Retrospective Study
Copyright ©The Author(s) 2015.
World J Gastroenterol. Apr 28, 2015; 21(16): 4954-4960
Published online Apr 28, 2015. doi: 10.3748/wjg.v21.i16.4954
Table 1 Baseline characteristics of the patients n (%)
HpGU-GC group(n = 86)HpDU-GC group(n = 35)P value
Age (yr), mean ± SD62.2 ± 10.162.5 ± 13.20.412
Gender0.935
Male68 (79.1)28 (80.0)
Female18 (20.9)7 (20.0)
Complication of peptic ulcer3 (3.5)0 (0.0)0.463
Treatment of cancer0.728
ESD50 (58.1)18 (51.4)
Surgery36 (41.9)17 (48.6)
Table 2 Characteristics of the developed gastric cancer during follow-up n (%)
HpGU-GC(n = 86)HpDU-GC(n = 35)P valueUnivariateanalysis
Annual incidence (yr)0.41%0.11%
Type of cancer0.534-
Early gastric cancer76 (88.4)28 (80.0)
Advanced gastric cancer10 (11.6)7 (20.0)
Location of cancer0.341-
Upper1 (1.2)0 (0.0)
Middle45 (52.3)12 (34.3)
Lower40 (46.5)23 (65.7)
Diagnosis of cancer0.515-
Adenocarcinoma77 (89.5)28 (80.0)
Signet ring cell carcinoma7 (8.1)5 (14.2)
Mixed carcinoma2 (2.4)2 (5.8)
Differentiation of cancer0.134-
Well-differentiated42 (48.8)14 (40.0)
Moderate-differentiated31 (36.0)11 (31.4)
Poor-differentiated13 (15.2)10 (28.6)
T-stage of cancer0.007-
T1a59 (68.6)16 (45.7)
T1b16 (18.6)12 (34.2)
T210 (11.6)3 (8.7)
T31 (1.2)0 (0.0)
T40 (0.0)4 (11.4)
Lauren’s classification0.083-
Intestinal type74 (86.0)23 (65.7)
Diffuse type10 (11.6)12 (34.3)
Mixed type2 (2.4)0 (0.0)
Atrophy of surrounding mucosa0.0410.038
Non-mild12 (14.0)23 (65.7)
Moderate-severe74 (86.0)12 (34.3)
Intestinal metaplasia0.0370.032
Non-mild33 (38.4)30 (85.7)
Moderate-severe53 (61.6)5 (14.3)
H. pylori eradication0.0390.041
Success35 (40.6)17 (48.6)
Failure51 (59.4)18 (51.4)
Mean number of endoscopy until GC onset, mean ± SD5.5 ± 3.24.9 ± 3.50.076-
Mean time until GC onset (yr)3.5 ± 2.43.1 ± 2.70.09-
Table 3 Prognosis of the developed gastric cancer n (%)
HpGU-GC group(n = 86)HpDU-GC group (n = 35)P value
Recurrence of cancer6 (7.0)2 (5.7)0.965
Prognosis of cancer0.347
Alive69 (80.2)28 (80.0)
Death15 (17.5)6 (17.2)
Unknown2 (2.3)1 (2.8)
Table 4 Relative risk of gastric cancer development adjusted by Cox’s proportional hazard model
Relative risk95%CIP value
Group
HpDU-GC1.00--
HpGU-GC1.711.09-2.700.02