Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.155
Peer-review started: May 6, 2015
First decision: July 14, 2015
Revised: July 22, 2015
Accepted: October 13, 2015
Article in press: October 13, 2015
Published online: January 7, 2016
Core tip: Currently, no clear relationship between chronic hepatitis B (CHB) and the prevalence of metabolic syndrome (MetS) could be established, but observations on large patient cohorts reveal some interesting patterns. Surprisingly, male patients with CHB may have lower prevalence of MetS than patients without CHB, but this has not been observed in females. Furthermore, CHB is probably not associated with higher risk of type 2 diabetes mellitus or atherosclerosis. Regarding the clinical outcomes, available data do not sufficiently reveal all of the possible interactions between MetS, its individual components and CHB.