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Open-Access Journal
Topic Highlight
Health care-associated hepatitis C virus infection 
Bruno Pozzetto, Meriam Memmi, Olivier Garraud, Xavier Roblin, Philippe Berthelot 
World J Gastroenterol 20(46):17265-17278. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17265
Locally advanced rectal cancer: The importance of a multidisciplinary approach 
Rossana Berardi, Elena Maccaroni, Azzurra Onofri, Francesca Morgese, Mariangela Torniai, Michela Tiberi, Consuelo Ferrini, Stefano Cascinu 
World J Gastroenterol 20(46):17279-17287. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17279
Early-onset colorectal cancer: A separate subset of colorectal cancer 
Irene Osorio Silla, Daniel Rueda, Yolanda Rodríguez, Juan Luis García, Felipe de la Cruz Vigo, José Perea 
World J Gastroenterol 20(46):17288-17296. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17288
Current status of function-preserving surgery for gastric cancer 
Takuro Saito, Yukinori Kurokawa, Shuji Takiguchi, Masaki Mori, Yuichiro Doki 
World J Gastroenterol 20(46):17297-17304. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17297
Alternative splicing of DNA damage response genes and gastrointestinal cancers 
Bahityar Rahmutulla, Kazuyuki Matsushita, Fumio Nomura 
World J Gastroenterol 20(46):17305-17313. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17305
Genetic and phenotypic heterogeneity in tropical calcific pancreatitis 
Sumit Paliwal, Seema Bhaskar, Giriraj R Chandak 
World J Gastroenterol 20(46):17314-17323. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17314
Oxidative stress and inflammatory signaling in cerulein pancreatitis 
Ji Hoon Yu, Hyeyoung Kim 
World J Gastroenterol 20(46):17324-17329. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17324
Video capsule endoscopy: Perspectives of a revolutionary technique 
Simon Bouchard, Mostafa Ibrahim, Andre Van Gossum 
World J Gastroenterol 20(46):17330-17344. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17330
Review
Computed tomography perfusion imaging as a potential imaging biomarker of colorectal cancer 
Koichi Hayano, Takeshi Fujishiro, Dushyant V Sahani, Asami Satoh, Tomoyoshi Aoyagi, Gaku Ohira, Toru Tochigi, Hisahiro Matsubara, Kiyohiko Shuto 
World J Gastroenterol 20(46):17345-17351. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17345
Anti-tumour necrosis factor agent and liver injury: Literature review, recommendations for management 
Roberta Elisa Rossi, Ioanna Parisi, Edward John Despott, Andrew Kenneth Burroughs, James O'Beirne, Dario Conte, Mark Ian Hamilton, Charles Daniel Murray 
World J Gastroenterol 20(46):17352-17359. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17352
Hepatitis B and human immunodeficiency virus co-infection 
Bao-Chau Phung, Philippe Sogni, Odile Launay 
World J Gastroenterol 20(46):17360-17367. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17360
Hematopoietic stem cell transplantation for non-malignant gastrointestinal diseases 
Abdulbaqi Al-toma, Petula Nijeboer, Gerd Bouma, Otto Visser, Chris JJ Mulder 
World J Gastroenterol 20(46):17368-17375. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17368
Original Article
Pea3 expression promotes the invasive and metastatic potential of colorectal carcinoma 
Aruz Mesci, Samira Taeb, Xiaoyong Huang, Rishi Jairath, Darshan Sivaloganathan, Stanley K Liu 
World J Gastroenterol 20(46):17376-17387. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17376
Epidemiology of upper gastrointestinal symptoms in Brazil (EpiGastro): A population-based study according to sex and age group 
Maria do Rosário Dias de Oliveira Latorre, Aline Medeiros da Silva, Décio Chinzon, Jaime N Eisig, Telma RP Dias-Bastos 
World J Gastroenterol 20(46):17388-17398. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17388
Hybrid bioartificial liver support in cynomolgus monkeys with D-galactosamine-induced acute liver failure 
Zhi Zhang, Yi-Chao Zhao, Yuan Cheng, Guo-Deng Jian, Ming-Xin Pan, Yi Gao 
World J Gastroenterol 20(46):17399-17406. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17399
