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Topic Highlight
Genetic polymorphism in pathogenesis of irritable bowel syndrome 
Cynthia KY Cheung, Justin CY Wu 
World J Gastroenterol 20(47):17693-17698. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17693
Toll-like receptor signaling in colorectal cancer: Carcinogenesis to cancer therapy 
Ting-Ting Li, Shuji Ogino, Zhi Rong Qian 
World J Gastroenterol 20(47):17699-17708. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17699
Achieving the best bowel preparation for colonoscopy 
Adolfo Parra-Blanco, Alex Ruiz, Manuel Alvarez-Lobos, Ana Amorós, Juan Cristóbal Gana, Patricio Ibáñez, Akiko Ono, Takahiro Fujii 
World J Gastroenterol 20(47):17709-17726. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17709
Impact of the gut microbiota on rodent models of human disease 
Axel Kornerup Hansen, Camilla Hartmann Friis Hansen, Lukasz Krych, Dennis Sandris Nielsen 
World J Gastroenterol 20(47):17727-17736. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17727
Intestinal microbiota and type 2 diabetes: From mechanism insights to therapeutic perspective 
Jun-Ling Han, Hui-Ling Lin 
World J Gastroenterol 20(47):17737-17745. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17737
Per-oral endoscopic myotomy: Major advance in achalasia treatment and in endoscopic surgery 
David Friedel, Rani Modayil, Stavros N Stavropoulos 
World J Gastroenterol 20(47):17746-17755. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17746
Review
Pathogenesis of alcoholic liver disease: Role of oxidative metabolism 
Elisabetta Ceni, Tommaso Mello, Andrea Galli 
World J Gastroenterol 20(47):17756-17772. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17756
Procalcitonin and intestinal ischemia: A review of the literature 
Cyril Cosse, Charles Sabbagh, Saïd Kamel, Antoine Galmiche, Jean-Marc Regimbeau 
World J Gastroenterol 20(47):17773-17778. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17773
Helicobacter heilmannii sensu lato: An overview of the infection in humans 
Mario Bento-Miranda, Ceu Figueiredo 
World J Gastroenterol 20(47):17779-17787. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17779
Probiotics for antibiotic-associated diarrhea: Do we have a verdict? 
Iyad Issa, Rami Moucari 
World J Gastroenterol 20(47):17788-17795. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17788
Molecular diagnosis and therapy for occult peritoneal metastasis in gastric cancer patients 
Shunsuke Kagawa, Kunitoshi Shigeyasu, Michihiro Ishida, Megumi Watanabe, Hiroshi Tazawa, Takeshi Nagasaka, Yasuhiro Shirakawa, Toshiyoshi Fujiwara 
World J Gastroenterol 20(47):17796-17803. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17796
Cancer-associated fibroblasts in digestive tumors 
Lei Huang, A-Man Xu, Sha Liu, Wei Liu, Tuan-Jie Li 
World J Gastroenterol 20(47):17804-17818. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17804
Minireviews
Dendritic cells in hepatitis C virus infection: Key players in the IFNL3-genotype response 
Kate S O’Connor, Jacob George, David Booth, Golo Ahlenstiel 
World J Gastroenterol 20(47):17830-17838. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17830
Original Article
Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis 
Yvette Simon, Sonja M Kessler, Katja Gemperlein, Rainer M Bohle, Rolf Müller, Johannes Haybaeck, Alexandra K Kiemer 
World J Gastroenterol 20(47):17839-17850. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17839
Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration 
Katharine M Irvine, Richard Skoien, Nilesh J Bokil, Michelle Melino, Gethin P Thomas, Dorothy Loo, Brian Gabrielli, Michelle M Hill, Matthew J Sweet, Andrew D Clouston, Elizabeth E Powell 
World J Gastroenterol 20(47):17851-17862. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17851
Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells 
