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Open-Access Journal
Editorial
Withdrawal of anti-tumour necrosis factor α therapy in inflammatory bowel disease 
Konstantinos Papamichael, Severine Vermeire 
World J Gastroenterol 21(16):4773-4778. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4773
Review
Challenges in animal modelling of mesenchymal stromal cell therapy for inflammatory bowel disease 
Raghavan Chinnadurai, Spencer Ng, Vijayakumar Velu, Jacques Galipeau 
World J Gastroenterol 21(16):4779-4787. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4779
Metastatic pancreatic cancer: Is there a light at the end of the tunnel? 
Vanja Vaccaro, Isabella Sperduti, Sabrina Vari, Emilio Bria, Davide Melisi, Carlo Garufi, Carmen Nuzzo, Aldo Scarpa, Giampaolo Tortora, Francesco Cognetti, Michele Reni, Michele Milella 
World J Gastroenterol 21(16):4788-4801. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4788
New endoscopic ultrasound techniques for digestive tract diseases: A comprehensive review 
Fan-Sheng Meng, Zhao-Hong Zhang, Feng Ji 
World J Gastroenterol 21(16):4809-4816. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4809
Basic Study
Murine study of portal hypertension associated endothelin-1 hypo-response 
Nicholas Theodorakis, Mary Maluccio, Nicholas Skill 
World J Gastroenterol 21(16):4817-4828. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4817
Toxoplasma gondii causes death and plastic alteration in the jejunal myenteric plexus 
Eduardo José de Almeida Araújo, Larissa Marchi Zaniolo, Suellen Laís Vicentino, Marcelo Biondaro Góis, Jacqueline Nelisis Zanoni, Aristeu Vieira da Silva, Débora de Mello Gonçales Sant’Ana 
World J Gastroenterol 21(16):4829-4839. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4829
Hydrogen sulfide-induced enhancement of gastric fundus smooth muscle tone is mediated by voltage-dependent potassium and calcium channels in mice 
Xiang-Min Meng, Xu Huang, Chun-Mei Zhang, Dong-Hai Liu, Hong-Li Lu, Young-chul Kim, Wen-Xie Xu 
World J Gastroenterol 21(16):4840-4851. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4840
Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction 
Hai-Lian Shi, Chu-Hsuan Liu, Li-Li Ding, Yu Zheng, Xiao-Yan Fei, Lu Lu, Xue-Ming Zhou, Jian-Ye Yuan, Jian-Qun Xie 
World J Gastroenterol 21(16):4852-4863. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4852
Inflammatory microenvironment and expression of chemokines in hepatocellular carcinoma 
Ke-Qi Han, Xue-Qun He, Meng-Yu Ma, Xiao-Dong Guo, Xue-Min Zhang, Jie Chen, Hui Han, Wei-Wei Zhang, Quan-Gang Zhu, Hua Nian, Li-Jun Ma 
World J Gastroenterol 21(16):4864-4874. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4864
Comparison of two different laparotomy methods for modeling rabbit VX2 hepatocarcinoma 
Zhu Chen, Zhen Kang, En-Hua Xiao, Min Tong, Yu-Dong Xiao, Hua-Bing Li 
World J Gastroenterol 21(16):4875-4882. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4875
Intestinal dendritic cells change in number in fulminant hepatic failure 
Xu Cao, Mei Liu, Peng Wang, Dong-Yan Liu 
World J Gastroenterol 21(16):4883-4893. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4883
Case Control Study
Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques 
Thomas Karlas, Joachim Berger, Nikita Garnov, Franziska Lindner, Harald Busse, Nicolas Linder, Alexander Schaudinn, Bettina Relke, Rima Chakaroun, Michael Tröltzsch, Johannes Wiegand, Volker Keim 
World J Gastroenterol 21(16):4894-4902. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4894
Clinical impact of endoscopy position detecting unit (UPD-3) for a non-sedated colonoscopy 
Masakatsu Fukuzawa, Junichi Uematsu, Shin Kono, Sho Suzuki, Takemasa Sato, Naoko Yagi, Yuichiro Tsuji, Kenji Yagi, Chika Kusano, Takuji Gotoda, Takashi Kawai, Fuminori Moriyasu 
World J Gastroenterol 21(16):4903-4910. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4903
Retrospective Cohort Study
Palliative chemotherapy for gastroesophageal cancer in old and very old patients: A retrospective cohort study at the National Center for Tumor Diseases, Heidelberg 
