Review
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World J Gastroenterol. Dec 21, 2013; 19(47): 8986-8995
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8986
Non-microbial approach for Helicobacter pylori as faster track to prevent gastric cancer than simple eradication
Sang-Ho Park, Napapan Kangwan, Jong-Min Park, Eun-Hee Kim, Ki Baik Hahm
Sang-Ho Park, Napapan Kangwan, Jong-Min Park, Eun-Hee Kim, Ki Baik Hahm, CHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, Seoul 135-081, South Korea
Author contributions: Park SH and Hahm KB wrote the manuscript; Kangwan N, Park JM and Kim EH were involved in editing the manuscript.
Supported by A Grant from the Ministry of Education and Science Technology, No. 2009-0081758, South Korea
Correspondence to: Ki Baik Hahm, MD, PhD, Professor, CHA Cancer Prevention Research Center, CHA Cancer Institute, CHA University, 605 Yeoksam 1-dong, Gangnam-gu, Seoul 135-081, South Korea. hahmkb@cha.ac.kr
Telephone: +82-2-34682869 Fax: +82-2-34682868
Received: August 16, 2013
Revised: October 30, 2013
Accepted: November 18, 2013
Published online: December 21, 2013
Core Tip

Core tip: Gastric cancer is a multi-factorial and multi-step disease associated with various risk factors including environmental and pathogenic microbial chronic inflammation. Pharmaceutical intervention and the eradication strategy can provide rapid relief of acute inflammation but fails to correct the underlying cause of chronic inflammation. A non-microbial approach for modulating Helicobacter pylori associated gastric inflammation may be an attractive and rapid alternative to optimize cancer prevention strategies and minimize adverse side effects associated with therapeutic regimens.