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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
I.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life  
Vicente Lorenzo-Zúñiga, Elba Llop, Cristina Suárez, Beatriz Álvarez, Luis Abreu, Jordi Espadaler, Jordi Serra 
World J Gastroenterol 20(26):8709-8716. Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8709
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3
Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: A review  
Kuan-Yin Lin, Guan-Jhou Chen, Yu-Lin Lee, Yi-Chia Huang, Aristine Cheng, Hsin-Yun Sun, Sui-Yuan Chang, Chun-Eng Liu, Chien-Ching Hung 
World J Gastroenterol 23(20):3589-3606. Published online May 28, 2017. doi: 10.3748/wjg.v23.i20.3589
4
Role of the normal gut microbiota  
Sai Manasa Jandhyala, Rupjyoti Talukdar, Chivkula Subramanyam, Harish Vuyyuru, Mitnala Sasikala, D Nageshwar Reddy 
World J Gastroenterol 21(29):8787-8803. Published online Aug 7, 2015. doi: 10.3748/wjg.v21.i29.8787
5
Hemorrhoids: From basic pathophysiology to clinical management  
Varut Lohsiriwat 
World J Gastroenterol 18(17):2009-2017. Published online May 7, 2012. doi: 10.3748/wjg.v18.i17.2009
6
Interleukin-12 and Th1 immune response in Crohn’s disease: Pathogenetic relevance and therapeutic inplication  
Ilaria Peluso, Francesco Pallone, Giovanni Monteleone 
World J Gastroenterol 12(35):5606-5610. Published online Sep 21, 2006. doi: 10.3748/wjg.v12.i35.5606
7
Pathogenesis of alcoholic liver disease: Role of oxidative metabolism  
Elisabetta Ceni, Tommaso Mello, Andrea Galli 
World J Gastroenterol 20(47):17756-17772. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17756
8
9
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes  
Andrew McGuigan, Paul Kelly, Richard C Turkington, Claire Jones, Helen G Coleman, R Stephen McCain 
World J Gastroenterol 24(43):4846-4861. Published online Nov 21, 2018. doi: 10.3748/wjg.v24.i43.4846
10
Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma  
Jun-Jie Xiong, Kiran Altaf, Muhammad A Javed, Wei Huang, Rajarshi Mukherjee, Gang Mai, Robert Sutton, Xu-Bao Liu, Wei-Ming Hu 
World J Gastroenterol 18(45):6657-6668. Published online Dec 7, 2012. doi: 10.3748/wjg.v18.i45.6657
11
Role of the endothelium in inflammatory bowel diseases  
Walter E Cromer, J Michael Mathis, Daniel N Granger, Ganta V Chaitanya, J Steven Alexander 
World J Gastroenterol 17(5):578-593. Published online Feb 7, 2011. doi: 10.3748/wjg.v17.i5.578
12
Technical skills and training of upper gastrointestinal endoscopy for new beginners  
Seung-Hwa Lee, Young-Kyu Park, Sung-Min Cho, Joon-Koo Kang, Duck-Joo Lee 
World J Gastroenterol 21(3):759-785. Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.759
13
Anemia and iron deficiency in gastrointestinal and liver conditions  
Jürgen Stein, Susan Connor, Garth Virgin, David Eng Hui Ong, Lisandro Pereyra 
World J Gastroenterol 22(35):7908-7925. Published online Sep 21, 2016. doi: 10.3748/wjg.v22.i35.7908
14
15
Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients!  
