Separate calculation of DW-MRI in assessing therapeutic effect in liver tumors in rats

Table 1 Average apparent diffusion coefficient of entire tumor before and after treatment (mean ± SD)

Group and time	ADCall (× 10-3 mm2/s)	ADChigh (× 10-3 mm2/s)	ADClow (× 10-3 mm2/s)	ADCperf (× 10-3 mm2/s)
ZD6126
Pre	0.90 ± 0.10	0.68 ± 0.16	1.98 ± 0.75	1.30 ± 0.74
4 h	0.86 ± 0.13	0.73 ± 0.12	1.54 ± 0.87	0.81 ± 0.70
2 d	1.40 ± 0.22	1.13 ± 0.21	2.28 ± 0.54	1.15 ± 0.52
ZDTHA
Pre	0.95 ± 0.08	0.70 ± 0.15	1.25 ± 0.87	1.22 ± 0.77
4 h	0.85 ± 0.08	0.77 ± 0.11	1.21 ± 0.59	0.44 ± 0.50
2 d	1.54 ± 0.21	1.31 ± 0.19	2.28 ± 0.37	0.97 ± 0.36
Control
Pre	0.91 ± 0.04	0.77 ± 0.07	1.82 ± 0.39	1.06 ± 0.37
4 h	0.98 ± 0.11	0.85 ± 0.09	1.76 ± 0.79	1.01 ± 0.80
2 d	1.00 ± 0.06	0.95 ± 0.08	1.90 ± 0.24	1.06 ± 0.27

Pre: Pretreatment; ZD: ZD6126; ZDTHA: ZD6126 + thalidomide; ADC: Apparent diffusion coefficient; ADC_all: Calculated from the entire b value setting (b = 0, 50, 100, 150, 200, 250, 300, 500, 750, 1000 s/mm²); ADC_high: calculated from the high b values (b = 500, 750, 1000 s/mm²); ADC_low: Calculated from the low b values (b = 0, 50, 100 s/mm²); ADC_perf: Calculated from ADC_low-ADC_high.