Baishideng Publishing Group

Jiang Q, Liu WD, Hui WJ, Kong WJ, Feng Y, Kuerbanjiang A, Huang XL, Gao F. Prevalence and risk factors of Helicobacter pylori infection in Xinjiang Uygur Autonomous Region: A cross-sectional study of all age groups. World J Gastroenterol 2025; 31(21): 106033

"The quality of the journal is excellent. I would like to express my gratitude to the external reviewers for their detailed comments, ..." [Read more]

"The quality of the journal is excellent. I would like to express my gratitude to the external reviewers for their detailed comments, which have greatly improved the quality of my article. My research has also become more scientific and specific. I will recommend my classmates around me to submit their articles. Thank you again. The submission to the journal is smooth and convenient, and the response speed is very prompt. The experience is excellent. " [Collapse]

He ZY, Cui T, Cui ZQ, Yan HX, Chen MX, Luo H. Effects of modified Yokoyama surgery combined with medial rectus muscle recession on esotropia in highly myopia athletes. World J Clin Cases 2025; 13(21): 104918

"This journal is wonderful. I satisfied with this journal. We think the process from proper peer review to editing is extremely speedy. ..." [Read more]

"This journal is wonderful. I satisfied with this journal. We think the process from proper peer review to editing is extremely speedy. Thank you. I sincerely hope that this journal will continue to grow in the future. Kind regards.We hope that the impact factor will encourage more people to read the papers published in this journal. " [Collapse]

Sakai Y, Tsuyuguchi T, Kumagai J, Ohyama H, Kaiho T, Ohtsuka M, Kato N. Efficacy of elobixibat for elderly patients with chronic constipation in a clinic. World J Gastrointest Pharmacol Ther 2025; 16(2): 105801

"A truly excellent submission experience. Thank you to the editors for your contribution to this article.Editorial communication ..." [Read more]

"A truly excellent submission experience. Thank you to the editors for your contribution to this article.Editorial communication remained transparent at every stage, with no hidden fees or unexpected charges. We believe the overall experience could be further improved if the total manuscript processing time were shortened, which would enhance author satisfaction and potentially attract more high-quality submissions to the journal. " [Collapse]

Wang SY, Gao JC, Wu SD. Artificial intelligence for reducing missed detection of adenomas and polyps in colonoscopy: A systematic review and meta-analysis. World J Gastroenterol 2025; 31(21): 105753

"Honored to collaborate with your esteemed magazine. The editorial team's professionalism is admirable, providing precise suggestions ..." [Read more]

"Honored to collaborate with your esteemed magazine. The editorial team's professionalism is admirable, providing precise suggestions on structure, language, and thematic refinement, showcasing exceptional expertise. Communication was efficient and considerate, blending respect for author intent with professional insights. Proud to publish in your journal and sincerely thankful. Looking forward to future collaborations. " [Collapse]

Qi GX, Zhao RX, Gao C, Ma ZY, Wang S, Xu J. Recent advances and challenges in colorectal cancer: From molecular research to treatment. World J Gastroenterol 2025; 31(21): 106964

"I don't have any problems, I will continue to submit, I hope that the journal will get better and better, the impact factor will be ..." [Read more]

"I don't have any problems, I will continue to submit, I hope that the journal will get better and better, the impact factor will be higher and higher, and more excellent articles can be published for readers to read, which is thought-provoking. Finally, I would like to thank the magazine for your trust. " [Collapse]

Sun M, Yu J, Zhou JW, Ye M, Ye F, Ding M. Can ChatGPT and DeepSeek help cancer patients: A comparative study of artificial intelligence models in clinical decision support. Artif Intell Cancer 2025; 6(1): 106356

"I am thoroughly impressed with this submission system! The platform is incredibly intuitive and user-friendly, making the entire ..." [Read more]

"I am thoroughly impressed with this submission system! The platform is incredibly intuitive and user-friendly, making the entire process seamless. Most notably, the editorial team operates with outstanding efficiency—their rapid response times, clear communication, and swift handling of manuscripts significantly reduce waiting periods. Such professionalism not only accelerates the review cycle but also makes submitting research a genuinely positive experience. Kudos to the editors for their exceptional dedication and speed! " [Collapse]