Atsushi Shiozaki, Hiroki Shimizu, Daisuke Ichikawa, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Daisuke Iitaka, Shingo Nakashima, Yoshito Nako, Mingyao Liu, Eigo Otsuji 
World J Gastroenterol 20(47):17863-17876. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17863
Study of pruritus in chronic hepatitis C patients 
Kazuyoshi Suzuki, Masaya Tamano, Yasumi Katayama, Toru Kuniyoshi, Kagemasa Kagawa, Hiroshi Takada, Kazutomo Suzuki 
World J Gastroenterol 20(47):17877-17882. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17877
Differential gene expression profiling of gastric intraepithelial neoplasia and early-stage adenocarcinoma 
Xue Xu, Lin Feng, Yu Liu, Wei-Xun Zhou, Ying-Cai Ma, Gui-Jun Fei, Ning An, Yuan Li, Xi Wu, Fang Yao, Shu-Jun Cheng, Xing-Hua Lu 
World J Gastroenterol 20(47):17883-17893. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17883
HIF-1α induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal carcinoma cells 
Na-Na Tang, Hong Zhu, Hong-Jie Zhang, Wei-Feng Zhang, Hai-Lin Jin, Lu Wang, Pin Wang, Gui-Jun He, Bo Hao, Rui-Hua Shi 
World J Gastroenterol 20(47):17894-17904. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17894
Protective effects of terminal ileostomy against bacterial translocation in a rat model of intestinal ischemia/reperfusion injury 
Zhi-Liang Lin, Wen-Kui Yu, Shan-Jun Tan, Kai-Peng Duan, Yi Dong, Xiao-Wu Bai, Lin Xu, Ning Li 
World J Gastroenterol 20(47):17905-17913. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17905
MicroRNA-185 regulates expression of lipid metabolism genes and improves insulin sensitivity in mice with non-alcoholic fatty liver disease 
Xiao-Chen Wang, Xiao-Rong Zhan, Xin-Yu Li, Jun-Jie Yu, Xiao-Min Liu 
World J Gastroenterol 20(47):17914-17923. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17914
Research Report
Proinflammatory effects and molecular mechanisms of interleukin-17 in intestinal epithelial cell line HT-29 
Yi-Lin Wang, Meng Fang, Xiao-Ming Wang, Wei-Yan Liu, Yun-Jiang Zheng, Xu-Bo Wu, Ran Tao 
World J Gastroenterol 20(47):17924-17931. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17924
Evidence-Based Medicine
Lean-non-alcoholic fatty liver disease increases risk for metabolic disorders in a normal weight Chinese population 
Ren-Nan Feng, Shan-Shan Du, Cheng Wang, Yan-Chuan Li, Li-Yan Liu, Fu-Chuan Guo, Chang-Hao Sun 
World J Gastroenterol 20(47):17932-17940. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17932
Retrospective Cohort Study
Risk factors for early rebleeding and mortality in acute variceal hemorrhage 
Jing-Run Zhao, Guang-Chuan Wang, Jin-Hua Hu, Chun-Qing Zhang 
World J Gastroenterol 20(47):17941-17948. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17941
Retrospective Study
Clinicopathological features of small nonfunctioning pancreatic neuroendocrine tumors 
Mariko Furukori, Koji Imai, Hidenori Karasaki, Kenji Watanabe, Kensuke Oikawa, Naoyuki Miyokawa, Masahiko Taniguchi, Hiroyuki Furukawa 
World J Gastroenterol 20(47):17949-17954. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17949
Interventional digital subtraction angiography for small bowel gastrointestinal stromal tumors with bleeding 
Yao-Ting Chen, Hong-Liang Sun, Jiang-Hong Luo, Jia-Yan Ni, Dong Chen, Xiong-Ying Jiang, Jing-Xing Zhou, Lin-Feng Xu 
World J Gastroenterol 20(47):17955-17961. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17955
Small sphincterotomy combined with endoscopic papillary large balloon dilation vs sphincterotomy alone for removal of common bile duct stones 
Shi-Bin Guo, Hua Meng, Zhi-Jun Duan, Chun-Yan Li 
World J Gastroenterol 20(47):17962-17969. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17962
Effect of bilateral supraclavicular postoperative radiotherapy in middle and lower thoracic esophageal carcinoma 
Yi Ren, Chang Su, Yang Zhou, Xiang Zhao, Cheng-Liang Yang, Yong-Yu Liu 
