Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17756
Revised: May 22, 2014
Accepted: August 13, 2014
Published online: December 21, 2014
Core tip: The goal of this article is to review the mechanisms of alcohol-mediated toxicity in parenchymal and non-parenchymal cells of the liver. Specifically, we highlight the effect of oxidative ethanol metabolites such as acetaldehyde and reactive oxygen species in the development of fat accumulation, fibrosis and deranged immune response.