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Open-Access Journal
Editorial
Complete radiotherapy response in rectal cancer: A review of the evidence 
Daniel G Couch, David M Hemingway 
World J Gastroenterol 22(2):467-470. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.467
Frontier
Targeted therapies in gastric cancer and future perspectives 
Ozan Yazici, M Ali Nahit Sendur, Nuriye Ozdemir, Sercan Aksoy 
World J Gastroenterol 22(2):471-489. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.471
Topic Highlight
Tropomyosin-related kinase B/brain derived-neurotrophic factor signaling pathway as a potential therapeutic target for colorectal cancer 
Hussein Akil, Aurélie Perraud, Marie-Odile Jauberteau, Muriel Mathonnet 
World J Gastroenterol 22(2):490-500. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.490
Gut microbiota imbalance and colorectal cancer 
Johan Gagnière, Jennifer Raisch, Julie Veziant, Nicolas Barnich, Richard Bonnet, Emmanuel Buc, Marie-Agnès Bringer, Denis Pezet, Mathilde Bonnet 
World J Gastroenterol 22(2):501-518. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.501
Adjuvant chemotherapy for resected colorectal cancer metastases: Literature review and meta-analysis 
Giovanni Brandi, Stefania De Lorenzo, Margherita Nannini, Stefania Curti, Marta Ottone, Filippo Gustavo Dall’Olio, Maria Aurelia Barbera, Maria Abbondanza Pantaleo, Guido Biasco 
World J Gastroenterol 22(2):519-533. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.519
Integration of genome scale data for identifying new players in colorectal cancer 
Viktorija Sokolova, Elisabetta Crippa, Manuela Gariboldi 
World J Gastroenterol 22(2):534-545. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.534
Dealing with robot-assisted surgery for rectal cancer: Current status and perspectives 
Roberto Biffi, Fabrizio Luca, Paolo Pietro Bianchi, Sabina Cenciarelli, Wanda Petz, Igor Monsellato, Manuela Valvo, Maria Laura Cossu, Tiago Leal Ghezzi, Kassem Shmaissany 
World J Gastroenterol 22(2):546-556. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.546
Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer 
Katsuhiko Nosho, Yasutaka Sukawa, Yasushi Adachi, Miki Ito, Kei Mitsuhashi, Hiroyoshi Kurihara, Shinichi Kanno, Itaru Yamamoto, Keisuke Ishigami, Hisayoshi Igarashi, Reo Maruyama, Kohzoh Imai, Hiroyuki Yamamoto, Yasuhisa Shinomura 
World J Gastroenterol 22(2):557-566. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.557
Preoperative selection of patients with colorectal cancer liver metastasis for hepatic resection 
Rafif E Mattar, Faisal Al-alem, Eve Simoneau, Mazen Hassanain 
World J Gastroenterol 22(2):567-581. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.567
Insight to drug delivery aspects for colorectal cancer 
Arvind Gulbake, Aviral Jain, Ashish Jain, Ankit Jain, Sanjay K Jain 
World J Gastroenterol 22(2):582-599. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.582
Approach to the endoscopic resection of duodenal lesions 
Jonathan P Gaspar, Edward B Stelow, Andrew Y Wang 
World J Gastroenterol 22(2):600-617. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.600
Buried bumper syndrome: A complication of percutaneous endoscopic gastrostomy 
Jiri Cyrany, Stanislav Rejchrt, Marcela Kopacova, Jan Bures 
World J Gastroenterol 22(2):618-627. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.618
Endoscopic ultrasonography guided-fine needle aspiration for the diagnosis of solid pancreaticobiliary lesions: Clinical aspects to improve the diagnosis 
Hiroyuki Matsubayashi, Toru Matsui, Yohei Yabuuchi, Kenichiro Imai, Masaki Tanaka, Naomi Kakushima, Keiko Sasaki, Hiroyuki Ono 
World J Gastroenterol 22(2):628-640. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.628
Helicobacter pylori and colorectal neoplasia: Is there a causal link? 
