Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.176
Peer-review started: July 29, 2015
First decision: August 31, 2015
Revised: September 15, 2015
Accepted: October 26, 2015
Article in press: October 26, 2015
Published online: January 7, 2016
Core tip: A number of reviews have described autophagy and microRNAs (miRNAs) in the hepatitis B virus (HBV)-related tumorigenesis. However, few reviews have provided insights into the relationships among autophagy, miRNAs, HBV biogenesis and hepatocarcinogenesis. In this review, we describe the emerging role of autophagy and miRNAs in HBV replication and pathogenesis. Recent studies are reviewed in the following sections: (1) the mechanism by which HBV induces autophagy; (2) the effect of HBV-induced autophagy on HBV replication; (3) the relationship between autophagy and HBV in HBV-related hepatocarcinogenesis; (4) the mechanism by which miRNAs affects HBV replication; and (5) the regulation of miRNAs biogenesis by HBV.