Efficacy of mosapride plus proton pump inhibitors for treatment of gastroesophageal reflux disease: A systematic review

Figure 1 Flow chart of study selection and risk of bias summary. A: Flow chart of study selection; B: Risk of bias summary.

Figure 2 Risk of bias in trials.

Figure 3 Meta-analysis of three trials that used mosapride as combined therapy with proton pump inhibitor compared with placebo in gastroesophageal reflux disease, a fixed-effects model was used and pooled relative rate was the measure of effect size. I², total variation across studies that is attributable to heterogeneity rather than to chance; PRR: Pooled relative rate.

Figure 4 Meta-analysis of three trials that used mosapride as combined therapy with proton pump inhibitor compared with placebo in gastroesophageal reflux disease, a fixed-effects model was used and Hedges’g was the measure of effect size. I², total variation across studies that is attributable to heterogeneity rather than to chance; SMD: Standardized mean difference.