Han ZQ, Wen LN. Microbiota geography in the colorectal carcinoma microenvironment: A spatiotemporal atlas of colonic mucosal microbial niche reconstruction. World J Gastroenterol 2025; 31(21): 106057

"I wish to express my sincere gratitude to World Journal of Gastroenterology for publishing our research titled Electroacupuncture ..." [Read more]

"I wish to express my sincere gratitude to World Journal of Gastroenterology for publishing our research titled Electroacupuncture at ST36 ameliorates gastric dysmotility in rats with diabetic gastroparesis via the nucleus tractus solitarius-vagal axis in this esteemed journal. As a peer-reviewed SCI journal with rigorous academic standards, World Journal of Gastroenterology provides an invaluable platform for disseminating cutting-edge medical research. I deeply appreciate the editorial team's professionalism and efficiency throughout the submission and review process. The constructive feedback from the anonymous reviewers significantly improved the quality of our manuscript. Their expertise and meticulous attention to detail exemplify the journal's commitment to scientific excellence. It is an honor to contribute to World Journal of Gastroenterology's mission of advancing medical knowledge, and I look forward to future collaborations with the journal " [Collapse]

Zhang Y, Tang YW, Zhou J, Wei YR, Peng YT, Yan Z, Yue ZH. Electroacupuncture at ST36 ameliorates gastric dysmotility in rats with diabetic gastroparesis via the nucleus tractus solitarius-vagal axis. World J Gastroenterol 2025; 31(21): 107395

"Throughout the publication process—from submission and revision to acceptance and final proofreading—we have greatly benefited from ..." [Read more]

"Throughout the publication process—from submission and revision to acceptance and final proofreading—we have greatly benefited from the reviewers' professionalism and rigorous standards, which significantly improved our manuscript's quality. We particularly appreciate your editorial team's assistance and meticulous attention to detail, from textual refinements to figure arrangement. Finally，We sincerely thank the editors and reviewers for their time and valuable contributions to our manuscript. " [Collapse]

Zhu M, Tang MM, Zhou RH. Refractory ventricular fibrillation caused by coronary insufficiency after Bentall procedure: A case report. World J Clin Cases 2025; 13(23): 106886

"The peer review process was instrumental in improving the quality of our manuscript. The reviewers identified several misconceptions ..." [Read more]

"The peer review process was instrumental in improving the quality of our manuscript. The reviewers identified several misconceptions and areas that required clarification or deeper analysis. Their feedback was thorough, fair, and highly constructive, prompting us to revisit key points, refine our interpretations, and enhance the overall scientific rigor and clarity of the manuscript. We are grateful for the time and expertise invested by the reviewers, as their input significantly strengthened our work and ensured it met the journal’s standards. This experience highlights the value of a well-executed peer review in the advancement of scholarly communication. " [Collapse]

Vogli S, Papadakos SP, Argyrou A, Schizas D. Expanding the role of endoscopic resection in esophageal gastrointestinal stromal tumors: Insights and challenges. World J Gastroenterol 2025; 31(20): 106441

"Thank you very much for your kind support, and for the highly professional work of the editors and reviewers. I truly appreciate the ..." [Read more]

"Thank you very much for your kind support, and for the highly professional work of the editors and reviewers. I truly appreciate the reviewers’ insightful comments and thoughtful suggestions. The corrections and editing were meticulous and greatly improved the manuscript. Overall, the process was smooth, efficient, and of outstanding quality. " [Collapse]

Chatpermporn K, Chongpison Y, Ngoenmak T, Treepongkaruna S, Sintusek P. Validity and reliability of the Thai “Rome IV diagnostic questionnaires” for functional gastrointestinal disorders in neonates and toddlers. World J Clin Cases 2025; 12(23): 105022

"The publication process of this manuscript in your esteemed journal was exceptionally satisfactory, providing an outstanding overall ..." [Read more]

"The publication process of this manuscript in your esteemed journal was exceptionally satisfactory, providing an outstanding overall experience. All parties involved - from peer reviewers to editorial staff - maintained the highest standards of professionalism, facilitating remarkably efficient correspondence. Particularly impressive were the exceptional efficiency and short time-to-publication, for which I express my utmost satisfaction. " [Collapse]