Research Report
Hepatoprotective effect of nitric oxide in experimental model of acute hepatic failure 
Marek Saracyn, Marek Brytan, Robert Zdanowski, Tomasz Ząbkowski, Przemysław Dyrla, Janusz Patera, Stanisław Wojtuń, Wojciech Kozłowski, Zofia Wańkowicz 
World J Gastroenterol 20(46):17407-17415. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17407
T3-induced liver AMP-activated protein kinase signaling: Redox dependency and upregulation of downstream targets 
Luis A Videla, Virginia Fernández, Pamela Cornejo, Romina Vargas, Paula Morales, Juan Ceballo, Alvaro Fischer, Nicolás Escudero, Oscar Escobar 
World J Gastroenterol 20(46):17416-17425. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17416
Lobaplatin inhibits growth of gastric cancer cells by inducing apoptosis 
Chu-Yang Yin, Xiao-Lin Lin, Lei Tian, Ming Ye, Xin-Ying Yang, Xiu-Ying Xiao 
World J Gastroenterol 20(46):17426-17433. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17426
Oesophageal flap valvuloplasty and wrapping suturing prevent gastrooesophageal reflux disease in dogs after oesophageal anastomosis 
Ji-Gang Dai, Quan-Xing Liu, Xu-Feng Den, Jia-Xin Min 
World J Gastroenterol 20(46):17434-17438. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17434
miR-374b-5p suppresses RECK expression and promotes gastric cancer cell invasion and metastasis 
Juan Xie, Zhi-Hui Tan, Xia Tang, Ming-Shu Mo, Yan-Ping Liu, Run-Liang Gan, Yi Li, Li Zhang, Guo-Qing Li 
World J Gastroenterol 20(46):17439-17447. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17439
Evidence-Based Medicine
Pancreaticoduodenectomy with vascular reconstruction for adenocarcinoma of the pancreas with borderline resectability 
Tan To Cheung, Ronnie TP Poon, Kenneth SH Chok, Albert CY Chan, Simon HY Tsang, Wing Chiu Dai, See Ching Chan, Sheung Tat Fan, Chung Mau Lo 
World J Gastroenterol 20(46):17448-17455. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17448
Case Control Study
Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan 
Sawako Kuruma, Naoto Egawa, Masanao Kurata, Goro Honda, Terumi Kamisawa, Junko Ueda, Hiroshi Ishii, Makoto Ueno, Haruhisa Nakao, Mitsuru Mori, Keitaro Matsuo, Satoyo Hosono, Shinichi Ohkawa, Kenji Wakai, Kozue Nakamura, Akiko Tamakoshi, Masanori Nojima, Mami Takahashi, Kazuaki Shimada, Takeshi Nishiyama, Shogo Kikuchi, Yingsong Lin 
World J Gastroenterol 20(46):17456-17462. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17456
Retrospective Study
Extraintestinal manifestations in a large series of Italian inflammatory bowel disease patients 
Maddalena Zippi, Claudia Corrado, Roberta Pica, Eleonora Veronica Avallone, Claudio Cassieri, Daniela De Nitto, Paolo Paoluzi, Piero Vernia 
World J Gastroenterol 20(46):17463-17467. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17463
Outcome of endotherapy for pancreas divisum in patients with acute recurrent pancreatitis 
Alberto Mariani, Milena Di Leo, Maria Chiara Petrone, Paolo Giorgio Arcidiacono, Antonella Giussani, Raffaella Alessia Zuppardo, Giulia Martina Cavestro, Pier Alberto Testoni 
World J Gastroenterol 20(46):17468-17475. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17468
Verification of gene expression profiles for colorectal cancer using 12 internet public microarray datasets 
Yu-Tien Chang, Chung-Tay Yao, Sui-Lung Su, Yu-Ching Chou, Chi-Ming Chu, Chi-Shuan Huang, Harn-Jing Terng, Hsiu-Ling Chou, Thomas Wetter, Kang-Hua Chen, Chi-Wen Chang, Yun-Wen Shih, Ching-Huang Lai 
World J Gastroenterol 20(46):17476-17482. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17476
Prognostic factors for survival after transarterial chemoembolization combined with microwave ablation for hepatocellular carcinoma 
Jia-Yan Ni, Hong-Liang Sun, Yao-Ting Chen, Jiang-Hong Luo, Dong Chen, Xiong-Ying Jiang, Lin-Feng Xu 
World J Gastroenterol 20(46):17483-17490. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17483
Analysis of risk factors for postoperative pancreatic fistula following pancreaticoduodenectomy 
