Late onset fulminant Wilson’s disease: A case report and review of the literature

Figure 1 Biochemical parameters and international normalized ratio. Serum ALP and ALT decreased while bilirubin level increased. The INR level increased dramatically, indicating the fulminant course of the disease. ALP: Alkaline phosphatase; ALT: Alanine transaminase; Bil: Bilirubin; INR: International normalized ratio.

Figure 2 Histological evaluation of liver tissue (hematoxylin-eosin staining, × 20). A: Histological examination of liver tissue displayed acute hepatitis with bridging necrosis and advanced fibrosis, macro- and micro-vesicular steatosis; B: Using orcein (copper binding protein stain), accumulation of copper binding protein was revealed.