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World J Gastroenterol. Dec 14, 2014; 20(46): 17439-17447
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17439
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17439
miR-374b-5p suppresses RECK expression and promotes gastric cancer cell invasion and metastasis
Juan Xie, Zhi-Hui Tan, Xia Tang, Yan-Ping Liu, Li Zhang, Guo-Qing Li, Department of Gastroenterology, the Second Affiliated Hospital of University of South China, Hengyang 421001, Hunan Province, China
Juan Xie, Ming-Shu Mo, Run-Liang Gan, Yi Li, Department of Diagnostics, Medical College of University of South China, Hengyang 421001, Hunan Province, China
Author contributions: Li GQ and Xie J designed the research; Li GQ, Xie J, Tan ZH and Tang X performed the experiments; Li GQ, Liu YP, Li Y, Gan RL and Zhang L provided the reagents/analytic tools; Li GQ, Xie J and Mo MS analyzed the data and wrote the paper.
Supported by National Natural Science Foundation of China, No. 81071965
Correspondence to: Dr. Guo-Qing Li, Department of Gastroenterology, the Second Affiliated Hospital of University of South China, Jiefang Rd 30, Hengyang 421001, Hunan Province, China. ligq1970@163.com
Telephone: +86-734-8899681 Fax: +86-734-8899994
Received: March 17, 2014
Revised: June 23, 2014
Accepted: July 29, 2014
Published online: December 14, 2014
Revised: June 23, 2014
Accepted: July 29, 2014
Published online: December 14, 2014
Core Tip
Core tip: Abnormal expression of microRNAs (miRNAs) is one of the key mechanisms in cancer development, invasion and metastasis. The results of this study identify aberrant expression of 26 miRNAs in two human gastric cancer cell lines, which included upregulation of miR-374b-5p. The invasive and metastatic ability of cancer cells was decreased by transfection of miR-374b-5p antisense oligonucleotides. Furthermore, reversion-inducing cysteine-rich protein with Kazal motif was identified as a target of miR-374b-5p. These data suggest that miR-374b-5p may be a potential biomarker and diagnostic tool for gastric cancer classification and diagnosis.