Anamaria Cozma-Petruţ, Felicia Loghin, Doina Miere, Dan Lucian Dumitraşcu 
World J Gastroenterol 23(21):3771-3783. Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3771
16
Prevalence of IFNL3 rs4803217 single nucleotide polymorphism and clinical course of chronic hepatitis C  
Bogna Świątek-Kościelna, Ewelina Kałużna, Ewa Strauss, Jerzy Nowak, Iwona Bereszyńska, Ewelina Gowin, Jacek Wysocki, Jolanta Rembowska, Dominika Barcińska, Iwona Mozer-Lisewska, Danuta Januszkiewicz-Lewandowska 
World J Gastroenterol 23(21):3815-3824. Published online Jun 7, 2017. doi: 10.3748/wjg.v23.i21.3815
17
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19
Celiac disease: Prevalence, diagnosis, pathogenesis and treatment  
Naiyana Gujral, Hugh J Freeman, Alan BR Thomson 
World J Gastroenterol 18(42):6036-6059. Published online Nov 14, 2012. doi: 10.3748/wjg.v18.i42.6036
20
Gastrointestinal radiation injury: Symptoms, risk factors and mechanisms  
Abobakr K Shadad, Frank J Sullivan, Joseph D Martin, Laurence J Egan 
World J Gastroenterol 19(2):185-198. Published online Jan 14, 2013. doi: 10.3748/wjg.v19.i2.185
21
New trends in molecular and cellular biomarker discovery for colorectal cancer  
Parisa Aghagolzadeh, Ramin Radpour 
World J Gastroenterol 22(25):5678-5693. Published online Jul 7, 2016. doi: 10.3748/wjg.v22.i25.5678
22
Exploring alternative treatments for Helicobacter pylori infection  
Guadalupe Ayala, Wendy Itzel Escobedo-Hinojosa, Carlos Felipe de la Cruz-Herrera, Irma Romero 
World J Gastroenterol 20(6):1450-1469. Published online Feb 14, 2014. doi: 10.3748/wjg.v20.i6.1450
23
Beyond the stomach: An updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment  
Traci L Testerman, James Morris 
World J Gastroenterol 20(36):12781-12808. Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.12781
24
Gut microbiota in autism and mood disorders  
Francesca Mangiola, Gianluca Ianiro, Francesco Franceschi, Stefano Fagiuoli, Giovanni Gasbarrini, Antonio Gasbarrini 
World J Gastroenterol 22(1):361-368. Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.361
25
Nonalcoholic fatty liver disease: Evolving paradigms  
Amedeo Lonardo, Fabio Nascimbeni, Mauro Maurantonio, Alessandra Marrazzo, Luca Rinaldi, Luigi Elio Adinolfi 
World J Gastroenterol 23(36):6571-6592. Published online Sep 28, 2017. doi: 10.3748/wjg.v23.i36.6571
26
Brain-gut-microbiota axis in Parkinson's disease  
Agata Mulak, Bruno Bonaz 
World J Gastroenterol 21(37):10609-10620. Published online Oct 7, 2015. doi: 10.3748/wjg.v21.i37.10609
27
Irritable bowel syndrome: Pathogenesis, diagnosis, treatment, and evidence-based medicine  
Lekha Saha 
World J Gastroenterol 20(22):6759-6773. Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.6759
28
Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer  
Jonathan Landy, Emma Ronde, Nick English, Sue K Clark, Ailsa L Hart, Stella C Knight, Paul J Ciclitira, Hafid Omar Al-Hassi 
World J Gastroenterol 22(11):3117-3126. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3117
29
Treatment options for alcoholic and non-alcoholic fatty liver disease: A review  
Sukhpreet Singh, Natalia A Osna, Kusum K Kharbanda 
World J Gastroenterol 23(36):6549-6570. Published online Sep 28, 2017. doi: 10.3748/wjg.v23.i36.6549
30
Benign gallbladder diseases: Imaging techniques and tips for differentiating with malignant gallbladder diseases  
Mi Hye Yu, Young Jun Kim, Hee Sun Park, Sung Il Jung 
World J Gastroenterol 26(22):2967-2986. Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.2967
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Endoscopic Kyoto classification of Helicobacter pylori infection and gastric cancer risk diagnosis  
Osamu Toyoshima, Toshihiro Nishizawa, Kazuhiko Koike 
World J Gastroenterol 26(5):466-477. Published online Feb 7, 2020. doi: 10.3748/wjg.v26.i5.466
33
Systematic review and meta-analysis of Saccharomyces boulardii in adult patients  
Lynne V McFarland 
World J Gastroenterol 16(18):2202-2222. Published online May 14, 2010. doi: 10.3748/wjg.v16.i18.2202
34
Gut microbiota imbalance and colorectal cancer  
Johan Gagnière, Jennifer Raisch, Julie Veziant, Nicolas Barnich, Richard Bonnet, Emmanuel Buc, Marie-Agnès Bringer, Denis Pezet, Mathilde Bonnet 
World J Gastroenterol 22(2):501-518. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.501
35
Gastroenteric tube feeding: Techniques, problems and solutions  
Irina Blumenstein, Yogesh M Shastri, Jürgen Stein 
World J Gastroenterol 20(26):8505-8524. Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8505
36
Probiotic yeasts: Anti-inflammatory potential of various non-pathogenic strains in experimental colitis in mice  
Benoît Foligné, Joëlle Dewulf, Pascal Vandekerckove, Georges Pignède, Bruno Pot 
World J Gastroenterol 16(17):2134-2145. Published online May 7, 2010. doi: 10.3748/wjg.v16.i17.2134
37
New obesity classification criteria as a tool for bariatric surgery indication  
Antonino De Lorenzo, Laura Soldati, Francesca Sarlo, Menotti Calvani, Nicola Di Lorenzo, Laura Di Renzo 
World J Gastroenterol 22(2):681-703. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.681
38
Diet and nutritional factors in inflammatory bowel diseases  
Danuta Owczarek, Tomasz Rodacki, Renata Domagała-Rodacka, Dorota Cibor, Tomasz Mach 
World J Gastroenterol 22(3):895-905. Published online Jan 21, 2016. doi: 10.3748/wjg.v22.i3.895
39
Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model  
Jun Qian, Elsie Oppermann, Andreas Tran, Ulli Imlau, Kun Qian, Thomas Josef Vogl 
World J Gastroenterol 22(21):5042-5049. Published online Jun 7, 2016. doi: 10.3748/wjg.v22.i21.5042
40
Hepatitis B virus therapy: What’s the future holding for us?  
