Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8986
Revised: October 30, 2013
Accepted: November 18, 2013
Published online: December 21, 2013
Core tip: Gastric cancer is a multi-factorial and multi-step disease associated with various risk factors including environmental and pathogenic microbial chronic inflammation. Pharmaceutical intervention and the eradication strategy can provide rapid relief of acute inflammation but fails to correct the underlying cause of chronic inflammation. A non-microbial approach for modulating Helicobacter pylori associated gastric inflammation may be an attractive and rapid alternative to optimize cancer prevention strategies and minimize adverse side effects associated with therapeutic regimens.