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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
2
Role of the normal gut microbiota  
Sai Manasa Jandhyala, Rupjyoti Talukdar, Chivkula Subramanyam, Harish Vuyyuru, Mitnala Sasikala, D Nageshwar Reddy 
World J Gastroenterol 21(29):8787-8803. Published online Aug 7, 2015. doi: 10.3748/wjg.v21.i29.8787
3
I.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life  
Vicente Lorenzo-Zúñiga, Elba Llop, Cristina Suárez, Beatriz Álvarez, Luis Abreu, Jordi Espadaler, Jordi Serra 
World J Gastroenterol 20(26):8709-8716. Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8709
4
Hemorrhoids: From basic pathophysiology to clinical management  
Varut Lohsiriwat 
World J Gastroenterol 18(17):2009-2017. Published online May 7, 2012. doi: 10.3748/wjg.v18.i17.2009
5
Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: A review  
Kuan-Yin Lin, Guan-Jhou Chen, Yu-Lin Lee, Yi-Chia Huang, Aristine Cheng, Hsin-Yun Sun, Sui-Yuan Chang, Chun-Eng Liu, Chien-Ching Hung 
World J Gastroenterol 23(20):3589-3606. Published online May 28, 2017. doi: 10.3748/wjg.v23.i20.3589
6
Pathogenesis of alcoholic liver disease: Role of oxidative metabolism  
Elisabetta Ceni, Tommaso Mello, Andrea Galli 
World J Gastroenterol 20(47):17756-17772. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17756
7
Comprehensive review of diagnostic modalities for early chronic pancreatitis  
Qi-Chao Ge, Christoph F Dietrich, Manoop S Bhutani, Bao-Zhen Zhang, Yue Zhang, Yi-Dan Wang, Jing-Jing Zhang, Yu-Fan Wu, Si-Yu Sun, Jin-Tao Guo 
World J Gastroenterol 27(27):4342-4357. Published online Jul 21, 2021. doi: 10.3748/wjg.v27.i27.4342
8
Cloning and expression of SLC10A4, a putative organic anion transport protein  
Patrick L Splinter, Konstantinos N Lazaridis, Paul A Dawson, Nicholas F LaRusso 
World J Gastroenterol 12(42):6797-6805. Published online Nov 14, 2006. doi: 10.3748/wjg.v12.i42.6797
9
10
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes  
Andrew McGuigan, Paul Kelly, Richard C Turkington, Claire Jones, Helen G Coleman, R Stephen McCain 
World J Gastroenterol 24(43):4846-4861. Published online Nov 21, 2018. doi: 10.3748/wjg.v24.i43.4846
11
Interleukin-12 and Th1 immune response in Crohn’s disease: Pathogenetic relevance and therapeutic inplication  
Ilaria Peluso, Francesco Pallone, Giovanni Monteleone 
World J Gastroenterol 12(35):5606-5610. Published online Sep 21, 2006. doi: 10.3748/wjg.v12.i35.5606
12
Role of the endothelium in inflammatory bowel diseases  
Walter E Cromer, J Michael Mathis, Daniel N Granger, Ganta V Chaitanya, J Steven Alexander 
World J Gastroenterol 17(5):578-593. Published online Feb 7, 2011. doi: 10.3748/wjg.v17.i5.578
13
Technical skills and training of upper gastrointestinal endoscopy for new beginners  
Seung-Hwa Lee, Young-Kyu Park, Sung-Min Cho, Joon-Koo Kang, Duck-Joo Lee 
World J Gastroenterol 21(3):759-785. Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.759
14
Anemia and iron deficiency in gastrointestinal and liver conditions  
Jürgen Stein, Susan Connor, Garth Virgin, David Eng Hui Ong, Lisandro Pereyra 
World J Gastroenterol 22(35):7908-7925. Published online Sep 21, 2016. doi: 10.3748/wjg.v22.i35.7908
15
16
Brain-gut-microbiota axis in Parkinson's disease  
Agata Mulak, Bruno Bonaz 
World J Gastroenterol 21(37):10609-10620. Published online Oct 7, 2015. doi: 10.3748/wjg.v21.i37.10609
17
Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients!  
