Original Article
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 14, 2014; 20(46): 17399-17406
Published online Dec 14, 2014. doi: 10.3748/wjg.v20.i46.17399
Table 1 Serum biochemistry with D-galactosamine administration (n = 15)
Indicators48 h before administration48 h after administrationP
ALT (U/L)28.3 ± 4.7494.2 ± 31.94.09 × 10-18
Ammonia (μmol/L)28.9 ± 3.0149.5 ± 12.33.14 × 10-16
TBiL (μmol/L)1.2 ± 0.216.7 ± 2.11.06 × 10-13
TBA (U/L)6.0 ± 1.451.1 ± 7.32.46 × 10-13
BUN (μmol/L)3.7 ± 0.96.2 ± 0.92.96 × 10-6
Cr (μmol/L)76.7 ± 5.7133.5 ± 6.21.66 × 10-12
ALB (g/L)41.3 ± 1.637.3 ± 0.65.86 × 10-8
Fischer index3.2 ± 0.22.2 ± 0.11.49 × 10-11
Table 2 Hepatocyte changes with hybrid bioartificial liver support
Indicators0 h24 h48 h72 h
Hepatocytes (n× 109)4.1 ± 0.33.9 ± 0.43.8 ± 0.33.0 ± 0.1
P-0.36750.22540.0239
A value0.985 ± 0.1050.919 ± 0.0480.751 ± 0.0240.530 ± 0.053
P-0.39000.06100.0173
Table 3 Liver cell function during hybrid bioartificial liver support system support
Indicator0 h24 h48 h72 h
ALT (IU)25.9 ± 4.228.3 ± 4.931.0 ± 2.672.1 ± 10.7a
AST (IU)22.0 ± 3.627.9 ± 10.031.6 ± 8.068.3 ± 12.7a
LDH (mmol)0.28 ± 0.090.31 ± 0.100.41 ± 0.120.74 ± 0.18a
Urea (mmol)2.28 ± 0.242.02 ± 0.211.82 ± 0.261.69 ± 0.20a
ALB (mg)18.67 ± 2.5717.42 ± 1.7014.86 ± 1.4713.58 ± 1.61a
Table 4 General vital signs of a cynomolgus monkey during treatment
Time (h)Heart rate (per min)PBlood oxygen (%)PRespiratory rate (per min)PArtery blood pressure (mmHg)P
090.5 ± 3.8-99.7 ± 0.5-15.3 ± 1.2-114.6 ± 4.1-
194.1 ± 3.40.00095999.6 ± 0.50.34343613.9 ± 1.40.000528117.9 ± 4.80.000093
292.7 ± 3.80.00574399.1 ± 0.70.00512115.4 ± 2.00.797625116.9 ± 6.40.102480
398.1 ± 3.10.00000299.4 ± 0.50.19342216.8 ± 1.90.006689110.4 ± 4.50.003146
491.9 ± 3.80.27124699.0 ± 0.80.00953515.2 ± 1.40.780352110.5 ± 4.80.002654
589.6 ± 3.50.33050999.6 ± 0.50.67831015.5 ± 2.00.678310108.8 ± 5.90.002654
691.2 ± 4.60.38155799.7 ± 0.5116.4 ± 1.60.003241113.7 ± 4.70.261975
Average92.6 ± 4.4-99.4 ± 0.6-15.5 ± 1.8-113.3 ± 5.8-
Table 5 Survival results
GroupSurvivedSurvival time95%CI
(n)(h)
Control (n = 5)0112.8 ± 2.06108.76-116.84
Experimental (n = 10)5128 ± 3.32121.49-134.51