Anne Katrin Berger, Stefanie Zschaebitz, Christine Komander, Dirk Jäger, Georg Martin Haag 
World J Gastroenterol 21(16):4911-4918. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4911
Proton-pump inhibitors for prevention of upper gastrointestinal bleeding in patients undergoing dialysis 
Young Rim Song, Hyung Jik Kim, Jwa-Kyung Kim, Sung Gyun Kim, Sung Eun Kim 
World J Gastroenterol 21(16):4919-4924. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4919
Retrospective Study
Hepatobiliary complications of alveolar echinococcosis: A long-term follow-up study 
Tilmann Graeter, Franziska Ehing, Suemeyra Oeztuerk, Richard Andrew Mason, Mark Martin Haenle, Wolfgang Kratzer, Thomas Seufferlein, Beate Gruener 
World J Gastroenterol 21(16):4925-4932. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4925
Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients 
Makoto Meguro, Toru Mizuguchi, Toshihiko Nishidate, Kenji Okita, Masayuki Ishii, Shigenori Ota, Tomomi Ueki, Emi Akizuki, Koichi Hirata 
World J Gastroenterol 21(16):4933-4945. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4933
Biliary drainage strategy of unresectable malignant hilar strictures by computed tomography volumetry 
Ei Takahashi, Mitsuharu Fukasawa, Tadashi Sato, Shinichi Takano, Makoto Kadokura, Hiroko Shindo, Yudai Yokota, Nobuyuki Enomoto 
World J Gastroenterol 21(16):4946-4953. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4946
Characteristics of gastric cancer in peptic ulcer patients with Helicobacter pylori infection 
Jae Jin Hwang, Dong Ho Lee, Ae-Ra Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim 
World J Gastroenterol 21(16):4954-4960. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4954
Prognostic value of neutrophil distribution in cholangiocarcinoma 
Zhi-Yuan Mao, Guang-Qing Zhu, Mei Xiong, Li Ren, Li Bai 
World J Gastroenterol 21(16):4961-4968. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4961
Laparoscopic resection of lower rectal cancer with telescopic anastomosis without abdominal incisions 
Shi-Yong Li, Gang Chen, Jun-Feng Du, Guang Chen, Xiao-Jun Wei, Wei Cui, Fu-Yi Zuo, Bo Yu, Xing Dong, Xi-Qing Ji, Qiang Yuan 
World J Gastroenterol 21(16):4969-4974. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4969
Clinical Trials Study
Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis 
Fátima Higuera-de la Tijera, Alfredo I Servín-Caamaño, Aurora E Serralde-Zúñiga, Javier Cruz-Herrera, Eduardo Pérez-Torres, Juan M Abdo-Francis, Francisco Salas-Gordillo, José L Pérez-Hernández 
World J Gastroenterol 21(16):4975-4985. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4975
Moxibustion combined with acupuncture increases tight junction protein expression in Crohn’s disease patients 
Hai-Xia Shang, An-Qi Wang, Chun-Hui Bao, Huan-Gan Wu, Wei-Feng Chen, Lu-Yi Wu, Rong Ji, Ji-Meng Zhao, Yin Shi 
World J Gastroenterol 21(16):4986-4996. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4986
Observational Study
Role of colonoscopy in the diagnostic work-up of bowel endometriosis 
Marco Milone, Antonio Mollo, Mario Musella, Paola Maietta, Loredana Maria Sosa Fernandez, Olena Shatalova, Alessandro Conforti, Gianni Barone, Giuseppe De Placido, Francesco Milone 
World J Gastroenterol 21(16):4997-5001. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4997
Prospective Study
In vivo gastric mucosal histopathology using endocytoscopy 
Hiroki Sato, Haruhiro Inoue, Haruo Ikeda, Chiaki Sato, Chainarong Phlanusittepha, Bu’Hussain Hayee, Esperanza Grace R Santi, Yasutoshi Kobayashi, Shin-ei Kudo 
World J Gastroenterol 21(16):5002-5008. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5002
Pathophysiology of functional heartburn based on Rome III criteria in Japanese patients 
Yasuhiro Tamura, Yasushi Funaki, Shinya Izawa, Akihito Iida, Yoshiharu Yamaguchi, Kazunori Adachi, Naotaka Ogasawara, Makoto Sasaki, Hiroshi Kaneko, Kunio Kasugai 
World J Gastroenterol 21(16):5009-5016. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5009
Usefulness of two-point Dixon fat-water separation technique in gadoxetic acid-enhanced liver magnetic resonance imaging 