Anamaria Cozma-Petruţ, Felicia Loghin, Doina Miere, Dan Lucian Dumitraşcu 
World J Gastroenterol 23(21):3771-3783. Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3771
18
19
Systematic review and meta-analysis of Saccharomyces boulardii in adult patients  
Lynne V McFarland 
World J Gastroenterol 16(18):2202-2222. Published online May 14, 2010. doi: 10.3748/wjg.v16.i18.2202
20
Celiac disease: Prevalence, diagnosis, pathogenesis and treatment  
Naiyana Gujral, Hugh J Freeman, Alan BR Thomson 
World J Gastroenterol 18(42):6036-6059. Published online Nov 14, 2012. doi: 10.3748/wjg.v18.i42.6036
21
Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma  
Jun-Jie Xiong, Kiran Altaf, Muhammad A Javed, Wei Huang, Rajarshi Mukherjee, Gang Mai, Robert Sutton, Xu-Bao Liu, Wei-Ming Hu 
World J Gastroenterol 18(45):6657-6668. Published online Dec 7, 2012. doi: 10.3748/wjg.v18.i45.6657
22
Gut microbiota in autism and mood disorders  
Francesca Mangiola, Gianluca Ianiro, Francesco Franceschi, Stefano Fagiuoli, Giovanni Gasbarrini, Antonio Gasbarrini 
World J Gastroenterol 22(1):361-368. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.361
23
Exploring alternative treatments for Helicobacter pylori infection  
Guadalupe Ayala, Wendy Itzel Escobedo-Hinojosa, Carlos Felipe de la Cruz-Herrera, Irma Romero 
World J Gastroenterol 20(6):1450-1469. Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1450
24
Irritable bowel syndrome: Pathogenesis, diagnosis, treatment, and evidence-based medicine  
Lekha Saha 
World J Gastroenterol 20(22):6759-6773. Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.6759
25
Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer  
Jonathan Landy, Emma Ronde, Nick English, Sue K Clark, Ailsa L Hart, Stella C Knight, Paul J Ciclitira, Hafid Omar Al-Hassi 
World J Gastroenterol 22(11):3117-3126. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3117
26
27
Benign gallbladder diseases: Imaging techniques and tips for differentiating with malignant gallbladder diseases  
Mi Hye Yu, Young Jun Kim, Hee Sun Park, Sung Il Jung 
World J Gastroenterol 26(22):2967-2986. Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.2967
28
Potential beneficial effects of butyrate in intestinal and extraintestinal diseases  
Roberto Berni Canani, Margherita Di Costanzo, Ludovica Leone, Monica Pedata, Rosaria Meli, Antonio Calignano 
World J Gastroenterol 17(12):1519-1528. Published online Mar 28, 2011. doi: 10.3748/wjg.v17.i12.1519
29
Immunopathology of inflammatory bowel disease  
Kori L Wallace, Li-Bo Zheng, Yoshitake Kanazawa, David Q Shih 
World J Gastroenterol 20(1):6-21. Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.6
30
Beyond the stomach: An updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment  
Traci L Testerman, James Morris 
World J Gastroenterol 20(36):12781-12808. Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.12781
31
32
Gastroenteric tube feeding: Techniques, problems and solutions  
Irina Blumenstein, Yogesh M Shastri, Jürgen Stein 
World J Gastroenterol 20(26):8505-8524. Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8505
33
Seroprevalence of celiac disease among United Arab Emirates healthy adult nationals: A gender disparity  
Yousif A Abu-Zeid, Waheeba S Jasem, Benjamin Lebwohl, Peter H Green, Gehad ElGhazali 
World J Gastroenterol 20(42):15830-15836. Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15830
34
Gut microbiota imbalance and colorectal cancer  
Johan Gagnière, Jennifer Raisch, Julie Veziant, Nicolas Barnich, Richard Bonnet, Emmanuel Buc, Marie-Agnès Bringer, Denis Pezet, Mathilde Bonnet 
World J Gastroenterol 22(2):501-518. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.501
35
Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C  