Qi-Yu Liu, Wen-Zhi Zhang, Hong-Tian Xia, Jian-Jun Leng, Tao Wan, Bin Liang, Tao Yang, Jia-Hong Dong 
World J Gastroenterol 20(46):17491-17497. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17491
Clinical Trials Study
Genomic landscape of pancreatic neuroendocrine tumors 
Niklas Gebauer, Christian Schmidt-Werthern, Veronica Bernard, Alfred C Feller, Tobias Keck, Nehara Begum, Dirk Rades, Hendrik Lehnert, Georg Brabant, Christoph Thorns 
World J Gastroenterol 20(46):17498-17506. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17498
Observational Study
Endoscopic non-technical skills team training: The next step in quality assurance of endoscopy training 
Manmeet Matharoo, Adam Haycock, Nick Sevdalis, Siwan Thomas-Gibson 
World J Gastroenterol 20(46):17507-17515. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17507
Cytokine production in patients with cirrhosis and TLR4 polymorphisms 
Juan Camilo Nieto, Elisabet Sánchez, Eva Román, Silvia Vidal, Laia Oliva, Carlos Guarner-Argente, Maria Poca, Xavier Torras, Cándido Juárez, Carlos Guarner, German Soriano 
World J Gastroenterol 20(46):17516-17524. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17516
Clinical epidemiology of ulcerative colitis in Arabs based on the Montréal classification 
Othman R Alharbi, Nahla A Azzam, Ahmed S Almalki, Majid A Almadi, Khalid A Alswat, Nazia Sadaf, Abdulrahman M Aljebreen 
World J Gastroenterol 20(46):17525-17531. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17525
Plasma cathepsin L: A prognostic marker for pancreatic cancer 
Nidhi Singh, Prasenjit Das, Surabhi Gupta, Vikas Sachdev, Siddhartha Srivasatava, Siddhartha Datta Gupta, Ravindra Mohan Pandey, Peush Sahni, Shyam S Chauhan, Anoop Saraya 
World J Gastroenterol 20(46):17532-17540. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17532
Significance of downregulation of liver fatty acid-binding protein in hepatocellular carcinoma 
Masafumi Inoue, Yoshihisa Takahashi, Takeshi Fujii, Masanobu Kitagawa, Toshio Fukusato 
World J Gastroenterol 20(46):17541-17551. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17541
Laterally spreading tumors: Limitations of computed tomography colonography 
Kazutomo Togashi, Kenichi Utano, Shigeyoshi Kijima, Yosuke Sato, Hisanaga Horie, Keijirou Sunada, Alan T Lefor, Hideharu Sugimoto, Yoshikazu Yasuda 
World J Gastroenterol 20(46):17552-17557. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17552
Three-Tesla magnetic resonance elastography for hepatic fibrosis: Comparison with diffusion-weighted imaging and gadoxetic acid-enhanced magnetic resonance imaging 
Hee Sun Park, Young Jun Kim, Mi Hye Yu, Won Hyeok Choe, Sung Il Jung, Hae Jeong Jeon 
World J Gastroenterol 20(46):17558-17567. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17558
Prospective Study
Upper-gastrointestinal bleeding secondary to peptic ulcer disease: Incidence and outcomes 
Samuel Quan, Alexandra Frolkis, Kaylee Milne, Natalie Molodecky, Hong Yang, Elijah Dixon, Chad G Ball, Robert P Myers, Subrata Ghosh, Robert Hilsden, Sander Veldhuyzen van Zanten, Gilaad G Kaplan 
World J Gastroenterol 20(46):17568-17577. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17568
Introducing an enhanced recovery after surgery program in colorectal surgery: A single center experience 
Stefano Bona, Mattia Molteni, Riccardo Rosati, Ugo Elmore, Pietro Bagnoli, Roberta Monzani, Monica Caravaca, Marco Montorsi 
World J Gastroenterol 20(46):17578-17587. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17578
Prevalence, histologic and clinical characteristics of heterotopic gastric mucosa in Chinese patients 
Yu Fang, Lei Chen, Dong-Feng Chen, Wan-Ying Ren, Cai-Fei Shen, Yin Xu, Yi-Ju Xia, Jing-Wen Li, Pu Wang, An-Ran Zhang, Shun-Zi Shao, Xiao-Na Yu, Gui-Yong Peng, Dian-Chun Fang 
World J Gastroenterol 20(46):17588-17594. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17588
Systematic Reviews
Costs of laparoscopic and open liver and pancreatic resection: A systematic review 
Paolo Limongelli, Chiara Vitiello, Andrea Belli, Madhava Pai, Salvatore Tolone, Gianmattia del Genio, Luigi Brusciano, Giovanni Docimo, Nagy Habib, Giulio Belli, Long Richard Jiao, Ludovico Docimo 
