Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9020
Revised: June 19, 2013
Accepted: August 4, 2013
Published online: December 21, 2013
Core tip: This paper shows the protective effect of caffeine in the liver to the constant aggressiveness of a hepatotoxic. Here we present evidence not published before of some molecular mechanisms like inhibition of Snail-1 and activation of Nrf2 that could be involved in this beneficial effect down-regulating pro-fibrogenic genes and up-regulating antioxidant molecules.