Ying Ding, Sheng-Xiang Rao, Cai-Zhong Chen, Ren-Chen Li, Meng-Su Zeng 
World J Gastroenterol 21(16):5017-5022. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5017
Randomized Controlled Trial
Irsogladine maleate and rabeprazole in non-erosive reflux disease: A double-blind, placebo-controlled study 
Takayoshi Suzuki, Masashi Matsushima, Aya Masui, Shingo Tsuda, Jin Imai, Jun Nakamura, Yoko Tsukune, Tetsufumi Uchida, Hiroki Yuhara, Muneki Igarashi, Jun Koike, Tetsuya Mine 
World J Gastroenterol 21(16):5023-5031. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5023
Randomized Clinical Trial
Efficacy of moxifloxacin-based sequential therapy for first-line eradication of Helicobacter pylori infection in gastrointestinal disease 
Jae Jin Hwang, Dong Ho Lee, Ae-Ra Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim 
World J Gastroenterol 21(16):5032-5038. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5032
Evidence-Based Medicine
Hepatitis B virus preS1 deletion is related to viral replication increase and disease progression 
Seoung-Ae Lee, Ki-Jeong Kim, Hong Kim, Won-Hyuk Choi, Yu-Sub Won, Bum-Joon Kim 
World J Gastroenterol 21(16):5039-5048. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5039
Systematic Reviews
Anterior rectopexy for full-thickness rectal prolapse: Technical and functional results 
Jean-Luc Faucheron, Bertrand Trilling, Edouard Girard, Pierre-Yves Sage, Sandrine Barbois, Fabian Reche 
World J Gastroenterol 21(16):5049-5055. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5049
Non-physician endoscopists: A systematic review 
Maximilian Stephens, Luke F Hourigan, Mark Appleyard, George Ostapowicz, Mark Schoeman, Paul V Desmond, Jane M Andrews, Michael Bourke, David Hewitt, David A Margolin, Gerald J Holtmann 
World J Gastroenterol 21(16):5056-5071. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5056
Meta-Analysis
Value of bevacizumab in treatment of colorectal cancer: A meta-analysis 
Chun-Ying Qu, Ying Zheng, Min Zhou, Yi Zhang, Feng Shen, Jia Cao, Lei-Ming Xu 
World J Gastroenterol 21(16):5072-5080. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5072
Relationship between apurinic endonuclease 1 Asp148Glu polymorphism and gastrointestinal cancer risk: An updated meta-analysis 
Zhi-Jun Dai, Yong-Ping Shao, Hua-Feng Kang, Wei Tang, Dan Xu, Yang Zhao, Di Liu, Meng Wang, Peng-Tao Yang, Xi-Jing Wang 
World J Gastroenterol 21(16):5081-5089. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5081
Case Report
Case of arterial hemorrhage after endoscopic papillary large balloon dilation for choledocholithiases using a covered self-expandable metallic stent 
Shuya Shimizu, Itaru Naitoh, Takahiro Nakazawa, Kazuki Hayashi, Katsuyuki Miyabe, Hiromu Kondo, Yuji Nishi, Shuichiro Umemura, Yasuki Hori, Akihisa Kato, Hirotaka Ohara, Takashi Joh 
World J Gastroenterol 21(16):5090-5095. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5090
Endoscopic removal of a tablespoon lodged within the duodenum 
Takashi Watanabe, Kunihiko Aoyagi, Yoshitaka Tomioka, Hideki Ishibashi, Shotaro Sakisaka 
World J Gastroenterol 21(16):5096-5098. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5096
Oxyntic gland adenoma endoscopically mimicking a gastric neuroendocrine tumor: A case report 
Tae-In Lee, Jae-Young Jang, Seungmin Kim, Jung-Wook Kim, Young-Woon Chang, Youn-Wha Kim 
World J Gastroenterol 21(16):5099-5104. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5099
Nonconvulsive status epilepticus disguising as hepatic encephalopathy 
Yong Min Jo, Sung Wook Lee, Sang Young Han, Yang Hyun Baek, Ji Hye Ahn, Won Jong Choi, Ji Young Lee, Sang Ho Kim, Byeol A Yoon 
World J Gastroenterol 21(16):5105-5109. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5105
Management of post-gastrectomy anastomosis site obstruction with a self-expandable metallic stent 
Ra Ri Cha, Sang Soo Lee, Hyunjin Kim, Hong Jun Kim, Tae-Hyo Kim, Woon Tae Jung, Ok Jae Lee, Kyung Soo Bae, Sang-Ho Jeong, Chang Yoon Ha 
World J Gastroenterol 21(16):5110-5114. Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.5110