Retrospective Study
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World J Gastroenterol. Dec 14, 2014; 20(46): 17463-17467
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17463
Extraintestinal manifestations in a large series of Italian inflammatory bowel disease patients
Maddalena Zippi, Claudia Corrado, Roberta Pica, Eleonora Veronica Avallone, Claudio Cassieri, Daniela De Nitto, Paolo Paoluzi, Piero Vernia
Maddalena Zippi, Roberta Pica, Daniela De Nitto, Unit of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, 00157 Rome, Italy
Claudia Corrado, Eleonora Veronica Avallone, Claudio Cassieri, Paolo Paoluzi, Piero Vernia, Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, “Sapienza”, University of Rome, 00157 Rome, Italy
Author contributions: Zippi M and Cassieri C made substantial contribution to study concept and design; Corrado C, De Nitto D and Avallone EV were involved in acquisition, analysis and interpretation of data; Pica R and Zippi M were involved in drafting the article and revising it critically for important intellectual content; Paoluzi P and Vernia P gave final approval of the version to be published.
Correspondence to: Maddalena Zippi, MD, PhD, Unit of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, Via dei Monti Tiburtini 385, 00157 Rome, Italy.
Telephone: +39-6-41433310 Fax: +39-6-41733847
Received: March 18, 2014
Revised: May 21, 2014
Accepted: July 15, 2014
Published online: December 14, 2014
Core Tip

Core tip: Extraintestinal manifestations (EIMs) are commonly seen in association with inflammatory bowel disease (IBD), both in patients with ulcerative colitis and in those ones with Crohn’s disease. The reported prevalence of EIMs in IBD is highly variable, ranging from 25% to 40%. EIMs can involve any organ or system, even if the musculoskeletal and the dermatologic are the most common ones. Hepatopancreatobiliary, ocular, renal and pulmonary systems may also be affected.