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Open-Access Journal
Editorial
Acute appendicitis: What is the gold standard of treatment? 
Cesare Ruffolo, Alain Fiorot, Giulia Pagura, Michele Antoniutti, Marco Massani, Ezio Caratozzolo, Luca Bonariol, Francesco Calia di Pinto, Nicolò Bassi 
World J Gastroenterol 19(47):8799-8807. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8799
Topic Highlight
Surveillance for early diagnosis of hepatocellular carcinoma: How best to do it? 
Edoardo G Giannini, Alessandro Cucchetti, Virginia Erroi, Francesca Garuti, Federica Odaldi, Franco Trevisani 
World J Gastroenterol 19(47):8808-8821. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8808
Hepatocellular carcinoma in chronic hepatitis B patients under antiviral therapy 
John Vlachogiannakos, George Papatheodoridis 
World J Gastroenterol 19(47):8822-8830. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8822
Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma 
María L Bacigalupo, Malena Manzi, Gabriel A Rabinovich, María F Troncoso 
World J Gastroenterol 19(47):8831-8849. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8831
Cellular reprogramming and hepatocellular carcinoma development 
Yun-Wen Zheng, Yun-Zhong Nie, Hideki Taniguchi 
World J Gastroenterol 19(47):8850-8860. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8850
Anti-viral therapy to reduce recurrence and improve survival in hepatitis B virus-related hepatocellular carcinoma 
Toru Ishikawa 
World J Gastroenterol 19(47):8861-8866. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8861
Risk prediction of hepatitis B virus-related hepatocellular carcinoma in the era of antiviral therapy 
Il Han Song, So Mi Kim, Young Kwang Choo 
World J Gastroenterol 19(47):8867-8872. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8867
Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma 
De-Leung Gu, Yen-Hsieh Chen, Jou-Ho Shih, Chi-Hung Lin, Yuh-Shan Jou, Chian-Feng Chen 
World J Gastroenterol 19(47):8873-8879. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8873
Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma 
Chia-Chi Hsu, Hsin-Chen Lee, Yau-Huei Wei 
World J Gastroenterol 19(47):8880-8886. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8880
Prevention of hepatocellular carcinoma in chronic viral hepatitis B and C infection 
Tao Lu, Wai-Kay Seto, Ran-Xu Zhu, Ching-Lung Lai, Man-Fung Yuen 
World J Gastroenterol 19(47):8887-8894. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8887
Effects of antiviral therapy on preventing liver tumorigenesis and hepatocellular carcinoma recurrence 
Zhong-Ming Tan, Bei-Cheng Sun 
World J Gastroenterol 19(47):8895-8901. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8895
Exploitation of host clock gene machinery by hepatitis viruses B and C 
Manlio Vinciguerra, Gianluigi Mazzoccoli, Claudia Piccoli, Tiziana Tataranni, Angelo Andriulli, Valerio Pazienza 
World J Gastroenterol 19(47):8902-8909. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8902
Hepatitis C virus-related mixed cryoglobulinemia: Is genetics to blame? 
Laura Gragnani, Elisa Fognani, Alessia Piluso, Anna Linda Zignego 
World J Gastroenterol 19(47):8910-8915. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8910
Immunological alterations in hepatitis C virus infection 
Vincenza Calvaruso, Antonio Craxì 
World J Gastroenterol 19(47):8916-8923. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8916
Interleukin 28B polymorphisms as predictor of response in hepatitis C virus genotype 2 and 3 infected patients 
Alessandra Mangia, Leonardo Mottola, Rosanna Santoro 
World J Gastroenterol 19(47):8924-8928. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8924
Post-translational modifications of hepatitis C viral proteins and their biological significance 
Jana Hundt, Zhubing Li, Qiang Liu 
World J Gastroenterol 19(47):8929-8939. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8929
Hepatitis C virus protease inhibitor-resistance mutations: Our experience and review 
Shuang Wu, Tatsuo Kanda, Shingo Nakamoto, Fumio Imazeki, Osamu Yokosuka 
World J Gastroenterol 19(47):8940-8948. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8940
Prospects for nucleic acid-based therapeutics against hepatitis C virus 
Chang Ho Lee, Ji Hyun Kim, Seong-Wook Lee 
World J Gastroenterol 19(47):8949-8962. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8949
Antiviral treatment of hepatitis C virus infection and factors affecting efficacy 
Yan Zhu, Song Chen 
World J Gastroenterol 19(47):8963-8973. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8963
Review
Extra-intestinal and long term consequences of Giardia duodenalis infections 
Marie CM Halliez, André G Buret 
World J Gastroenterol 19(47):8974-8985. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8974
Non-microbial approach for Helicobacter pylori as faster track to prevent gastric cancer than simple eradication 
Sang-Ho Park, Napapan Kangwan, Jong-Min Park, Eun-Hee Kim, Ki Baik Hahm 
World J Gastroenterol 19(47):8986-8995. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8986
Minireviews
Digestive cancer surgery in the era of sentinel node and epithelial-mesenchymal transition 
Nadia Peparini 
World J Gastroenterol 19(47):8996-9002. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8996
Pancreatic trauma: A concise review 
Uma Debi, Ravinder Kaur, Kaushal Kishor Prasad, Saroj Kant Sinha, Anindita Sinha, Kartar Singh 
World J Gastroenterol 19(47):9003-9011. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9003
