Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18057
Revised: June 21, 2014
Accepted: July 29, 2014
Published online: December 21, 2014
Core tip: Biochemical reactions promoted by gamma-glutamyltransferase (GGT) of Helicobacter is capable of causing damage to gastric epithelium and suppression of immune response. Bacterial GGT is secreted as exosome-like vescicles, and very similar GGT-rich exosomes are released from human cancer cells. In the resistant and invasive phenotype of malignant cells, such secreted GGT may play roles akin to those described for Helicobacter infection, concurring to the establishment of cancer metastases.