World J Gastroenterol 20(46):17595-17602. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17595
Effects of laparoscopic cholecystectomy on lung function: A systematic review 
George D Bablekos, Stylianos A Michaelides, Antonis Analitis, Konstantinos A Charalabopoulos 
World J Gastroenterol 20(46):17603-17617. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17603
Epidemiology of Helicobacter pylori infection among the healthy population in Iran and countries of the Eastern Mediterranean Region: A systematic review of prevalence and risk factors 
Ahad Eshraghian 
World J Gastroenterol 20(46):17618-17625. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17618
Meta-Analysis
Meta-analysis of laparoscopic vs open cholecystectomy in elderly patients 
Stavros A Antoniou, George A Antoniou, Oliver O Koch, Rudolph Pointner, Frank A Granderath 
World J Gastroenterol 20(46):17626-17634. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17626
Helicobacter pylori infection and atopic diseases: Is there a relationship? A systematic review and meta-analysis 
Elena Lionetti, Salvatore Leonardi, Angela Lanzafame, Maria Teresa Garozzo, Martina Filippelli, Stefania Tomarchio, Viviana Ferrara, Carmelo Salpietro, Alfredo Pulvirenti, Ruggiero Francavilla, Carlo Catassi 
World J Gastroenterol 20(46):17635-17647. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17635
Is concomitant radiotherapy necessary with gemcitabine-based chemotherapy in pancreatic cancer? 
Xin Zhang, He-Jing Huang, Dan Feng, De-Jun Yang, Chang-Ming Wang, Qing-Ping Cai 
World J Gastroenterol 20(46):17648-17655. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17648
Case Report
Late onset fulminant Wilson’s disease: A case report and review of the literature 
Ella Weitzman, Orit Pappo, Peretz Weiss, Moshe Frydman, Yael Haviv-Yadid, Ziv Ben Ari 
World J Gastroenterol 20(46):17656-17660. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17656
Rare combination of familial adenomatous polyposis and gallbladder polyps 
Yasuhisa Mori, Norihiro Sato, Nobutaka Matayoshi, Toshihisa Tamura, Noritaka Minagawa, Kazunori Shibao, Aiichiro Higure, Mitsuhiro Nakamoto, Masashi Taguchi, Koji Yamaguchi 
World J Gastroenterol 20(46):17661-17665. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17661
Hirschsprung’s disease in twin to twin transfusion syndrome: A case report 
Hye Won Park, Min Jeng Cho, Wook Youn Kim, Byung Ok Kwak, Min Hee Kim 
World J Gastroenterol 20(46):17666-17669. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17666
Emergency laparoscopic partial splenectomy for ruptured spleen: A case report 
Yun-Qiang Cai, Chun-Lin Li, Hua Zhang, Xin Wang, Bing Peng 
World J Gastroenterol 20(46):17670-17673. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17670
Focal autoimmune pancreatitis and chronic sclerosing sialadenitis mimicking pancreatic cancer and neck metastasis 
Li Sun, Qiang Zhou, David R Brigstock, Su Yan, Ming Xiu, Rong-Li Piao, Yan-Hang Gao, Run-Ping Gao 
World J Gastroenterol 20(46):17674-17679. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17674
Sclerosing cholangitis secondary to bleomycin-iodinated embolization for liver hemangioma 
Shuo Jin, Xiao-Ju Shi, Xiao-Dong Sun, Si-Yuan Wang, Guang-Yi Wang 
World J Gastroenterol 20(46):17680-17685. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17680
Letters To The Editor
Reversal of IgM deficiency following a gluten-free diet in seronegative celiac disease 
Lucia Montenegro, Domenico Piscitelli, Floriana Giorgio, Claudia Covelli, Maria Grazia Fiore, Giuseppe Losurdo, Andrea Iannone, Enzo Ierardi, Alfredo Di Leo, Mariabeatrice Principi 
World J Gastroenterol 20(46):17686-17689. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17686
Diagnostically untypable hepatitis C virus variants: It is time to resolve the problem 
Muhammad Sohail Afzal, Muhammad Yousaf Khan, Muhammad Ammar, Sadia Anjum, Najm us Sahar Sadaf Zaidi 
World J Gastroenterol 20(46):17690-17692. Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17690