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Open-Access Journal
Editorial
Liver physiology and liver diseases in the elderly 
Kazuto Tajiri, Yukihiro Shimizu 
World J Gastroenterol 19(46):8459-8467. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8459
Topic Highlight
Evidence-based appraisal of the upfront treatment for unresectable metastatic colorectal cancer patients 
Giuseppe Aprile, Stefania Eufemia Lutrino, Laura Ferrari, Mariaelena Casagrande, Marta Bonotto, Elena Ongaro, Fabio Puglisi 
World J Gastroenterol 19(46):8474-8488. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8474
Colorectal cancer: Current imaging methods and future perspectives for the diagnosis, staging and therapeutic response evaluation 
Maka Kekelidze, Luigia D’Errico, Michele Pansini, Anthony Tyndall, Joachim Hohmann 
World J Gastroenterol 19(46):8502-8514. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8502
Lymph node staging in colorectal cancer: Old controversies and recent advances 
Annika Resch, Cord Langner 
World J Gastroenterol 19(46):8515-8526. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8515
Different standards for healthy screenees than patients in routine clinics? 
Geir Hoff 
World J Gastroenterol 19(46):8527-8530. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8527
Immunotherapy for colorectal cancer 
Shigeo Koido, Toshifumi Ohkusa, Sadamu Homma, Yoshihisa Namiki, Kazuki Takakura, Keisuke Saito, Zensho Ito, Hiroko Kobayashi, Mikio Kajihara, Kan Uchiyama, Seiji Arihiro, Hiroshi Arakawa, Masato Okamoto, Jianlin Gong, Hisao Tajiri 
World J Gastroenterol 19(46):8531-8542. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8531
Early rehabilitation programs after laparoscopic colorectal surgery: Evidence and criticism 
Duck-Woo Kim, Sung-Bum Kang, Soo-Young Lee, Heung-Kwon Oh, Myung-Hoon In 
World J Gastroenterol 19(46):8543-8551. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8543
Review
Pathophysiology of cystic fibrosis and drugs used in associated digestive tract diseases 
Adriana Haack, Giselle Gonçalves Aragão, Maria Rita Carvalho Garbi Novaes 
World J Gastroenterol 19(46):8552-8561. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8552
Endoscopic tools for the diagnosis and evaluation of celiac disease 
Gianluca Ianiro, Antonio Gasbarrini, Giovanni Cammarota 
World J Gastroenterol 19(46):8562-8570. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8562
Oral manifestation in inflammatory bowel disease: A review 
Kamran B Lankarani, Gholam Reza Sivandzadeh, Shima Hassanpour 
World J Gastroenterol 19(46):8571-8579. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8571
Endoscopic papillary large balloon dilation for the removal of bile duct stones 
Jin Hong Kim, Min Jae Yang, Jae Chul Hwang, Byung Moo Yoo 
World J Gastroenterol 19(46):8580-8594. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8580
Minireviews
Intraductal papillary neoplasm of the bile duct 
Xue-Shuai Wan, Yi-Yao Xu, Jun-Yan Qian, Xiao-Bo Yang, An-Qiang Wang, Lian He, Hai-Tao Zhao, Xin-Ting Sang 
World J Gastroenterol 19(46):8595-8604. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8595
Cognitive-behavioral therapy for the management of irritable bowel syndrome 
Qing-Lin Tang, Guo-Yao Lin, Ming-Qing Zhang 
World J Gastroenterol 19(46):8605-8610. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8605
Original Article
Prognosis of patients with gastric cancer and solitary lymph node metastasis 
Chun-Qiu Chen, Xiao-Jiang Wu, Zhen Yu, Zhao-De Bu, Ke-Qiang Zuo, Zi-Yu Li, Jia-Fu Ji 
World J Gastroenterol 19(46):8611-8618. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8611
P115 promotes growth of gastric cancer through interaction with macrophage migration inhibitory factor 
Xiu-Jun Li, Yi Luo, Yong-Fen Yi 
World J Gastroenterol 19(46):8619-8629. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8619
Clinicopathological and biological significance of cripto overexpression in human colon cancer 
Peng-Cheng Jiang, Ling Zhu, Yu Fan, Hao-Liang Zhao 
World J Gastroenterol 19(46):8630-8637. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8630
Brief Article
Randomized trial in malignant biliary obstruction: Plastic vs partially covered metal stents 
Peter L Moses, Khalid M AlNaamani, Alan N Barkun, Stuart R Gordon, Roger D Mitty, M Stanley Branch, Thomas E Kowalski, Myriam Martel, Viviane Adam 
World J Gastroenterol 19(46):8638-8646. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8638
Clostridium difficile-associated disease: Adherence with current guidelines at a tertiary medical center 
Bryan F Curtin, Yousef Zarbalian, Mark H Flasar, Erik von Rosenvinge 
World J Gastroenterol 19(46):8647-8651. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8647
Assessment of the diagnostic performance and interobserver variability of endocytoscopy in Barrett’s esophagus: A pilot ex-vivo study 
Yutaka Tomizawa, Prasad G Iyer, Louis M Wongkeesong, Navtej S Buttar, Lori S Lutzke, Tsung-Teh Wu, Kenneth K Wang 
World J Gastroenterol 19(46):8652-8658. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8652
Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis 
Martina Galatola, Erasmo Miele, Caterina Strisciuglio, Lorella Paparo, Daniela Rega, Paolo Delrio, Francesca Duraturo, Massimo Martinelli, Giovanni Battista Rossi, Annamaria Staiano, Paola Izzo, Marina De Rosa 
World J Gastroenterol 19(46):8659-8670. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8659
Dietary-suppression of hepatic lipogenic enzyme expression in intact male transgenic mice 
Maria Notarnicola, Maria Gabriella Caruso, Angela Tafaro, Valeria Tutino, Giusy Bianco, Mario Minoia, Antonio Francavilla 
World J Gastroenterol 19(46):8671-8677. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8671
Alanine aminotransferase normalization at week 8 predicts viral response during hepatitis C treatment 
Umit Bilge Dogan, Mustafa Salih Akin, Serkan Yalaki 
World J Gastroenterol 19(46):8678-8686. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8678
Metastatic type 1 gastric carcinoid: A real threat or just a myth? 
