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World J Gastroenterol. Dec 14, 2014; 20(46): 17476-17482
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17476
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17476
Verification of gene expression profiles for colorectal cancer using 12 internet public microarray datasets
Yu-Tien Chang, Chi-Ming Chu, Yun-Wen Shih, Division of Biomedical Statistics and Informatics, School of Public Health, National Defense Medical Center, Taipei 114, Taiwan
Yu-Tien Chang, Chi-Ming Chu, Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 114, Taiwan
Chung-Tay Yao, Department of Emergency, Cathay General Hospital, Taipei 106, Taiwan
Sui-Lung Su, Yu-Ching Chou, Ching-Huang Lai, Department of Epidemiology, School of Public Health, National Defense Medical Center, Taipei 114, Taiwan
Chi-Shuan Huang, Division of Colorectal Surgery, Cheng Hsin Rehabilitation Medical Center, Taipei 112, Taiwan
Harn-Jing Terng, Advpharma, Inc., Taipei 221, Taiwan
Hsiu-Ling Chou, Department of Nursing, Far Eastern Memorial Hospital and Oriental Institute of Technology, New Taipei 220, Taiwan
Thomas Wetter, Department of Medical Informatics, Faculty of Medicine, University of Heidelberg, 69120 Heidelberg, Germany
Kang-Hua Chen, Chi-Wen Chang, School of Nursing, College of Medicine, Chang Gung University, Tao-Yuan 333, Taiwan
Author contributions: Chu CM and Chang CW designed the research; Shih YW, Chang YT, Terng HJ and Wetter T performed the research; Chou YC, Su SL, Huang CS, Chou HL, Chen KH and Lai CH analyzed the data; Chu CM and Chang CW wrote the paper.
Correspondence to: Chi-Ming Chu, PhD, Professor, Division of Biomedical Statistics and Informatics, School of Public Health, National Defense Medical Center, No. 161, Section 6, Min-Chuan East Road, Taipei 114, Taiwan. chuchiming@web.de
Telephone: +886-9-63367484 Fax: +886-2-87923147
Received: July 6, 2013
Revised: February 17, 2014
Accepted: March 12, 2014
Published online: December 14, 2014
Revised: February 17, 2014
Accepted: March 12, 2014
Published online: December 14, 2014
Core Tip
Core tip: In the future, the 7-gene (CPEB4, EIF2S3, MGC20553, MS4A1, ANXA3, TNFAIP6 and IL2RB) logistic regression model that showed the best results can be further verified for more samples. Meanwhile, the causal relations are needed to confirm among the selected genes and colorectal cancer (CRC). The expression signature of these CRC-associated genes can be evaluated for early detection of CRC. Early detection can thus improve survival in patients before symptoms are detectable, during treatment, or during remission.