Bogna Świątek-Kościelna, Ewelina Kałużna, Ewa Strauss, Jerzy Nowak, Iwona Bereszyńska, Ewelina Gowin, Jacek Wysocki, Jolanta Rembowska, Dominika Barcińska, Iwona Mozer-Lisewska, Danuta Januszkiewicz-Lewandowska 
World J Gastroenterol 23(21):3815-3824. Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3815
36
Small intestinal bacterial overgrowth syndrome  
Jan Bures, Jiri Cyrany, Darina Kohoutova, Miroslav Förstl, Stanislav Rejchrt, Jaroslav Kvetina, Viktor Vorisek, Marcela Kopacova 
World J Gastroenterol 16(24):2978-2990. Published online Jun 28, 2010. doi: 10.3748/wjg.v16.i24.2978
37
Endoscopic Kyoto classification of Helicobacter pylori infection and gastric cancer risk diagnosis  
Osamu Toyoshima, Toshihiro Nishizawa, Kazuhiko Koike 
World J Gastroenterol 26(5):466-477. Published online Feb 7, 2020. doi: 10.3748/wjg.v26.i5.466
38
Treatment options for alcoholic and non-alcoholic fatty liver disease: A review  
Sukhpreet Singh, Natalia A Osna, Kusum K Kharbanda 
World J Gastroenterol 23(36):6549-6570. Published online Sep 28, 2017. doi: 10.3748/wjg.v23.i36.6549
39
Nonalcoholic fatty liver disease: Evolving paradigms  
Amedeo Lonardo, Fabio Nascimbeni, Mauro Maurantonio, Alessandra Marrazzo, Luca Rinaldi, Luigi Elio Adinolfi 
World J Gastroenterol 23(36):6571-6592. Published online Sep 28, 2017. doi: 10.3748/wjg.v23.i36.6571
40
New trends in molecular and cellular biomarker discovery for colorectal cancer  
Parisa Aghagolzadeh, Ramin Radpour 
World J Gastroenterol 22(25):5678-5693. Published online Jul 7, 2016. doi: 10.3748/wjg.v22.i25.5678
41
Gastrointestinal radiation injury: Symptoms, risk factors and mechanisms  
Abobakr K Shadad, Frank J Sullivan, Joseph D Martin, Laurence J Egan 
World J Gastroenterol 19(2):185-198. Published online Jan 14, 2013. doi: 10.3748/wjg.v19.i2.185
42
Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries  
María José Domper Arnal, Ángel Ferrández Arenas, Ángel Lanas Arbeloa 
World J Gastroenterol 21(26):7933-7943. Published online Jul 14, 2015. doi: 10.3748/wjg.v21.i26.7933
43
Pathogenesis and clinical management of Helicobacter pylori gastric infection  
Breno Bittencourt de Brito, Filipe Antônio França da Silva, Aline Silva Soares, Vinícius Afonso Pereira, Maria Luísa Cordeiro Santos, Mariana Miranda Sampaio, Pedro Henrique Moreira Neves, Fabrício Freire de Melo 
World J Gastroenterol 25(37):5578-5589. Published online Oct 7, 2019. doi: 10.3748/wjg.v25.i37.5578
44
Stopping or reducing dietary fiber intake reduces constipation and its associated symptoms  
Kok-Sun Ho, Charmaine You Mei Tan, Muhd Ashik Mohd Daud, Francis Seow-Choen 
World J Gastroenterol 18(33):4593-4596. Published online Sep 7, 2012. doi: 10.3748/wjg.v18.i33.4593
45
Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis  
Derrick D Eichele, Kusum K Kharbanda 
World J Gastroenterol 23(33):6016-6029. Published online Sep 7, 2017. doi: 10.3748/wjg.v23.i33.6016
46
Application of metagenomics in the human gut microbiome  
Wei-Lin Wang, Shao-Yan Xu, Zhi-Gang Ren, Liang Tao, Jian-Wen Jiang, Shu-Sen Zheng 
World J Gastroenterol 21(3):803-814. Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.803
47
48
Diet and nutritional factors in inflammatory bowel diseases  
Danuta Owczarek, Tomasz Rodacki, Renata Domagała-Rodacka, Dorota Cibor, Tomasz Mach 
World J Gastroenterol 22(3):895-905. Published online Jan 21, 2016. doi: 10.3748/wjg.v22.i3.895
49
New obesity classification criteria as a tool for bariatric surgery indication  
Antonino De Lorenzo, Laura Soldati, Francesca Sarlo, Menotti Calvani, Nicola Di Lorenzo, Laura Di Renzo 
World J Gastroenterol 22(2):681-703. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.681
50
Liver cancer stem cell markers: Progression and therapeutic implications  
Jing-Hui Sun, Qing Luo, Ling-Ling Liu, Guan-Bin Song 
World J Gastroenterol 22(13):3547-3557. Published online Apr 7, 2016. doi: 10.3748/wjg.v22.i13.3547