound techniques, including 2D shear-wave elastography (SWE), sound speed and attenuation imaging, and viscosity plane-wave ultrasound (Vi.PLUS), alongside traditional methods like FibroScan. The study's findings are promising, demonstrating that multiparametric ultrasound can effectively assess liver conditions such as fibrosis and steatosis, and even disease activity related to inflammation and ballooning. The diagnostic performance of the viscosity index (Vi.PLUS) and the VAS-MASH-US score was found to be good, especially for identifying patients with metabolic dysfunction-associated steatohepatitis (MASH). This approach could help reduce unnecessary liver biopsies, thereby minimizing costs and procedural risks, which is a significant clinical advantage. "  [Collapse]
Liguori A, Ainora ME, Di Gialleonardo L, Viceconti N, Petrucci L, Esposto G, Giustiniani MC, Mignini I, Borriello R, Galasso L, Paratore M, Garcovich M, Riccardi L, Pompili M, Grieco A, Gasbarrini A, Miele L, Zocco MA. Multiparametric ultrasound for non-invasive assessment of liver steatosis, fibrosis, and inflammation in metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(25): 105518
17
"Hepatocellular carcinoma (HCC) remains a major global health burden, ranking as the sixth most common cancer and the third leading ..."  [Read more]
"Hepatocellular carcinoma (HCC) remains a major global health burden, ranking as the sixth most common cancer and the third leading cause of cancer-related mortality worldwide. Despite advances in surveillance, early diagnosis, and the emergence of molecular-targeted and immunotherapeutic agents, the prognosis for many patients with HCC remains poor. This is particularly true in advanced-stage disease, where therapeutic resistance and immune escape mechanisms hinder durable responses. As our understanding of HCC pathogenesis deepens, the tumor microenvironment (TME) has emerged as a critical determinant of disease progression and therapeutic outcome. Among the key regulators in this microenvironment are galectins (Gals)—a family of glycan-binding proteins with various immunomodulatory and tumor-regulatory functions. Gal-1, Gal-3, Gal-4, and Gal-9 have attracted significant attention for their diverse roles in HCC. These proteins guide important cellular processes vital for tumor development, including inflammation, immune evasion, angiogenesis, epithelial–mesenchymal transition (EMT), proliferation, and metastasis. What sets galectins apart is their functional duality—their effects depend on their cellular location, expression levels, and the tumor microenvironment (TME). This complexity highlights their potential as both biomarkers and therapeutic targets in HCC. They coordinate processes like inflammation, angiogenesis, EMT, tumor growth, and spread. Importantly, galectins display dynamic, context-dependent behavior, capable of exerting both tumor-promoting and tumor-inhibiting effects depending on their expression, cellular localization, and the surrounding microenvironment. Recent studies, including the comprehensive review by Gajovic and colleagues (WJG 2025; 31:107260), highlight the diverse functions of Galectins in liver cancer. For instance, Gal-1 and Gal-3 are consistently associated with aggressive tumor features such as vascular invasion, immunosuppression, and poor prognosis. Conversely, Gal-4 and Gal-9 appear as favorable prognostic indicators in specific HCC subtypes, possibly due to their roles in immune activation and metastasis suppression. This duality not only reflects the complexity of Galectin biology but also encourages the development of improved biomarkers and personalized therapeutic strategies. The current therapeutic landscape of HCC—although expanded by immune checkpoint inhibitors and molecularly targeted agents—remains inadequate for many patients, especially those with advanced disease. In this context, Galectin-targeted therapies show considerable promise. Gal-3 inhibitors and Gal-3C fusion proteins, for example, are actively being studied for their ability to reverse immune suppression, disrupt tumor–stromal interactions, and improve the effectiveness of existing treatments. Meanwhile, profiling Galectin expression may help predict treatment responses and guide personalized therapy strategies. Elevated levels of Gal-1 and Gal-3 in serum or tumor tissue have consistently been associated with aggressive clinical features, such as vascular invasion, immune evasion, and poor overall survival. Conversely, Gal-4 and Gal-9 expression have been linked to favorable prognostic indicators in some patient groups, highlighting the biological diversity of HCC and the complex roles that galectins play in disease progression. The therapeutic implications are equally compelling. Galectin-targeted agents—such as Gal-3 inhibitors and Gal-3C fusion proteins—are being studied for their ability to modify the TME, boost anti-tumor immunity, and overcome resistance to current therapies. At the same time, integrating galectin profiling into clinical practice could improve risk assessment, enhance prognostic models, and support more personalized treatment approaches. However, these promising advancements must be accompanied by rigorous clinical validation. The dual and sometimes conflicting roles of galectins in cancer emphasize the importance of context—what may be beneficial in one cellular environment could be detrimental in another. Large-scale, well-controlled clinical trials and mechanistic research are critical for fully understanding the therapeutic potential of galectin modulation in HCC. Galectins are an area of study within the field of HCC biology and therapeutics that has not been extensively researched. In addressing treatment resistance and disease heterogeneity, galectins have potential for the development of biomarkers and targeted therapies. Including galectins in future HCC management strategies may contribute to more effective and personalized treatment methods. "  [Collapse]
Gajovic NM, Jovanovic IP, Jocic MV, Stojanovic B, Corovic IF, Todorovic N, Simovic Markovic BJ, Amedei A. Exploring the impact of galectins on liver cancer: From immunopathogenesis to potential targets. World J Gastroenterol 2025; 31(25): 107260