Zhao F, Su CH, Hu SX, Feng L. Diplopia after middle meningeal artery embolization for chronic subdural hematoma: A case report. World J Clin Cases 2025; 12(23): 106329

"I am pleased to recount my experience with the World Journal of Clinical Cases. The peer review process was thorough, constructive, ..." [Read more]

"I am pleased to recount my experience with the World Journal of Clinical Cases. The peer review process was thorough, constructive, and timely, providing valuable feedback that significantly enhanced the quality of my manuscript. The editorial team was highly professional, ensuring a smooth and efficient publishing process. Overall, I am highly satisfied with the journal's commitment to maintaining high academic standards and supporting authors throughout the publication journey. " [Collapse]

Maity R, Rathna RB, Dhali A, Fernandes N, Biswas J, Kapoor GS, Dhali GK. Ulcerated benign jejunal gastrointestinal stromal tumor causing gastrointestinal bleeding: A case report. World J Clin Cases 2025; 12(23): 106140

"Everything was excellent. The editorial office services and prompt response to requests were enthusiastic. Also, the peer review ..." [Read more]

"Everything was excellent. The editorial office services and prompt response to requests were enthusiastic. Also, the peer review process could be characterized by great satisfaction. Thank you very much for your cooperation. I am looking forward to continuing this scientific activity. I hope to continue with the best impressions. Best regards from Thessaloniki, Greece. " [Collapse]

Mouratidou C, Pavlidis ET, Katsanos G, Kotoulas SC, Tsoulfas G, Mouloudi E, Taitzoglou IA, Galanis IN, Pavlidis TE. Off-label use of treprostinil in adult patients in clinical cases. World J Clin Cases 2025; 13(23): 107279

"Thank you to the editor and reviewers for your constructive suggestions, which have helped improve the quality of the paper and ..." [Read more]

"Thank you to the editor and reviewers for your constructive suggestions, which have helped improve the quality of the paper and maintain academic standards. Thanks to your efforts, this work has become more complete. You have made significant contributions to the research. We express our highest respect for your rigorous working attitude and professional working ability. " [Collapse]

Ao C, Hu S, Zhan L. Exercise rehabilitation based on medical care-family integration in older patients with chronic heart failure and psychological problems. World J Psychiatry 2025; 15(6): 105855

"This is our second publication via BPG publication.Very much satisfied with BPG publishing. Will submit more articles in future as ..." [Read more]

"This is our second publication via BPG publication.Very much satisfied with BPG publishing. Will submit more articles in future as well, and will also urge my collueges to publish in BPG journals. Thank you. The submission and peee review is very simple and user friendly. Very high quality and in depth peer review report. " [Collapse]

Roy M, Bhikshavarthi Math SA, Das D, Dwidmuthe S. Broken bioabsorbable tibial interference screw post-arthroscopic anterior cruciate ligament reconstruction: A case report. World J Clin Cases 2025; 12(23): 105003

"I would like to sincerely thank the editorial team and reviewers for their professionalism and efficiency throughout the publication ..." [Read more]

"I would like to sincerely thank the editorial team and reviewers for their professionalism and efficiency throughout the publication process. Their clear communication and prompt feedback made the experience smooth and rewarding. I appreciate the opportunity to share my work and contribute to the scholarly dialogue in the field. Thank you. " [Collapse]

Kupietzky A, Bar-Moshe Y, Lavie N, Drayer Lichtman M, Dover R, Juster EY, Maden A, Mazeh H, Mizrahi I. Leaving no stone unturned: Impact of appendicolith and characteristics on long-term recurrence after non-operative appendicitis. World J Clin Cases 2025; 12(23): 106532

"It has been an incredible experience to publish in the World Journal of Gastroenterology especially for addressing a very interesting ..." [Read more]

"It has been an incredible experience to publish in the World Journal of Gastroenterology especially for addressing a very interesting and timely topic. We hope our contribution can cause an impact in the Gastroenterology community and more treatments for hepatocellular carcinoma can be created and better tailored for our patients. " [Collapse]