Sobia Manzoor, Muhammad Saalim, Muhammad Imran, Saleha Resham, Javed Ashraf 
World J Gastroenterol 21(44):12558-12575. Published online Nov 28, 2015. doi: 10.3748/wjg.v21.i44.12558
41
Differentiating Crohn’s disease from intestinal tuberculosis  
Saurabh Kedia, Prasenjit Das, Kumble Seetharama Madhusudhan, Siddhartha Dattagupta, Raju Sharma, Peush Sahni, Govind Makharia, Vineet Ahuja 
World J Gastroenterol 25(4):418-432. Published online Jan 28, 2019. doi: 10.3748/wjg.v25.i4.418
42
Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries  
María José Domper Arnal, Ángel Ferrández Arenas, Ángel Lanas Arbeloa 
World J Gastroenterol 21(26):7933-7943. Published online Jul 14, 2015. doi: 10.3748/wjg.v21.i26.7933
43
Influence of gut microbiota on neuropsychiatric disorders  
María Carmen Cenit, Yolanda Sanz, Pilar Codoñer-Franch 
World J Gastroenterol 23(30):5486-5498. Published online Aug 14, 2017. doi: 10.3748/wjg.v23.i30.5486
44
Pathogenesis and clinical management of Helicobacter pylori gastric infection  
Breno Bittencourt de Brito, Filipe Antônio França da Silva, Aline Silva Soares, Vinícius Afonso Pereira, Maria Luísa Cordeiro Santos, Mariana Miranda Sampaio, Pedro Henrique Moreira Neves, Fabrício Freire de Melo 
World J Gastroenterol 25(37):5578-5589. Published online Oct 7, 2019. doi: 10.3748/wjg.v25.i37.5578
45
Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response  
Behzad Yeganeh, Adel Rezaei Moghadam, Javad Alizadeh, Emilia Wiechec, Seyed Moayed Alavian, Mohammad Hashemi, Bita Geramizadeh, Afshin Samali, Kamran Bagheri Lankarani, Martin Post, Payam Peymani, Kevin M Coombs, Saeid Ghavami 
World J Gastroenterol 21(47):13225-13239. Published online Dec 21, 2015. doi: 10.3748/wjg.v21.i47.13225
46
Stopping or reducing dietary fiber intake reduces constipation and its associated symptoms  
Kok-Sun Ho, Charmaine You Mei Tan, Muhd Ashik Mohd Daud, Francis Seow-Choen 
World J Gastroenterol 18(33):4593-4596. Published online Sep 7, 2012. doi: 10.3748/wjg.v18.i33.4593
47
Clinical epidemiology and disease burden of nonalcoholic fatty liver disease  
Brandon J Perumpail, Muhammad Ali Khan, Eric R Yoo, George Cholankeril, Donghee Kim, Aijaz Ahmed 
World J Gastroenterol 23(47):8263-8276. Published online Dec 21, 2017. doi: 10.3748/wjg.v23.i47.8263
48
Gastric cancer: Current status of lymph node dissection  
Maurizio Degiuli, Giovanni De Manzoni, Alberto Di Leo, Domenico D’Ugo, Erica Galasso, Daniele Marrelli, Roberto Petrioli, Karol Polom, Franco Roviello, Francesco Santullo, Mario Morino 
World J Gastroenterol 22(10):2875-2893. Published online Mar 14, 2016. doi: 10.3748/wjg.v22.i10.2875
49
Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects  
Denisse Bravo, Anilei Hoare, Cristopher Soto, Manuel A Valenzuela, Andrew FG Quest 
World J Gastroenterol 24(28):3071-3089. Published online Jul 28, 2018. doi: 10.3748/wjg.v24.i28.3071
50
Diet therapy for inflammatory bowel diseases: The established and the new  
Franziska Durchschein, Wolfgang Petritsch, Heinz F Hammer 
World J Gastroenterol 22(7):2179-2194. Published online Feb 21, 2016. doi: 10.3748/wjg.v22.i7.2179