Toxoplasma gondii causes death and plastic alteration in the jejunal myenteric plexus

doi:10.3748/wjg.v21.i16.4829

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Apr 28, 2015 (publication date) through Sep 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 28, 2015; 21(16): 4829-4839
Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4829

Table 1 Initial and final weight; length, width and area of the jejunum and thickness of the external muscle layer of the jejunum in rats from the control group and infected group

Parameters	CG	IG
Initial body weight (g)	254.8 ± 15.90	262.4 ± 11.29
Final body weight (g)	394.1 ± 14.94¹	419.8 ± 31.53¹
Length (cm)	108.4 ± 5.07	110.4 ± 6.83
Width (cm)	0.96 ± 0.15	0.96 ± 0.15
Area (cm²)	104.35 ± 19.15	106.82 ± 23.53
Muscular fold thickness (μm)	51.40 ± 12.34¹	77.02 ± 42.71¹

¹Significantly different (P < 0.05). IG: Infected group; CG: Control group.

Table 2 Population density and morphometric analysis of the cell body of myenteric neurons labeled with Giemsa, NADHd-p and NOS immunohistochemistry in healthy and infected rats with the ME-49 strain of Toxoplasma gondii during 36 d

Measures	GIEMSA		NADHd-p		NOS
Measures	CG	IG	CG	IG	CG	IG
Number of neurons/cm²	39839.3 ± 5362.3¹	26766.6 ± 2177.6¹	11484.5 ± 2211.8	13155.9 ± 1319.3	7959.0 ± 1290.4¹	10893 ± 1156.3¹
Projection of number of neurons for the organ	4157229.4 ± 559555.1¹	2859215.3 ± 232611.3¹	1198410.1 ± 230807.1	1405318.8 ± 157570.2	735729.9 ± 125754.7¹	939630.1 ± 156871.2¹
Cell body (μm²)	232.5 (187.2-286.0)¹	248.2 (204.4-293.0)¹	146.7 (96.8-202.0)¹	155.8 (108.0-14.8)¹	328.1 ± 2.43¹	344.1 ± 2.2¹
Nucleus (μm²)	99.9 (82.5-115.3)¹	102.6 (88.5-119.2)¹	64.9 (43.7-88.5)¹	76.9 (54.1-99.2)¹	97.5 ± 0.70¹	100.9 ± 0.67¹
Cytoplasm (μm²)	130.8 (99.4-175.1)¹	141.6 (112.1-182.4)¹	79.2 (48.0-115.9)¹	74.2 (48.2-117.4)¹	230.6 ± 2.1¹	243.8 ± 1.9¹
Ratio	0.42 (0.37-0.48)	0.41 (0.37-0.47)	0.44 (0.37-0.51)¹	0.48 (0.40-0.57)¹	0.30 ± 0.002	0.31 ± 0.003

¹For the same neuronal marker, are significantly different (t, P < 0.05). IG: Infected group; CG: Control group.

Table 3 Smaller, medium and larger areas (μm²) of VIPergic varicosities and number of enteric glial cells/mm² from the jejunal myenteric plexus of rats from the Control Group and from the Group infected with oocysts of Toxoplasma gondii ME-49 strain

Parameters	CG	IG
Smaller areas (μm²)	0.46 ± 0.10¹	0.80 ± 0.16¹
Larger areas (μm²)	21.68 ± 5.13	24.50 ± 0.90
Medium areas (μm²)	9.28 ± 5.84	9.51 ± 5.99
Enteric glial cells/mm²	1011.18 ± 25.48¹	807.24 ± 39.98¹

¹Significantly different (t, P < 0.05). IG: Infected group; CG: Control group.

Citation: Araújo EJA, Zaniolo LM, Vicentino SL, Góis MB, Zanoni JN, Silva AVD, Sant’Ana DMG. Toxoplasma gondii causes death and plastic alteration in the jejunal myenteric plexus. World J Gastroenterol 2015; 21(16): 4829-4839
URL: https://www.wjgnet.com/1007-9327/full/v21/i16/4829.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i16.4829