Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8929
Revised: November 10, 2013
Accepted: December 3, 2013
Published online: December 21, 2013
Core tip: Post-translational modifications (PTMs) are an important step in protein maturation and associated with protein function, activity and/or protein life span. PTMs of viral proteins are often essential for regulation of processes involved in viral infections and can be crucial for infectious virion production. Moreover, identification of PTM sites in viral proteins is particularly useful for the development of antiviral drugs. This overview on PTMs of hepatitis C virus (HCV) proteins discusses how PTMs affect HCV replication and virus-induced pathogenesis.