Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis
Fátima Higuera-de la Tijera, Eduardo Pérez-Torres, Juan M Abdo-Francis, Francisco Salas-Gordillo, José L Pérez-Hernández, Liver Clinic, Gastroenterology Department, Hospital General de México, Dr. Eduardo Liceaga, Mexico City 06720, Mexico
Alfredo I Servín-Caamaño, Javier Cruz-Herrera, Internal Medicine Department, Hospital General de México, Dr. Eduardo Liceaga, Mexico City 06720, Mexico
Aurora E Serralde-Zúñiga, Fundación Mexicana para la Salud A.C, Mexico City 06720, Mexico
Author contributions: Higuera-de la Tijera F designed the study, provided financial support though the “Angeles Espinosa Yglesias 2010” stimulus, supervised the study, reviewed the statistical methods and wrote the final manuscript; Servín-Caamaño AI and Serralde-Zúñiga AE contributed to the acquisition, analysis and interpretation of the data and wrote the manuscript; Cruz-Herrera J, Pérez-Torres E, Abdo-Francis JM and Salas-Gordillo F contributed to the acquisition of data and cared for the patients; Pérez-Hernández JL reviewed the statistical methods and wrote the final manuscript; all of the authors read and approved the final manuscript.
Supported by Fatima Higuera-de la Tijera through the “Angeles Espinosa Yglesias 2010” stimulus granted by the FUNSALUD AC, AMPARO Foundation and FUNDHEPA AC, Mexico.
Ethics approval: The study was reviewed and approved by the “Hospital General de México, Dr. Eduardo Liceaga” Institutional Review Board.
Clinical trial registration: This study is registered at http://clinicaltrials.gov. The registration identification number is NCT02161653.
Informed consent: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest: The authors have not conflict of interest to declare. None of the researchers involved in this study have received fees for serving as a speaker, consultant or as advisory board member for any organization.
Data sharing: Technical appendix, statistical code, and dataset available from the corresponding author at firstname.lastname@example.org. Consent for data sharing was not obtained but the presented data are anonymized and risk of identification is low. No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Fátima Higuera-de la Tijera, MD, MSc, Liver Clinic, Gastroenterology Department, Hospital General de México, Dr. Eduardo Liceaga, Dr. Balmis 148, Mexico City 06720, Mexico. email@example.com
Received: November 28, 2014
Peer-review started: December 1, 2014
First decision: December 26, 2014
Revised: January 16, 2015
Accepted: February 12, 2015
Article in press: February 13, 2015
Published online: April 28, 2015