Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4954
Peer-review started: October 15, 2014
First decision: November 14, 2014
Revised: November 26, 2014
Accepted: January 16, 2015
Article in press: January 16, 2015
Published online: April 28, 2015
Core tip: This is the first study to investigate gastric cancer (GC) incidence in peptic ulcer patients with Helicobacter pylori (H. pylori) infection and to compare GC clinical characteristics between patients with gastric ulcer (GU) and duodenal ulcer (DU) disease. The GC incidence rate and relative risk in GU patients with H. pylori infection were higher than in DU patients. The H. pylori eradication rate was lower in GU than in DU patients, although the success rate of therapy was lower than the failure rate in both groups. Atrophy of surrounding mucosa, intestinal metaplasia and H. pylori eradication therapy were significantly associated with GC.