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World J Gastroenterol. Dec 21, 2014; 20(47): 17756-17772
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17756
Published online Dec 21, 2014. doi: 10.3748/wjg.v20.i47.17756
Pathogenesis of alcoholic liver disease: Role of oxidative metabolism
Elisabetta Ceni, Tommaso Mello, Andrea Galli, Gastroenterology Unit, Department of Experimental and Clinical Biochemical Sciences, University of Florence, 50139 Florence, Italy
Elisabetta Ceni, Tommaso Mello, Andrea Galli, Center of Excellence for Research, Transfer and High Education, DENOthe, University of Florence, 50139 Florence, Italy
Andrea Galli, FiorGen Foundation, 50123 Florence, Italy
Author contributions: Ceni E, Mello T and Galli A solely contributed to this paper.
Correspondence to: Andrea Galli, MD, PhD, Gastroenterology Unit, Department of Experimental and Clinical Biochemical Sciences, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy. a.galli@dfc.unifi.it
Telephone: +39-55-4271419 Fax: +39-55-4222409
Received: March 11, 2014
Revised: May 22, 2014
Accepted: August 13, 2014
Published online: December 21, 2014
Revised: May 22, 2014
Accepted: August 13, 2014
Published online: December 21, 2014
Core Tip
Core tip: The goal of this article is to review the mechanisms of alcohol-mediated toxicity in parenchymal and non-parenchymal cells of the liver. Specifically, we highlight the effect of oxidative ethanol metabolites such as acetaldehyde and reactive oxygen species in the development of fat accumulation, fibrosis and deranged immune response.