Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.24
Peer-review started: May 20, 2015
First decision: July 14, 2015
Revised: August 6, 2015
Accepted: October 13, 2015
Article in press: October 13, 2015
Published online: January 7, 2016
Core tip: Chronic alcohol consumption is a major cause of liver disease. Stem cells, in particular multipotent mesenchymal stromal cells (MSCs), have been envisioned as a promising tool for the development of therapeutic strategies to treat alcoholic liver diseases (ALD). The advantages of MSC include the regulation of exacerbated inflammatory process, their differentiation into hepatocytes, the production of trophic factors that prevent the apoptosis of parenchymal cells, and the induction of the proliferation of endogenous progenitors. Here, we revise the pathophysiology of ALD to identify therapeutic targets for MSCs. Also, we discuss the rationale to propose an MSC-based therapy to treat ALD.