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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2014; 20(47): 18013-18021
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18013
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.18013
Meta-analysis of the efficacy of probiotics in Helicobacter pylori eradication therapy
Rong Zhu, Kan Chen, Yuan-Yuan Zheng, Hua-Wei Zhang, Jun-Shan Wang, Yu-Jing Xia, Wei-Qi Dai, Fan Wang, Miao Shen, Ping Cheng, Yan Zhang, Cheng-Fen Wang, Jing Yang, Jing-Jing Li, Jie Lu, Ying-Qun Zhou, Chuan-Yong Guo, Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
Rong Zhu, Department of First Clinical Medical College, Nanjing Medical University, Nanjing 210000, Jiangsu Province, China
Author contributions: Zhu R, Chen K and Zheng YY contributed equally to this paper; Zhu R, Chen K, Zheng YY, Zhang HW and Wang JS designed the research; Zhu R, Chen K, Xia YJ, Dai WQ, Wang F, Shen M, Cheng P, Zhang Y and Wang CF performed the research; Yang J and Li JJ contributed new analytic tools; Zhu R, Chen K, Lu J and Zhou YQ analyzed the data; Zhu R, Chen K and Zheng YY wrote the paper; Guo CY accepts full responsibility for this paper.
Correspondence to: Chuan-Yong Guo, MD, Professor, Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301 Yanchang Middle Road, Zhabei District, Shanghai 200072, China. guochuanyong@hotmail.com
Telephone: +86-21-66302535 Fax: +86-21-66303983
Received: April 20, 2014
Revised: June 28, 2014
Accepted: July 11, 2014
Published online: December 21, 2014
Revised: June 28, 2014
Accepted: July 11, 2014
Published online: December 21, 2014
Core Tip
Core tip: This systematic review and meta-analysis evaluated the role of probiotics in the standard triple Helicobacter pylori therapy in adults. Using a rigorous and rational search strategy, inclusion criteria, and statistical analyses, we found that supplementary probiotic preparations given during standard triple H. pylori therapy conferred a higher eradication rate, particularly in Asian patients, and a lower incidence of total adverse effects, particularly diarrhea.