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For: Hsu CC, Lee HC, Wei YH. Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma. World J Gastroenterol 2013; 19(47): 8880-8886 [PMID: 24379611 DOI: 10.3748/wjg.v19.i47.8880]
URL: https://www.wjgnet.com/1007-9327/full/v19/i47/8880.htm
Number Citing Articles
1
Sachin Shetty, Rajesh Kumar, Sanjay Bharati. Mito-TEMPO, a mitochondria-targeted antioxidant, prevents N-nitrosodiethylamine-induced hepatocarcinogenesis in miceFree Radical Biology and Medicine 2019; 136: 76 doi: 10.1016/j.freeradbiomed.2019.03.037
2
Wan Sun, Changchang Hu, Tianyu Wang, Juan Wang, Jieping Zhang, Furong Gao, Qingjian Ou, Haibin Tian, Caixia Jin, Jingying Xu, Jingfa Zhang, Guo-Tong Xu, Lixia Lu. Glia Maturation Factor Beta as a Novel Biomarker and Therapeutic Target for Hepatocellular CarcinomaFrontiers in Oncology 2021; 11 doi: 10.3389/fonc.2021.744331
3
Masato Higurashi, Tsuyoshi Maruyama, Yusuke Nogami, Fumihiro Ishikawa, Yukiko Yoshida, Kazunori Mori, Ken-ichi Fujita, Motoko Shibanuma. High expression of FOXM1 critical for sustaining cell proliferation in mitochondrial DNA-less liver cancer cellsExperimental Cell Research 2020; 389(1): 111889 doi: 10.1016/j.yexcr.2020.111889
4
Abdul Aziz Mohamed Yusoff. Role of mitochondrial DNA mutations in brain tumorsJournal of Cancer Research and Therapeutics 2015; 11(3): 535 doi: 10.4103/0973-1482.161925
5
Xinyu Liu, Guowang Xu. Recent advances in using mass spectrometry for mitochondrial metabolomics and lipidomics - A reviewAnalytica Chimica Acta 2018; 1037: 3 doi: 10.1016/j.aca.2017.11.080
6
Xilin Geng, Zhimin Geng, Hui Li, Yu Zhang, Jibin Li, Hulin Chang. Over‐expression of TFB2M facilitates cell growth and metastasis via activating ROS‐Akt‐NF‐κB signalling in hepatocellular carcinomaLiver International 2020; 40(7): 1756 doi: 10.1111/liv.14440
7
Fawziah MA Mohammed, Ali Reza Rezaee khorasany, Elaheh Mosaieby, Massoud Houshmand. Mitochondrial A12308G alteration in tRNALeu(CUN) in colorectal cancer samplesDiagnostic Pathology 2015; 10(1) doi: 10.1186/s13000-015-0337-6
8
Jessica H. Hartman, Grover P. Miller, Joel N. Meyer. Toxicological implications of mitochondrial localization of CYP2E1Toxicology Research 2017; 6(3): 273 doi: 10.1039/C7TX00020K
9
Sixi Chen, Xinzhu Bao, Hongzhi Chen, Manli Jia, Wen Li, Luyi Zhang, Runxiao Fan, Hezhi Fang, Liqin Jin, Pablo Evelson. Thyroid Cancer-Associated Mitochondrial DNA Mutation G3842A Promotes Tumorigenicity via ROS-Mediated ERK1/2 ActivationOxidative Medicine and Cellular Longevity 2022; 2022: 1 doi: 10.1155/2022/9982449
10
Serena De Matteis, Andrea Ragusa, Giorgia Marisi, Stefania De Domenico, Andrea Casadei Gardini, Massimiliano Bonafè, Anna Maria Giudetti. Aberrant Metabolism in Hepatocellular Carcinoma Provides Diagnostic and Therapeutic OpportunitiesOxidative Medicine and Cellular Longevity 2018; 2018: 1 doi: 10.1155/2018/7512159
11
Vincent Tambay, Valérie-Ann Raymond, Corentine Goossens, Louise Rousseau, Simon Turcotte, Marc Bilodeau. Metabolomics-Guided Identification of a Distinctive Hepatocellular Carcinoma SignatureCancers 2023; 15(12): 3232 doi: 10.3390/cancers15123232
12
CHIA-CHI HSU, LING-CHIA WU, CHENG-YUAN HSIA, PEN-HUI YIN, CHIN-WEN CHI, TIEN-SHUN YEH, HSIN-CHEN LEE. Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugsOncology Reports 2015; 34(3): 1620 doi: 10.3892/or.2015.4092
13
Kelsey L. McLaughlin, Margaret A.M. Nelson, Hannah S. Coalson, James T. Hagen, McLane M. Montgomery, Ashley R. Wooten, Tonya N. Zeczycki, Nasreen A. Vohra, Kelsey H. Fisher-Wellman. Bioenergetic Phenotyping of DEN-Induced Hepatocellular Carcinoma Reveals a Link Between Adenylate Kinase Isoform Expression and Reduced Complex I-Supported RespirationFrontiers in Oncology 2022; 12 doi: 10.3389/fonc.2022.919880
14
Lei Liu, Huawei Xiao, Guiqing Yang. SPARC Controls Migration and Invasion of Hepatocellular Carcinoma Cells Via Regulating GPD2-Mediated Mitochondrial RespirationBiochemical Genetics 2024;  doi: 10.1007/s10528-024-10682-z
15
