Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan

doi:10.3748/wjg.v20.i46.17456

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Control Study

World J Gastroenterol. Dec 14, 2014; 20(46): 17456-17462
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17456

Table 1 Selected characteristics of cases and controls n (%)

	Casesn = 360	Controlsn = 400
Age, mean ± SD	67.8 ± 8.8	64.8 ± 9.5
Sex
Male	215 (59.7)	226 (56.5)
Female	145 (40.3)	174 (43.5)
BMI, mean ± SD	22.9 ± 3.3	22.8 ± 3.2
History of diabetes
Yes	87 (24.1)	35 (8.7)
No	269 (74.7)	362 (90.5)
Cigarette smoking
Ever	215 (59.7)	198 (49.5)
Never	145 (40.2)	202 (50.5)
Age upon starting smoking (mean ± SD)	21.8 ± 4.8	20.5 ± 4.5
Number of cigarettes smoked per day (mean ± SD)	20.3 ± 9.0	16.2 ± 9.2

BMI: Body mass index.

Table 2 Single-nucleotide polymorphisms profile

Rs number	Gene	Chromosome location	Risk allele¹	Alternative allele
rs1801282	PPARG2	3p25	C	G
rs1501299	ADIPOQ	3q27	C	A
rs4994	ADRB3	8p12	C	T
rs2237895	KCNQ1	11p15	C	A
rs5219	KCNJ11	11q23	T	C
rs7903146	TCF7L2	10q25	T	C
rs2206734	CDKAL1	6p22	A	G

¹Based on the odds ratios reported for the association between T2D risk allele and T2D risk in previous studies.

Table 3 Associations between diabetes-associated single-nucleotide polymorphisms and pancreatic cancer risk

Gene	SNP	Genotype	Case, n	Control, n	Age- and sex-adjusted OR (95%CI)	¹Multivariable-adjusted OR (95%CI)
PPARG2	rs1801282	GG + CG	26	27	1.00	1.00
		CC	334	373	0.83 (0.47-1.46)	0.77 (0.43-1.38)
ADIPOQ	rs1501299	AA	19	38	1.00	1.00
		AC	155	167	1.79 (0.98-3.25)	1.71 (0.93-3.15)
		CC	186	195	1.86 (1.03-3.38)	1.85 (1.01-3.39)
CDKAL1	rs2206734	GG	114	138	1.00	1.00
		AG	184	195	1.15 (0.83-1.59)	1.18 (0.85-1.64)
		AA	62	67	1.16 (0.75-1.79)	1.21 (0.78-1.89)
ADRB3	rs4994	TT	228	255	1.00	1.00
		CT	114	131	0.92 (0.67-1.25)	0.88 (0.64-1.21)
		CC	18	14	1.37 (0.66-2.83)	1.36 (0.65-2.87)
KCNQ1	rs2237895	AA	153	156	1.00	1.00
		AC	175	193	0.95 (0.70-1.29)	0.92 (0.67-1.26)
		CC	32	51	0.62 (0.37-1.02)	0.62 (0.37-1.04)
KCNJ11	rs5219	CC	150	159	1.00	1.00
		CT	157	192	0.87(0.64-1.18)	0.90 (0.66-1.24)
		TT	53	49	1.14 (0.72-1.79)	1.19 (0.75-1.90)
TCF7L2	rs7903146	CC	354	394	1.00	1.00
		CT + TT	6	6	1.20 (0.38-3.83)	1.16 (0.36-3.72)

¹Adjusted for age, sex, body mass index, and cigarette smoking.

Citation: Kuruma S, Egawa N, Kurata M, Honda G, Kamisawa T, Ueda J, Ishii H, Ueno M, Nakao H, Mori M, Matsuo K, Hosono S, Ohkawa S, Wakai K, Nakamura K, Tamakoshi A, Nojima M, Takahashi M, Shimada K, Nishiyama T, Kikuchi S, Lin Y. Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan. World J Gastroenterol 2014; 20(46): 17456-17462
URL: https://www.wjgnet.com/1007-9327/full/v20/i46/17456.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i46.17456