Systematic Reviews
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2016; 22(1): 446-466
Published online Jan 7, 2016. doi: 10.3748/wjg.v22.i1.446
Distinctive aspects of peptic ulcer disease, Dieulafoy's lesion, and Mallory-Weiss syndrome in patients with advanced alcoholic liver disease or cirrhosis
Borko Nojkov, Mitchell S Cappell
Borko Nojkov, Mitchell S Cappell, Division of Gastroenterology and Hepatology, William Beaumont Hospital, Royal Oak, MI 48073, United States
Borko Nojkov, Mitchell S Cappell, Oakland University William Beaumont School of Medicine, Royal Oak, MI 48073, United States
Author contributions: Nojkov B and Cappell MS designed research, performed research, analyzed data, and wrote the paper; both authors read and approved the final manuscript; both authors contributed equally to the paper.
Conflict-of-interest statement: None for all authors. This paper does not discuss any confidential pharmaceutical data reviewed by Dr. Cappell as a consultant for the United States Food and Drug Administration (FDA) Advisory Committee on Gastrointestinal Drugs. Dr. Cappell is a member of the speaker’s bureau for AstraZeneca. This work does not discuss any drugs produced or marketed by AstraZeneca.
Data sharing statement: No additional data available for this systematic review.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mitchell S Cappell, MD, PhD, Division of Gastroenterology and Hepatology, William Beaumont Hospital, MOB 602, 3535 W. Thirteen Mile Road, Royal Oak, MI 48073, United States. mscappell@yahoo.com
Telephone: +1-248-5511227 Fax: +1-248-5515010
Received: July 29, 2015
Peer-review started: July 30, 2015
First decision: August 31, 2015
Revised: September 11, 2015
Accepted: November 24, 2015
Article in press: November 24, 2015
Published online: January 7, 2016
Core Tip

Core tip: Alcoholism is highly prevalent worldwide and can cause advanced-alcoholic-liver-disease (aALD) from alcoholic hepatitis or cirrhosis. This work systematically reviews the literature on acute-upper-gastrointestinal-bleeding not directly related to portal hypertension in patients with aALD. Such patients have markedly increased risks of peptic ulcers, and worse outcomes from peptic ulcer bleeding than other patients, including refractory bleeding, rebleeding, and mortality. Such patients apparently have increased frequency and mortality of bleeding from Dieulafoy lesions. Such patients have more frequent, more severe, and more rebleeding from Mallory-Weiss-syndrome than non-cirrhotics. Prompt endoscopy, after resuscitation, is essential to diagnose and appropriately treat these patients, using endoscopic therapy when necessary.