Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8910
Revised: October 28, 2013
Accepted: November 12, 2013
Published online: December 21, 2013
Core tip: Mixed cryoglobulinemia (MC) is the extrahepatic manifestation most strictly correlated with hepatitis C virus (HCV) infection; it is a benign autoimmune/ lymphoproliferative disorder that evolves to lymphoma in 5%-10% of cases. MC pathogenesis is still poorly understood. Several studies have tried to clarify the pathogenetic basis of MC and have suggested that HCV can trigger such a disorder only in the presence of still-undetermined genetic factors. Here, we attempt to clarify the relationship between HCV-related MC and the host’s genetic background. The data that we report are heterogeneous and sometimes conflicting, so large, multicenter studies are clearly needed.