18
"This study demonstrates that reduced NRF2 activity contributes to ER stress and senescence in adipose-derived mesenchymal stem cells ..."  [Read more]
"This study demonstrates that reduced NRF2 activity contributes to ER stress and senescence in adipose-derived mesenchymal stem cells (ASCs) from hypertrophic obese mice, primarily through downregulation of MFN2. The use of multiple approaches, including NRF2/MFN2 knockdown and rescue, ChIP-qPCR, Co-IP, immunofluorescence, and IP-MS, adds robustness to the findings. Importantly, the functional relevance is strengthened by transplantation experiments, showing that disruption of NRF2 or MFN2 impairs the therapeutic potential of ASCs in insulin resistance, highlighting translational significance. However, while the authors suggest an interaction between MFN2 and BIP, the evidence remains indirect. Biochemical confirmation such as GST pull-down or FRET would be needed to verify a direct interaction. Additionally, NRF2 may affect ER stress and senescence through other targets beyond MFN2, which were not explored in this study. Future work should aim to clarify the structural basis of MFN2–BIP interaction and its functional consequences. Given the known role of MFN2 in mitochondrial dynamics and ER-mitochondrial tethering, investigating how this axis influences mitochondrial morphology, mitochondria-associated membranes integrity, and calcium signaling could provide further mechanistic insights. "  [Collapse]
Fang J. Reduced NRF2/Mfn2 activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells in hypertrophic obese mice. World J Stem Cells 2025; 17(6): 104367
19
"Dear Editor, I read with great interest the editorial by Papadakos et al. on the evolving immunotherapeutic landscape in ..."  [Read more]
"Dear Editor, I read with great interest the editorial by Papadakos et al. on the evolving immunotherapeutic landscape in gastrointestinal stromal tumors (GISTs). The authors provide a comprehensive overview of the tumor microenvironment (TME), challenges in immunotherapy response, and emerging strategies. I would like to offer several complementary insights and suggest future directions for translational and clinical research. 1. Stratifying GISTs Through Immune Profiling: The authors rightly emphasize the immunosuppressive TME in GISTs. Building on this, emerging evidence from proteomic and transcriptomic studies supports the existence of distinct immune clusters ranging from inflamed “hot” tumors (TLS⁺/B-cell-rich) to immune-desert “cold” phenotypes. These immune subtypes have shown clear prognostic and predictive value for checkpoint inhibitor response, with objective response rates reaching 50% in TLS-rich subgroups. Integration of spatial profiling and CXCL13 expression as biomarkers may refine patient selection for PD-1/PD-L1 blockade. 2. 2. Rationale for Combination Strategies: While the editorial correctly notes the modest activity of ICIs in unselected patients, combinatorial approaches offer promise. For example, pegylated interferon-alpha-2b (PegIFNα2b) in conjunction with imatinib significantly enhances immune infiltration and suppresses PI3K/mTOR signaling, achieving remarkable response rates in early trials. Similarly, imatinib’s ability to reverse immunosuppression via IDO downregulation and Treg reduction provides a mechanistic rationale for synergy with ICIs, particularly in PDGFRA D842V-mutant GISTs. 3. Targeting Tumor Antigens and TME Components: Antibody-based therapies like SR1 (anti-KIT) have demonstrated macrophage-dependent cytotoxicity even in imatinib-resistant models. This offers a novel route to bypass TKI resistance. Additionally, novel modalities such as bispecific antibodies targeting KIT or PDGFRA in conjunction with CD3⁺ T cell engagement may overcome immune exclusion in “cold” tumors. 4. Addressing IDO Inhibitor Failures: The editorial notes the challenges with IDO1-targeted therapies. We propose that resistance may stem from spatial heterogeneity and compensatory activation of AhR and TDO2 pathways. Poly-pathway blockade, rather than IDO inhibition alone, may be essential to overcome this resistance. 5. Moving Forward: Future success in GIST immunotherapy will depend on Immune subtyping based on TLS, B cell density, and proteomic clusters (Im-I to Im-IV), Rational combination trials of TKIs + ICIs ± TME-modifying agents, Validation of biomarkers such as CXCL13, CD276, and KIT-derived neoantigens in prospective cohorts. In conclusion, the editorial provides an excellent foundation for discourse. We advocate for multi-center, biomarker-driven clinical trials to translate these emerging insights into tailored immunotherapy regimens for GIST patients. Sincerely, Fen Wang Oncology Department, Peking University Shenzhen Hospital. "  [Collapse]
Papadakos SP, Argyrou A, Karniadakis I, Vogli S, Theocharis S. Immunotherapy in gastrointestinal stromal tumors: Current landscape and future horizons. World J Clin Oncol 2025; 16(6): 104314
20
"Pulmonary fibrosis (PF), a chronic and fatal lung disease affecting millions of people worldwide, urgently needs more effective means. ..."  [Read more]
"Pulmonary fibrosis (PF), a chronic and fatal lung disease affecting millions of people worldwide, urgently needs more effective means. In this paper, the effect of cells vesicles in improving PF was verified through cell lines and rat models, and the possible pathways through which this effect was exerted were investigated. Anyway, there are still some aspects of the article that deserve further discussion. Most importantly, whether the therapeutic effect is exerted through the said signaling pathway needs to be further confirmed. In addition, the text has problems such as writing errors, suspected incompleteness of ethics, and relatively weak research significance. "  [Collapse]
Wang LL, Ouyang MY, Yang ZE, Xing SN, Zhao S, Yu HY. Mesenchymal stem cells-derived exosomes alleviate radiation induced pulmonary fibrosis by inhibiting the protein kinase B/nuclear factor kappa B pathway. World J Stem Cells 2025; 17(6): 106488
1008 items  Read more >>
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