Sierra L, Abu-Hammour MN, Chatterjee A, Simons-Linares CR. Obesity paradox role in the immunosuppressive treatment of hepatocellular carcinoma. World J Gastroenterol 2025; 31(19): 105617

"We are not only thankful to the journal for providing us with a valuable platform for academic exchanges, where sparks of ideas can ..." [Read more]

"We are not only thankful to the journal for providing us with a valuable platform for academic exchanges, where sparks of ideas can collide and shine, but also value this rare opportunity, which is like a lighthouse illuminating the path of our research. We are looking forward to continue sharing the fruit of our research in this widely respected journal, and to draw a picture of knowledge with scholars all over the world. " [Collapse]

Deng YF, Zhao YQ, Wang L, Cui XS. Understanding the risk factors of hemagglutinase-associated hypofibrinogenemia can improve the prognosis of patients. World J Gastrointest Surg 2025; 17(6): 101206

"I am very satisfied with this submission. After multiple revisions, it was finally published online. After going through the peer ..." [Read more]

"I am very satisfied with this submission. After multiple revisions, it was finally published online. After going through the peer review by experts, it was fair and impartial. Through the revisions, I also learned about many of my shortcomings. Moreover, the editorial department of the magazine was very patient in communicating with me, which helped me learn a lot. Thank you. " [Collapse]

Wang Q, Yan XQ, Ma XM, Yan R, Wang ZH, Ma YJ, Wang HB. Multimodal analgesia in cardiac surgery: Impact on postoperative medication consumption and cognitive function. World J Cardiol 2025; 17(5): 103168

18788 items Read more >>

Article Quality Tracking-Peer-Review

"The healthy volunteers and the case groups should also be checked for conditions that would alter gut microbime including bacterial ..." [Read more]

"The healthy volunteers and the case groups should also be checked for conditions that would alter gut microbime including bacterial overgrowth syndrome. This is a large entity that consists of GI motility disorders, anatomical anomalies and so on. There are large body of evidence regarding the role of bacterial overgrowth syndrome in progression of chronic liver disease. The enterance of bacterial endotoxins through portal vein as a result of leaky gut is another important issue that should be addressed in the methodology." [Collapse]

Ma C, Yang J, Fu XN, Luo JY, Liu P, Zeng XL, Li XY, Zhang SL, Zheng S. Microbial characteristics of gut microbiome dysbiosis in patients with chronic liver disease. World J Hepatol 2025; 17(5): 106124

"A well desined study in the field of biliary stricture management. Further researches are needed to identify if stent placemnet would ..." [Read more]

"A well desined study in the field of biliary stricture management. Further researches are needed to identify if stent placemnet would have added value to biliary dilation alone. It seemes that percutaneous approach might be more feasible in proximal strictures than the distal ones. Moreover, in ishemia induced strictures, timely diagnosis and appropriate intervention might be a key preventive management." [Collapse]

Trifonov S, Kovalenko Y, Gurmikov B, Varava A, Vodeiko V, Pakhtushkin E, Vishnevsky V, Zharikov Y. Reconstructive surgery and percutaneous balloon dilation for the treatment of benign biliary strictures: A retrospective study. World J Hepatol 2025; 17(5): 104646

"Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is an effective and minimally invasive alternative treatment for gastric outlet ..." [Read more]

"Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is an effective and minimally invasive alternative treatment for gastric outlet obstruction. Compared with conventional treatments such as duodenal stent placement and surgical gastrojejunostomy, EUS-GE has comparable technical and clinical success rates, with the advantages of longer patency, fewer adverse events, and lower reintervention rates. This technique is applicable not only to malignant obstruction, but also to complex pathologies such as benign lesions and afferent loop syndrome, and is a promising treatment that allows early recovery and resumption of oral intake, which is crucial for oncological patients. This review explained this point." [Collapse]

Karagyozov PI, Kavrakov D, Shumka N. Endoscopic ultrasound-guided gastroenterostomy: The new standard treatment of gastric outlet obstruction. Artif Intell Gastrointest Endosc 2025; 6(2): 106600

"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Zhong XY, Liang ZJ, Lan ML, Xu XG, Yuan L, Zeng JX. Acinar cystic transformation of the pancreas: A rare case report. World J Clin Cases 2025; 13(23): 107096

