Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9049
Revised: September 1, 2013
Accepted: September 15, 2013
Published online: December 21, 2013
Core tip: Previous studies have suggested that insulin-like growth factors are important for the growth and development of visceral smooth muscle. In particular, increased insulin-like growth factor-binding protein 5 expression has been described in inflamed and fibrotic intestinal tissue. In this study, we aim to investigate the possible role of insulin-like growth factor-binding protein 5 in Crohn’s disease with stricture involvement. Crohn’s disease patients had lower serum levels of IGFBP-5 compared to healthy controls. The results of the study suggest that additional research is necessary to explain the low circulating levels of IGFBP-5 in Crohn’s disease patients.