Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8867
Revised: October 23, 2013
Accepted: November 2, 2013
Published online: December 21, 2013
Core tip: This review shows the concepts and perspectives of the risk prediction of hepatitis B virus-related hepatocellular carcinoma. Accurate risk scoring systems to predict hepatocellular carcinoma (HCC) development, derived from independent risk factors integrated in aspects of host, environment, and virus, are necessary for performing the strategic processes such as screening/surveillance, diagnosis, and treatment in high-risk individuals of HCC. Globally standardized consensus for HCC risk prediction models should be established on the basis of simplicity, assessability, and reproducibility of the model characteristics available in real clinical setting.