Original Article
Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany 
Hans Scherübl, Brigitte Streller, Roland Stabenow, Hermann Herbst, Michael Höpfner, Christoph Schwertner, Joachim Steinberg, Jan Eick, Wanda Ring, Krishna Tiwari, Sören M Zappe 
World J Gastroenterol 19(47):9012-9019. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9012
Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine 
Daniela Gordillo-Bastidas, Edén Oceguera-Contreras, Adriana Salazar-Montes, Jaime González-Cuevas, Luis Daniel Hernández-Ortega, Juan Armendáriz-Borunda 
World J Gastroenterol 19(47):9020-9033. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9020
Superficial esophageal lesions detected by endoscopic ultrasound enhanced with submucosal edema 
Jian-Jun Li, Long-Jun He, Hong-Bo Shan, Thomas D Wang, Huan Xiong, Li-Ming Chen, Guo-Liang Xu, Xiao-Hai Li, Xin-Xin Huang, Guang-Yu Luo, Yin Li, Rong Zhang 
World J Gastroenterol 19(47):9034-9042. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9034
Brief Article
Small bowel tumors detected and missed during capsule endoscopy: Single center experience 
Edyta S Zagorowicz, Anna M Pietrzak, Ewa Wronska, Jacek Pachlewski, Piotr Rutkowski, Ewa Kraszewska, Jaroslaw Regula 
World J Gastroenterol 19(47):9043-9048. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9043
Serum concentrations of insulin-like growth factor-binding protein 5 in Crohn’s disease 
Gupse Adali, Elif Yorulmaz, Seyma Ozkanli, Celal Ulasoglu, Baris Bayraktar, Alev Orhun, Yasar Colak, Ilyas Tuncer 
World J Gastroenterol 19(47):9049-9056. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9049
Alvarado, Eskelinen, Ohhmann and Raja Isteri Pengiran Anak Saleha Appendicitis scores for diagnosis of acute appendicitis 
Hasan Erdem, Süleyman Çetinkünar, Koray Daş, Enver Reyhan, Cumhur Değer, Mehmet Aziret, Hilmi Bozkurt, Selçuk Uzun, Selim Sözen, Oktay İrkörücü 
World J Gastroenterol 19(47):9057-9062. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9057
Seasonal variations in the onset of ulcerative colitis in Japan 
Shigeo Koido, Toshifumi Ohkusa, Hiroaki Saito, Tetsuji Yokoyama, Tomoyoshi Shibuya, Naoto Sakamoto, Kan Uchiyama, Hiroshi Arakawa, Taro Osada, Akihito Nagahara, Sumio Watanabe, Hisao Tajiri 
World J Gastroenterol 19(47):9063-9068. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9063
Anxiety and depression propensities in patients with acute toxic liver injury 
Jeong Ill Suh, Jeong Kyu Sakong, Kwan Lee, Yong Kook Lee, Jeong Bae Park, Dong Joon Kim, Yeon Seok Seo, Jae Dong Lee, Soon Young Ko, Byung Seok Lee, Seok Hyun Kim, Byung Seok Kim, Young Seok Kim, Heon Ju Lee, In Hee Kim, Joo Hyun Sohn, Tae Yeob Kim, Byung Min Ahn 
World J Gastroenterol 19(47):9069-9076. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9069
Appropriateness, endoscopic findings and contributive yield of pediatric gastrointestinal endoscopy 
Way Seah Lee, Hafizah Zainuddin, Christopher CM Boey, Pei Fan Chai 
World J Gastroenterol 19(47):9077-9083. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9077
Routine lymph node dissection may be not suitable for all intrahepatic cholangiocarcinoma patients: Results of a monocentric series 
Dong-Yu Li, Hai-Bin Zhang, Ning Yang, Yuan Quan, Guang-Shun Yang 
World J Gastroenterol 19(47):9084-9091. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9084
Separate calculation of DW-MRI in assessing therapeutic effect in liver tumors in rats 
Feng Chen, Frederik De Keyzer, Yuan-Bo Feng, Marlein Miranda Cona, Jie Yu, Guy Marchal, Raymond Oyen, Yi-Cheng Ni 
World J Gastroenterol 19(47):9092-9103. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9092
131I-labeled metuximab combined with chemoembolization for unresectable hepatocellular carcinoma 
Qing He, Wu-Sheng Lu, Yang Liu, Yong-Song Guan, An-Ren Kuang 
World J Gastroenterol 19(47):9104-9110. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9104
Meta-Analysis
Efficacy of mosapride plus proton pump inhibitors for treatment of gastroesophageal reflux disease: A systematic review 
Qing Liu, Chen-Chen Feng, Er-Man Wang, Xiu-Juan Yan, Sheng-Liang Chen 
World J Gastroenterol 19(47):9111-9118. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9111
Fast-track rehabilitation vs conventional care in laparoscopic colorectal resection for colorectal malignancy: A meta-analysis 
Ping Li, Fang Fang, Jia-Xun Cai, Dong Tang, Qing-Guo Li, Dao-Rong Wang 
World J Gastroenterol 19(47):9119-9126. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9119
Case Report
Localized type 1 autoimmune pancreatitis superimposed upon preexisting intraductal papillary mucinous neoplasms 
Takahiro Urata, Yoshiki Naito, Yoshihiro Izumi, Yoshi Takekuma, Hiroshi Yokomizo, Michiko Nagamine, Seiji Fukuda, Kenji Notohara, Michio Hifumi 
World J Gastroenterol 19(47):9127-9132. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9127
DOG1 is useful for diagnosis of KIT-negative gastrointestinal stromal tumor of stomach 
Takuya Wada, Satoshi Tanabe, Kenji Ishido, Katsuhiko Higuchi, Tohru Sasaki, Chikatoshi Katada, Mizutomo Azuma, Akira Naruke, Myunguchul Kim, Wasaburo Koizumi, Tetsuo Mikami 
World J Gastroenterol 19(47):9133-9136. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9133
Letters To The Editor
Assessment of proximal gastric accommodation in patients with functional dyspepsia 
Paola Iovino, Antonella Santonicola, Carolina Ciacci 
World J Gastroenterol 19(47):9137-9138. Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9137