World J Gastroenterol 20(47):17970-17975. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17970
Cost-effectiveness analysis of colon cancer treatments from MOSIAC and No. 16968 trials 
Feng Wen, Ke Yao, Ze-Dong Du, Xiao-Feng He, Peng-Fei Zhang, Rui-Lei Tang, Qiu Li 
World J Gastroenterol 20(47):17976-17984. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17976
Clinical Trials Study
Ultrasound hepatic/renal ratio and hepatic attenuation rate for quantifying liver fat content 
Bo Zhang, Fang Ding, Tian Chen, Liang-Hua Xia, Juan Qian, Guo-Yi Lv 
World J Gastroenterol 20(47):17985-17992. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17985
Prospective Study
Poor agreement between endoscopists and gastrointestinal pathologists for the interpretation of probe-based confocal laser endomicroscopy findings 
Shajan Peter, Leona Council, Ji Young Bang, Helmut Neumann, Klaus Mönkemüller, Shyam Varadarajulu, Charles Melbern Wilcox 
World J Gastroenterol 20(47):17993-18000. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17993
Meta-Analysis
Efficacy and safety of gemcitabine-based chemotherapies in biliary tract cancer: A meta-analysis 
Heng Liu, Qi-Di Zhang, Zheng-Hong Li, Qing-Qing Zhang, Lun-Gen Lu 
World J Gastroenterol 20(47):18001-18012. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18001
Meta-analysis of the efficacy of probiotics in Helicobacter pylori eradication therapy 
Rong Zhu, Kan Chen, Yuan-Yuan Zheng, Hua-Wei Zhang, Jun-Shan Wang, Yu-Jing Xia, Wei-Qi Dai, Fan Wang, Miao Shen, Ping Cheng, Yan Zhang, Cheng-Fen Wang, Jing Yang, Jing-Jing Li, Jie Lu, Ying-Qun Zhou, Chuan-Yong Guo 
World J Gastroenterol 20(47):18013-18021. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18013
Three-field vs two-field lymph node dissection for esophageal cancer: A meta-analysis 
Guo-Wei Ma, Dong-Rong Situ, Qi-Long Ma, Hao Long, Lan-Jun Zhang, Peng Lin, Tie-Hua Rong 
World J Gastroenterol 20(47):18022-18030. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18022
Role of protective stoma in low anterior resection for rectal cancer: A meta-analysis 
Sheng-Wen Wu, Cong-Chao Ma, Yu Yang 
World J Gastroenterol 20(47):18031-18037. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18031
Case Report
Eosinophilic esophagitis in patients with esophageal atresia and chronic dysphagia 
Sirvart Kassabian, Virginia Baez-Socorro, Thomas Sferra, Reinaldo Garcia 
World J Gastroenterol 20(47):18038-18043. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18038
Signet-ring cell carcinoma arising from a fundic gland polyp in the stomach 
Yong Seol Jeong, Sung Eun Kim, Mi-Jung Kwon, Jae Yong Seo, Hyun Lim, Ji Won Park, Ho Suk Kang, Sung Hoon Moon, Jong Hyuk Kim, Choong Kee Park 
World J Gastroenterol 20(47):18044-18047. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18044
Primary large cell neuroendocrine carcinoma in the common bile duct: First Asian case report 
Sung Bae Park, Suk Bae Moon, Young Joon Ryu, Jeana Hong, Yang Hee Kim, Gi Bong Chae, Seong Kweon Hong 
World J Gastroenterol 20(47):18048-18052. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18048
Acute pancreatitis associated with herpes zoster: Case report and literature review 
Zhen Wang, Jun Ye, Yue-Hua Han 
World J Gastroenterol 20(47):18053-18056. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18053
Letters To The Editor
Helicobacter, gamma-glutamyltransferase and cancer: Further intriguing connections 
Maria Franzini, Alessandro Corti, Vanna Fierabracci, Alfonso Pompella 
World J Gastroenterol 20(47):18057-18058. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18057
Hepatocellular carcinoma review: Current treatment, and evidence-based medicine 
Bulent Karaman, Bilal Battal, Sebahattin Sari, Samet Verim 
World J Gastroenterol 20(47):18059-18060. Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18059