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World J Gastroenterol. Dec 21, 2014; 20(47): 17932-17940
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17932
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17932
Lean-non-alcoholic fatty liver disease increases risk for metabolic disorders in a normal weight Chinese population
Ren-Nan Feng, Shan-Shan Du, Yan-Chuan Li, Li-Yan Liu, Fu-Chuan Guo, Chang-Hao Sun, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150081, Heilongjiang Province, China
Cheng Wang, Department of Environmental Hygiene, School of Public Health, Harbin Medical University, Harbin 150081, Heilongjiang Province, China
Author contributions: Feng RN, Du SS and Wang C contributed equally to this work; Feng RN and Sun CH designed the research; Wang C, Li YC and Guo FC performed the research; Feng RN, Liu LY and Du SS analyzed the data; Feng RN, Du SS, Liu LY and Wang C wrote the manuscript; Feng RN provided financial support for this work; all the authors were involved in revising the manuscript.
Supported by National Natural Science Fund of China, No. 81130049, No. 81202184; and 12th China Five-Year Scientific and Technical Plan, No. 2012BAI02B02
Correspondence to: Chang-Hao Sun, PhD, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, No. 157 Baojian Street, Nangang District, Harbin 150081, Heilongjiang Province, China. changhao2002sun@gmail.com
Telephone: +86-451-87502881 Fax: +86-451-87502885
Received: April 5, 2014
Revised: June 12, 2014
Accepted: July 11, 2014
Published online: December 21, 2014
Revised: June 12, 2014
Accepted: July 11, 2014
Published online: December 21, 2014
Core Tip
Core tip: Obesity is an important risk factor for non-alcoholic fatty liver disease (NAFLD). NAFLD can also occur in lean subjects. Chinese people have lower body mass index than Americans and Europeans, but a similar prevalence of NAFLD. There might be different metabolic characters in Chinese population. We conducted this study to characterize metabolic features of lean-NAFLD and identify its association with metabolic disorders.