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World J Gastroenterol. Dec 21, 2013; 19(47): 8929-8939
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8929
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8929
Post-translational modifications of hepatitis C viral proteins and their biological significance
Jana Hundt, Zhubing Li, Qiang Liu, Vaccine and Infectious Disease Organization-International Vaccine Center, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada
Author contributions: Liu Q conceived the idea; Hundt J, Li Z and Liu Q wrote the paper. Hundt J and Li Z contributed equally to this article.
Supported by Canadian Institutes of Health Research, Saskatchewan Health Research Foundation, and Natural Sciences and Engineering Research Council of Canada
Correspondence to: Qiang Liu, PhD, Vaccine and Infectious Disease Organization-International Vaccine Center, University of Saskatchewan, 120 Veterinary Road, Saskatoon, SK S7N 5E3, Canada. qiang.liu@usask.ca
Telephone: +1-306-9661567 Fax: +1-306-9667478
Received: September 17, 2013
Revised: November 10, 2013
Accepted: December 3, 2013
Published online: December 21, 2013
Revised: November 10, 2013
Accepted: December 3, 2013
Published online: December 21, 2013
Core Tip
Core tip: Post-translational modifications (PTMs) are an important step in protein maturation and associated with protein function, activity and/or protein life span. PTMs of viral proteins are often essential for regulation of processes involved in viral infections and can be crucial for infectious virion production. Moreover, identification of PTM sites in viral proteins is particularly useful for the development of antiviral drugs. This overview on PTMs of hepatitis C virus (HCV) proteins discusses how PTMs affect HCV replication and virus-induced pathogenesis.