Vasilios Papastergiou, Stylianos Karatapanis, Sotirios D Georgopoulos 
World J Gastroenterol 22(2):649-658. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.649
Review of 500 single incision laparoscopic colorectal surgery cases - Lessons learned 
Deborah S Keller, Juan R Flores-Gonzalez, Sergio Ibarra, Eric M Haas 
World J Gastroenterol 22(2):659-667. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.659
Advances in laparoscopy for acute care surgery and trauma 
Matteo Mandrioli, Kenji Inaba, Alice Piccinini, Andrea Biscardi, Massimo Sartelli, Ferdinando Agresta, Fausto Catena, Roberto Cirocchi, Elio Jovine, Gregorio Tugnoli, Salomone Di Saverio 
World J Gastroenterol 22(2):668-680. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.668
New obesity classification criteria as a tool for bariatric surgery indication 
Antonino De Lorenzo, Laura Soldati, Francesca Sarlo, Menotti Calvani, Nicola Di Lorenzo, Laura Di Renzo 
World J Gastroenterol 22(2):681-703. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.681
Laparoscopic colorectal surgery: Current status and implementation of the latest technological innovations 
Marta Pascual, Silvia Salvans, Miguel Pera 
World J Gastroenterol 22(2):704-717. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.704
Technical feasibility of laparoscopic extended surgery beyond total mesorectal excision for primary or recurrent rectal cancer 
Takashi Akiyoshi 
World J Gastroenterol 22(2):718-726. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.718
Laparoscopic gastric cancer surgery: Current evidence and future perspectives 
Taeil Son, Woo Jin Hyung 
World J Gastroenterol 22(2):727-735. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.727
Single-incision laparoscopic surgery for biliary tract disease 
Shu-Hung Chuang, Chih-Sheng Lin 
World J Gastroenterol 22(2):736-747. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.736
Viro-immune therapy: A new strategy for treatment of pancreatic cancer 
Andrea Marie Ibrahim, Yao-He Wang 
World J Gastroenterol 22(2):748-763. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.748
Management of pancreatic cancer in the elderly 
Oliver Higuera, Ismael Ghanem, Rula Nasimi, Isabel Prieto, Laura Koren, Jaime Feliu 
World J Gastroenterol 22(2):764-775. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.764
Molecular targets for the treatment of pancreatic cancer: Clinical and experimental studies 
Tasuku Matsuoka, Masakazu Yashiro 
World J Gastroenterol 22(2):776-789. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.776
Advances in cryoablation for pancreatic cancer 
Xiao-Mei Luo, Li-Zhi Niu, Ji-Bing Chen, Ke-Cheng Xu 
World J Gastroenterol 22(2):790-800. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.790
Noncoding RNAs and pancreatic cancer 
Juan-Fei Peng, Yan-Yan Zhuang, Feng-Ting Huang, Shi-Neng Zhang 
World J Gastroenterol 22(2):801-814. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.801
Review
Mouse models for the discovery of colorectal cancer driver genes 
Christopher R Clark, Timothy K Starr 
World J Gastroenterol 22(2):815-822. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.815
Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment 
Valery Vilchez, Lilia Turcios, Francesc Marti, Roberto Gedaly 
World J Gastroenterol 22(2):823-832. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.823
Chemokine/chemokine receptor pair CCL20/CCR6 in human colorectal malignancy: An overview 
Vilma Oliveira Frick, Claudia Rubie, Ulrich Keilholz, Pirus Ghadjar 
World J Gastroenterol 22(2):833-841. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.833
Nonampullary duodenal adenoma: Current understanding of its diagnosis, pathogenesis, and clinical management 
Chul-Hyun Lim, Young-Seok Cho 
World J Gastroenterol 22(2):853-861. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.853
Status of hepatitis C virus vaccination: Recent update 
Kouka Saadeldin Abdelwahab, Zeinab Nabil Ahmed Said 
World J Gastroenterol 22(2):862-873. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.862
Minireviews
Hepatocyte transplantation program: Lessons learned and future strategies 
Eugenia Pareja Ibars, Miriam Cortes, Laia Tolosa, Maria José Gómez-Lechón, Slivia López, José Vicente Castell, José Mir 
World J Gastroenterol 22(2):874-886. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.874
Biomarkers of skin toxicity induced by anti-epidermal growth factor receptor antibody treatment in colorectal cancer 
Akiko Kubo, Hironobu Hashimoto, Naoki Takahashi, Yasuhide Yamada 
World J Gastroenterol 22(2):887-894. Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.887