Simona Grozinsky-Glasberg, Dimitrios Thomas, Jonathan R Strosberg, Ulrich-Frank Pape, Stephan Felder, Apostolos V Tsolakis, Krystallenia I Alexandraki, Merav Fraenkel, Leonard Saiegh, Petachia Reissman, Gregory Kaltsas, David J Gross 
World J Gastroenterol 19(46):8687-8695. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8687
Risk factors to predict severe postoperative pancreatic fistula following gastrectomy for gastric cancer 
Shuhei Komatsu, Daisuke Ichikawa, Kingo Kashimoto, Takeshi Kubota, Kazuma Okamoto, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Eigo Otsuji 
World J Gastroenterol 19(46):8696-8702. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8696
Long-term follow up of endoscopic resection for type 3 gastric NET 
Yong Hwan Kwon, Seong Woo Jeon, Gwang Ha Kim, Jin Il Kim, Il-Kwun Chung, Sam Ryong Jee, Heung Up Kim, Geom Seog Seo, Gwang Ho Baik, Kee Don Choi, Jeong Seop Moon 
World J Gastroenterol 19(46):8703-8708. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8703
Pattern and distribution of colonic diverticulosis: Analysis of 2877 barium enemas in Thailand 
Varut Lohsiriwat, Wanwarang Suthikeeree 
World J Gastroenterol 19(46):8709-8713. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8709
Intestinal stem cell marker LGR5 expression during gastric carcinogenesis 
Zhi-Xue Zheng, Yu Sun, Zhao-De Bu, Lian-Hai Zhang, Zi-Yu Li, Ai-Wen Wu, Xiao-Jiang Wu, Xiao-Hong Wang, Xiao-Jing Cheng, Xiao-Fang Xing, Hong Du, Jia-Fu Ji 
World J Gastroenterol 19(46):8714-8721. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8714
Conservative treatment of early postoperative small bowel obstruction with obliterative peritonitis 
Jian-Feng Gong, Wei-Ming Zhu, Wen-Kui Yu, Ning Li, Jie-Shou Li 
World J Gastroenterol 19(46):8722-8730. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8722
Preoperative biliary drainage in patients with hilar cholangiocarcinoma undergoing major hepatectomy 
Jun-Jie Xiong, Quentin M Nunes, Wei Huang, Samir Pathak, Ai-Lin Wei, Chun-Lu Tan, Xu-Bao Liu 
World J Gastroenterol 19(46):8731-8739. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8731
Vascular resection in pancreatic adenocarcinoma with portal or superior mesenteric vein invasion 
Gang Pan, Kun-Lin Xie, Hong Wu 
World J Gastroenterol 19(46):8740-8744. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8740
Psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in China 
Su-Wen Li, Kai Wang, Yong-Qiang Yu, Hai-Bao Wang, Yuan-Hai Li, Jian-Ming Xu 
World J Gastroenterol 19(46):8745-8751. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8745
Perirenal space blocking restores gastrointestinal function in patients with severe acute pancreatitis 
Jun-Jun Sun, Zhi-Jie Chu, Wei-Feng Liu, Shi-Fang Qi, Yan-Hui Yang, Peng-Lei Ge, Xiao-Hui Zhang, Wen-Sheng Li, Cheng Yang, Yu-Ming Zhang 
World J Gastroenterol 19(46):8752-8757. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8752
Association between TNF-α and IL-1β genotypes vs Helicobacter pylori infection in Indonesia 
Yang Zhao, Jing-Wen Wang, Tsutomu Tanaka, Akihiro Hosono, Ryosuke Ando, Shinkan Tokudome, Soeripto, FX Ediati Triningsih, Tegu Triono, Suwignyo Sumoharjo, EY Wenny Astuti Achwan, Stephanus Gunawan, Yu-Min Li 
World J Gastroenterol 19(46):8758-8763. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8758
Silencing Bmi-1 enhances the senescence and decreases the metastasis of human gastric cancer cells 
Feng-Lan Gao, Wei-Shan Li, Chun-Ling Liu, Guo-Qiang Zhao 
World J Gastroenterol 19(46):8764-8769. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8764
Meta-Analysis
Meta-analysis of Barrett’s esophagus in China 
Ying Dong, Bing Qi, Xiao-Ying Feng, Chun-Meng Jiang 
World J Gastroenterol 19(46):8770-8779. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8770
Smoking, alcohol consumption, and the risk of extrahepatic cholangiocarcinoma: A meta-analysis 
Xiao-Hua Ye, Jia-Ping Huai, Jin Ding, Yan-Ping Chen, Xue-Cheng Sun 
World J Gastroenterol 19(46):8780-8788. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8780
Case Report
Acute cholestatic hepatitis caused by amoxicillin/clavulanate 
Daniel Oliveira Beraldo, Joanderson Fernandes Melo, Alexandre Vidal Bonfim, Andrei Alkmim Teixeira, Ricardo Alkmim Teixeira, André Loyola Duarte 
World J Gastroenterol 19(46):8789-8792. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8789
Pancreatic solid cystic desmoid tumor: Case report and literature review 
Bin Xu, Ling-Hua Zhu, Jia-Guo Wu, Xian-Fa Wang, Erik Matro, Jun-Jun Ni 
World J Gastroenterol 19(46):8793-8798. Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8793