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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2014; 20(46): 17468-17475
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17468
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17468
Outcome of endotherapy for pancreas divisum in patients with acute recurrent pancreatitis
Alberto Mariani, Milena Di Leo, Maria Chiara Petrone, Paolo Giorgio Arcidiacono, Antonella Giussani, Raffaella Alessia Zuppardo, Giulia Martina Cavestro, Pier Alberto Teston, Gastroenterology and Gastrointestinal Endoscopy Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute - Vita Salute San Raffaele University, 20132 Milan, Italy
Author contributions: Mariani A contributed to design of the study, interpretation data, drafting the manuscript, critical review and final approval of the version to be published; Di Leo M, Petrone MC, Aricidiacono PG, Giussani A, Zuppardo RA and Cavestro GM contributed to patients recritment, interpretation data, drafting the manuscript, and final approval of the version to be published; and Testoni PA contributed to design of the study, interpretation data, drafting the manuscript, critical review and final and final approval of the version to be published.
Correspondence to: Alberto Mariani, MD, Gastroenterology and Gastrointestinal Endoscopy Unit, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute - Vita Salute San Raffaele University, Via Olgettina 60, 20132 Milano, Italy. mariani.alberto@hsr.it
Telephone: +39-2-26432756 Fax: +39-2-26435609
Received: January 28, 2014
Revised: May 9, 2014
Accepted: July 24, 2014
Published online: December 14, 2014
Revised: May 9, 2014
Accepted: July 24, 2014
Published online: December 14, 2014
Core Tip
Core tip: In this paper we compared the outcome of patients with pancreas divisum (PDiv) and recent or previous recurrent acute pancreatitis (RAP) after minor papilla endotherapy or observation, respectively. We confirmed previous findings regarding the benefit of endotherapy in patients with PDiv and RAP. In addition, we showed that effective endotherapy in patients with recent bouts of pancreatitis reduced the risk of developing endoscopic ultrasonography signs of chronic pancreatitis (CP) at a rate similar to that seen in patients without recent episodes of acute pancreatitis who are managed conservatively. However, in a subset of patients, endotherapy, although successful, did not prevent the evolution of endosonographic signs of CP.