Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.284
Peer-review started: May 6, 2015
First decision: September 29, 2015
Revised: October 13, 2015
Accepted: November 9, 2015
Article in press: November 9, 2015
Published online: January 7, 2016
Core tip: Hepatocellular carcinoma is the most common primary hepatic malignant tumor. With widespread use of liver imaging, various cirrhosis-related nodules are more frequently detected in patients with chronic liver disease, while diverse hypervascular hepatic lesions are incidentally detected but undiagnosed on dynamic computed tomography and magnetic resonance imaging (MRI). However, liver MRI using hepatocyte-specific agents has been suggested to be a much more reliable modality in the detection and characterization of focal liver lesions. Therefore, we would like to discuss useful tips for the differentiation of hepatocellular carcinoma from similar lesions in patients with and without chronic liver disease using liver MRI with hepatocyte-specific agents.