"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Cicek E, Karatepe YK, Kantarcı TR, Sahin TT. Demanding sleeve gastrectomy procedure in a patient with severe intraabdominal adhesions: A case report and review of the literature. World J Clin Cases 2025; 12(23): 104807

"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Zhao KF, Xie CB, Wu Y. Prediction of the efficacy of first transarterial chemoembolization for advanced hepatocellular carcinoma via a clinical-radiomics model. World J Clin Cases 2025; 12(23): 101742

"The article provides a valuable contribution to the field by offering a comprehensive and balanced review of the immunomodulatory ..." [Read more]

"The article provides a valuable contribution to the field by offering a comprehensive and balanced review of the immunomodulatory effects of CQ and HCQ in autoimmune diseases. While it acknowledges the existence of certain problems, such as inter-individual variability in therapeutic response, it proposes potential solutions through further research and the development of personalized treatment approaches. It a useful resource for healthcare professionals and researchers involved in the management of autoimmune diseases. Ethics: The article does not directly provide an ethical approval form; however, it is a mini-review rather than an experimental study involving human or animal subjects. Methods: The article provides a comprehensive review of the immunomodulatory effects of chloroquine (CQ) and hydroxychloroquine (HCQ) in autoimmune diseases. It discusses the mechanisms of action, clinical applications, and safety considerations based on existing literature. As it is a review article, it does not present original experimental data. The methods used to compile and analyze the literature are not explicitly detailed, but the article follows a logical structure and cites relevant sources. The approach is reproducible by fellow researchers interested in conducting a similar literature review. Results: The results presented are based on existing research and clinical trials. The article summarizes the findings of previous studies, indicating that CQ and HCQ have immunomodulatory effects and clinical benefits in various autoimmune diseases. While the results are not original experimental data, they are true and authentic summaries of published research. The theory or hypothesis of the immunomodulatory effects of CQ and HCQ is well-validated by the cited literature. Figures and tables: The article includes a few figures and tables to illustrate key points. Figure 1 depicts the immunomodulatory effects of CQ and HCQ on various immune cells, and Figure 2 summarizes the clinical applications across autoimmune diseases. Table 1 lists clinically relevant drug interactions with CQ and HCQ. These figures and tables are well-constructed, annotated, and helpful in conveying the information clearly. Biostatistics: As the article is a review and does not present original research data, it does not include biostatistical data or line charts with data. Therefore, this aspect is not applicable to the evaluation. References: The article cites numerous references that are scientifically and reasonably important in the field of autoimmune diseases and related to the immunomodulatory effects of CQ and HCQ. The references are recent and cover a broad range of relevant topics, indicating a thorough literature search. The author does not appear to self-cite excessively, omit critical references, or miscite sources. Language: The language in the article is correct, clear, and concise. It effectively conveys the information about the immunomodulatory effects of CQ and HCQ in autoimmune diseases. The article has no apparent grammatical or spelling mistakes. Caveats or drawbacks: The main caveats or drawbacks of the article are that it is a review and does not present original experimental data. Therefore, it does not provide new insights or results beyond what is already known from previous studies. Additionally, the article does not address potential biases in the cited literature or fully discuss limitations of the existing research on CQ and HCQ. The long-term side effects and the need for personalized treatment approaches are highlighted as important considerations but not fully explored. " [Collapse]

Al-Hamadani M, Darweesh M, Mohammadi S, Al-Harrasi A. Chloroquine and hydroxychloroquine: Immunomodulatory effects in autoimmune diseases. World J Biol Chem 2025; 16(2): 107042

"Traditional Chinese medicine (TCM) is used to treat a vast number of medical conditions with very satisfactory results. One of these ..." [Read more]

"Traditional Chinese medicine (TCM) is used to treat a vast number of medical conditions with very satisfactory results. One of these therapeutic fields is chronic atrophic gastritis, in which the fungus Hericium erinaceus has been shown to improve clinical manifestations and histological findings. Its antimicrobial action against Helicobacter pylori and its anticancer action against gastric cancer is also interesting. It is time for universities, large pharmaceutical companies, and health authorities in various countries to take seriously the clinical and laboratory results of Complementary and Alternative Treatments for multiple diseases and to allocate teaching hours and financial funding to investigate the combination of CAM with modern medicine in treating a bunch of benign and malignant conditions of the digestive system. Ultimately, doctors in developed countries should reconsider their skepticism about the efficacy of CAM, particularly traditional Chinese medicine. " [Collapse]

