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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2014; 20(46): 17324-17329
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17324
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17324
Oxidative stress and inflammatory signaling in cerulein pancreatitis
Ji Hoon Yu, New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 701-310, South Korea
Hyeyoung Kim, Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul 120-749, South Korea
Author contributions: All authors contributed to the manuscript.
Supported by National Research Foundation of Korea grant funded by the Korea government No. 2007-0056092
Correspondence to: Hyeyoung Kim, PhD, Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, South Korea. kim626@yonsei.ac.kr
Telephone: +82-2-21233125 Fax: +82-2-3645781
Received: June 6, 2014
Revised: July 26, 2014
Accepted: September 18, 2014
Published online: December 14, 2014
Revised: July 26, 2014
Accepted: September 18, 2014
Published online: December 14, 2014
Core Tip
Core tip: The pathogenesis of acute pancreatitis is not completely elucidated. Oxidative stress may contribute to the development of acute pancreatitis. Evidence supporting the role of reactive oxygen species and cytokines as a risk for pancreatitis and the concept of antioxidant supplementation as a preventive approach for pancreatitis has been proposed. Here we review the literature on oxidative stress, cytokine expression, inflammatory signaling, and natural antioxidant supplementation using an experimental model of cerulein-induced acute pancreatitis.