Pellegrino R, Gravina AG. Potential of traditional Chinese medicine in gastrointestinal disorders: Hericium erinaceus in chronic atrophic gastritis. World J Gastroenterol 2025; 31(20): 106615

"The occurrence of acute kidney injury in liver cirrhosis patients is associated with poor short-term mortality. This review is devoted ..." [Read more]

"The occurrence of acute kidney injury in liver cirrhosis patients is associated with poor short-term mortality. This review is devoted to the latest concepts in the field of pathophysiology, diagnosis and treatment of acute kidney injury in liver cirrhosis patients. This is a well-structured review based on the current understanding of this actual issue." [Collapse]

Malakar S, Rungta S, Samanta A, Shamsul Hoda U, Mishra P, Pande G, Roy A, Giri S, Rai P, Mohindra S, Ghoshal UC. Understanding acute kidney injury in cirrhosis: Current perspective. World J Hepatol 2025; 17(5): 104724

"The article addresses the timely and pertinent subject of the potential of PRF in clinical applications related to wound healing and ..." [Read more]

"The article addresses the timely and pertinent subject of the potential of PRF in clinical applications related to wound healing and the immune response. The language used is clear and accessible, making complex biological concepts understandable to a wide readership. As an editorial, it effectively summarises key points without unnecessary elaboration, respecting the format's purpose. While the editorial provides a succinct overview of the potential benefits of PRF in wound healing and immune response, incorporating recent research findings and a more detailed exploration of the underlying mechanisms would enhance it further." [Collapse]

Mohammadi S. Innate immunity and wound repair: The platelet-rich fibrin advantage. World J Biol Chem 2025; 16(2): 107195

"This article addresses the important and timely topic of the immunomodulatory effects of chloroquine and hydroxychloroquine in ..." [Read more]

"This article addresses the important and timely topic of the immunomodulatory effects of chloroquine and hydroxychloroquine in autoimmune diseases. This topic remains highly relevant for clinical and research audiences alike. The review provides a comprehensive overview of various autoimmune conditions and the mechanisms through which these drugs exert their effects, offering readers a valuable summary of the current state of knowledge in this area. The article is organised coherently, progressing logically from drug mechanisms to clinical applications, which makes it easy for readers to understand. However, while it discusses the immunomodulatory effects of these drugs, the article lacks a critical analysis of the results from the cited studies. There is little discussion of the strength of the evidence, the limitations of the studies, or the quality of the data presented. Furthermore, while the article cites relevant literature, it does not include the most recent studies, particularly those published within the last year. Additionally, there is little discussion of conflicting evidence or ongoing debates in the field. While the article briefly mentions the potential side effects of chloroquine and hydroxychloroquine, it does not address the controversies surrounding their use, such as the debate over their efficacy and safety profiles in different patient populations. Including a more in-depth discussion of the limitations, controversies and areas of uncertainty surrounding the use of these drugs in autoimmune diseases would provide a more balanced perspective." [Collapse]

Al-Hamadani M, Darweesh M, Mohammadi S, Al-Harrasi A. Chloroquine and hydroxychloroquine: Immunomodulatory effects in autoimmune diseases. World J Biol Chem 2025; 16(2): 107042

"This mini-review is concise and well organised, providing a comprehensive overview of the topic. It effectively summarises the existing ..." [Read more]

"This mini-review is concise and well organised, providing a comprehensive overview of the topic. It effectively summarises the existing challenges and highlights the potential of stem cell therapy in Parkinson’s disease. To further enrich the article, it would be beneficial to include a comparative table summarising the different types of stem cells (e.g. ESCs, iPSCs and MSCs) and their respective advantages and disadvantages. Additionally, expanding upon novel technological advancements (e.g. CRISPR, organoids or biomaterials) would provide a forward-looking perspective that aligns with current research trends. Overall, this article meets BPG's quality standards and is a valuable contribution to the field of neurodegenerative medicine. However, the existing figures are relatively few, lack quantitative detail, and are very simple. For instance, it would be highly beneficial to include a comparative table summarising the different stem cell types, their sources, differentiation capacities, and clinical readiness. I would recommend adding at least one comprehensive table summarising and comparing therapeutic options, mechanisms or clinical trial data." [Collapse]

Mokhtari YG, Varnava I, Kyrgiannis K, Ampatsidou V, Giakoumettis D. Stem cell therapy for Parkinson’s disease: A new hope for neural regeneration. World J Biol Chem 2025; 16(2): 106850

"This is very interesting paper. I ask some questions for author. In the past, surgical necrosectomy was performed for necrotizing ..." [Read more]

"This is very interesting paper. I ask some questions for author. In the past, surgical necrosectomy was performed for necrotizing pancreatitis, but this had a high incidence of complications. In recent years, endoscopic drainage has become more effective, but should it be performed after waiting four weeks until encapsulated necrosis (WON) occurs, or if MOF or infection is difficult to control, should it be ？" [Collapse]

Zeng Y, Zhang JW, Yang J. Endoscopic management of infected necrotizing pancreatitis: Advancing through standardization. World J Gastroenterol 2025; 31(20): 107451

"The article is devoted to the search for new markers for the diagnosis of AMA-negative forms of primary biliary cholangitis (PBC), ..." [Read more]

"The article is devoted to the search for new markers for the diagnosis of AMA-negative forms of primary biliary cholangitis (PBC), which is an important problem in hepatology. The authors of the study posit that the antibodies to RPL30 that were identified may serve as such a marker. The rationale behind the authors' decision to focus on the RPL30 protein, a constituent of the 60S ribosome subunit involved in protein synthesis, remains ambiguous. The impaired protein synthesis function of the liver in PBC occurs when a patient develops signs of progressive cholestasis involving hepatocytes, both in AMA-positive and AMA-negative patients. At the same time, in the early stages of PBC, cholangiocytes lining the small (intralobular, interlobular) bile ducts are primarily damaged. Therefore, the authors' rationale for determining antibodies to RPL30 remains ambiguous. Besidesr, the article does not provide a comprehensive analysis of the relationship between the detection of antibodies against RPL30 and the data on histological signs that confirm the presence of PBC. The results obtained by the authors on the diagnostic value of antimitochondrial antibodies for the diagnosis of PBC are questionable.. The objective of the present study is to identify novel biomarkers that can facilitate the diagnosis of AMA-negative forms of PBC, a significant area of research in the field of hepatology. However, the motives behind this study remain unclear. What was the prerequisite for the study of antibodies to ribosomal protein L30? What role can ribosomal protein L30 play in the pathogenesis of PBC?" [Collapse]

Zeng ZY, Huang ZX, Wang YR, Xie LK, Lin YP, Liang Y, Liu ZY, Li DL, Zhang XY. Anti-RPL30 as a novel biomarker for enhanced diagnosis of autoantibody-negative primary biliary cholangitis. World J Gastroenterol 2025; 31(20): 104891

"Neuroendocrine tumors of the rectum are a relatively rare malignancy that is often diagnosed during colonoscopy. In recent years, ..." [Read more]

"Neuroendocrine tumors of the rectum are a relatively rare malignancy that is often diagnosed during colonoscopy. In recent years, its incidence has been observed to be increasing. These small tumors can be removed endoscopically using modified endoscopic submucosal resection (mEMR) or endoscopic submucosal resection. In the annotated review article, the authors discuss the indications, methods, risks, and difficulties of their endoscopic removal and propose a therapeutic algorithm to assist in making correct treatment decisions. An essential part of treating these tumors is the accurate evaluation of their endoscopic characteristics and the demonstration by means of imaging methods of any lymph node metastases or distant metastases. Also, an essential part of the correct treatment of these tumors, which is usually neglected in everyday clinical practice, is the avoidance of taking a simple biopsy. EMR with submucosal dilatation should be preferred. Patient follow-up is an essential part of proper patient management. Finally, managing these patients by a team of specialists, which includes a gastroenterologist, oncologist, and pathologist with substantial experience in diagnosing and treating these neoplasms, represents an essential element regarding the best possible management of the patients. This article contributes substantially to enriching the knowledge of gastroenterologists and oncologists about diagnosing and managing rectal neuroendocrine tumors. " [Collapse]

Liu JN, Chen H, Fang N. Current status of endoscopic resection for small rectal neuroendocrine tumors. World J Gastroenterol 2025; 31(19): 106814

"This is a well-written and presented rarely case report about Chronic abdominal pain caused by foreign bodies in the appendix .This ..." [Read more]

"This is a well-written and presented rarely case report about Chronic abdominal pain caused by foreign bodies in the appendix .This manuscript gives additional new knowledge to the existing literature. This interesting and rare case report has certain guiding significance for clinicians.I think that this manuscript is worth to publication." [Collapse]

Huang T, Li SK, Wang W, Zhang R. Chronic abdominal pain caused by foreign bodies in the appendix: A case report. World J Gastrointest Surg 2025; 17(5): 105423

"This is very interesting paper. In the past, obesity was said to be bad for treatment, but the current data shows that a BMI of ..." [Read more]

"This is very interesting paper. In the past, obesity was said to be bad for treatment, but the current data shows that a BMI of >35mg/dl is said to be associated with a good prognosis. lenvatinib and camrelizumab were good effect for obesity patient with HCC　and 　have not yet been observed with more commonly used immunotherapy treatments for hepatocellular carcinoma, such as nivolumab, pembrolizumab, or bevacizumab. In the past, obesity was said to be bad for treatment, but the current data shows that a BMI of >35mg/dl is said to be associated with a good prognosis. " [Collapse]

Sierra L, Abu-Hammour MN, Chatterjee A, Simons-Linares CR. Obesity paradox role in the immunosuppressive treatment of hepatocellular carcinoma. World J Gastroenterol 2025; 31(19): 105617

"The authors claimed that helicobacter pylori infection could promote the progression of gastric cancer by regulating the expression ..." [Read more]

"The authors claimed that helicobacter pylori infection could promote the progression of gastric cancer by regulating the expression of DMBT1, however, The “tumor progression” involves multiple aspects. In this study, it was mainly investigated through in vitro “scratch, and Transwell assays”. It is too simple. Evidently, these approaches are insufficient to comprehensively address this complex issue. Another big concern is that, cancer is a complex system, not genetic disease. In fact, merely exploring the occurrence and development of cancer from the perspective of mutation/molecules pathway is insufficient to address the complex problems such as recurrence and resistance that arise in clinical practice." [Collapse]

Zhou X, Wang LQ, Song S, Xu M, Li CP. Helicobacter pylori infection promotes the progression of gastric cancer by regulating the expression of DMBT1. World J Clin Oncol 2025; 16(5): 105322

"This study proposed that “HOXC6 may influence the cellular functions of BLCA by regulating the expression of the target gene TIMELESS,” ..." [Read more]

"This study proposed that “HOXC6 may influence the cellular functions of BLCA by regulating the expression of the target gene TIMELESS,” yet no direct evidence was provided to substantiate this claim. Another major concern is that cancer represents a complex system rather than merely a genetic disease. Indeed, focusing solely on mutations and molecular mechanisms to explore the occurrence and progression of cancer is insufficient to address the intricate challenges, such as recurrence and resistance, encountered in clinical practice. Overall, this research is seriously lacking both in terms of its content and significance" [Collapse]

Lu DJ, Wang HR, Xu YS, Huang HB, Zhong QG, Luo YN, Qi JF, Wu HC, Pei JY, Zhang K, Xu CX, Wang TX, Zhang W, Zhou YH, Huang ZG, Wang FB. Homeobox C6 plays an oncogenic role in bladder cancer. World J Clin Oncol 2025; 16(5): 103830

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Peer-Reviewers and Manuscript Statistics

Editorial board members: 2266

Peer-reviewers: 31439

Manuscripts received today: 9

Manuscript reviews today: 8

Unhandled manuscripts today: 172

Active peer-reviewers today: 466

Reviewer acceptance today: 13

Reviewer refusals today: 12

Total accepted manuscripts: 36335

Total rejected manuscripts: 41925

Total peer-reviewers: 4239222

Total submissions: 34517