Sharon Wu, Mojtaba Akhtari, Houda Alachkar. Characterization of Mutations in the Mitochondrial Encoded Electron Transport Chain Complexes in Acute Myeloid LeukemiaScientific Reports 2018; 8(1) doi: 10.1038/s41598-018-31489-0
16
Wei Xuan, Dandan Song, Youyou Yan, Ming Yang, Yan Sun, Nicoletta Guaragnella. A Potential Role for Mitochondrial DNA in the Activation of Oxidative Stress and Inflammation in Liver DiseaseOxidative Medicine and Cellular Longevity 2020; 2020: 1 doi: 10.1155/2020/5835910
17
Mélissa Léveillé, Jennifer L. Estall. Mitochondrial Dysfunction in the Transition from NASH to HCCMetabolites 2019; 9(10): 233 doi: 10.3390/metabo9100233
18
Yijie Li, Xu Guo, Shanshan Guo, Yang Wang, Lin Chen, Yang Liu, Min Jia, Jiaze An, Kaishan Tao, Jinliang Xing. Next generation sequencing‑based analysis of mitochondrial DNA characteristics in plasma extracellular vesicles of patients with hepatocellular carcinomaOncology Letters 2020; 20(3): 2820 doi: 10.3892/ol.2020.11831
19
Sabine Schmitt, Sabine Schulz, Eva-Maria Schropp, Carola Eberhagen, Alisha Simmons, Wolfgang Beisker, Michaela Aichler, Hans Zischka. Why to compare absolute numbers of mitochondriaMitochondrion 2014; 19: 113 doi: 10.1016/j.mito.2014.06.005
20
Yiming Bi, Bei Yin, Guanjie Fan. Identification of metabolism genes related to hepatocarcinogenesis and progression in type 2 diabetes mellitus via co-expression networks analysisHereditas 2021; 158(1) doi: 10.1186/s41065-021-00177-x
21
Jinqiang Zhang, Melody Baddoo, Chang Han, Michael J. Strong, Jennifer Cvitanovic, Krzysztof Moroz, Srikanta Dash, Erik K. Flemington, Tong Wu. Gene network analysis reveals a novel 22-gene signature of carbon metabolism in hepatocellular carcinomaOncotarget 2016; 7(31): 49232 doi: 10.18632/oncotarget.10249
22
HIROSHI KOBAYASHI, SHOGO IMANAKA, HARUKI NAKAMURA, AYUMI TSUJI. Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (Review)Molecular Medicine Reports 2014; 9(5): 1483 doi: 10.3892/mmr.2014.2057
23
Victoria Chagoya de Sánchez, Enrique Chávez, Gabriela Velasco- Loyden, María Guadalupe Lozano-Rosas, Alejandro Rusbel Aparicio-Cadena. Liver Cancer2018;  doi: 10.5772/intechopen.79923
24
Pushpamala Ramaiah, Indrajit Patra, Anum Abbas, Ali Abdulhussain Fadhil, Mohammad Abohassan, Zahraa Haleem Al-qaim, Noora Mohammed Hameed, Moaed Emran Al-Gazally, Saif Sabbar Kemil Almotlaq, Yasser Fakri Mustafa, Yavar Shiravand. Mitofusin-2 in cancer: Friend or foe?Archives of Biochemistry and Biophysics 2022; 730: 109395 doi: 10.1016/j.abb.2022.109395
25
Chun Wang, Hie-Won Hann, Richard S. Hann, Shaogui Wan, Ronald E. Myers, Zhong Ye, Jinliang Xing, Hushan Yang. Circulating Mitochondrial DNA Content Associated with the Risk of Liver Cirrhosis: A Nested Case–Control StudyDigestive Diseases and Sciences 2015; 60(6): 1707 doi: 10.1007/s10620-015-3523-1
26
Thomas Tu, Magdalena Budzinska, Annette Maczurek, Robert Cheng, Anna Di Bartolomeo, Fiona Warner, Geoffrey McCaughan, Susan McLennan, Nicholas Shackel. Novel Aspects of the Liver Microenvironment in Hepatocellular Carcinoma Pathogenesis and DevelopmentInternational Journal of Molecular Sciences 2014; 15(6): 9422 doi: 10.3390/ijms15069422
27
Li Gao, Min Cao, Guan-hua Du, Xue-mei Qin. Huangqin Decoction Exerts Beneficial Effects on Rotenone-Induced Rat Model of Parkinson's Disease by Improving Mitochondrial Dysfunction and Alleviating Metabolic Abnormality of MitochondriaFrontiers in Aging Neuroscience 2022; 14 doi: 10.3389/fnagi.2022.911924
28
Mengmeng Chang, Qingqing Wang, Xinyu Liu, Xianzhe Shi, Guowang Xu. Facile Synthesis of Antibody-Coupled Polydopamine-Coated Magnetic Graphene Oxide Composites for Efficient Immunopurification and Metabolomics Analysis of MitochondriaAnalytical Chemistry 2021; 93(32): 11099 doi: 10.1021/acs.analchem.1c01101
29
Arthur Zimmermann. Tumors and Tumor-Like Lesions of the Hepatobiliary Tract2017; : 3091 doi: 10.1007/978-3-319-26956-6_171
30
Rosendo García-Carrillo, Francisco A. Molina-Pelayo, David Zarate-Lopez, Alejandro Cabrera-Aguilar, Bibiana Ortega-Domínguez, Mariana Domínguez-López, Natalia Chiquete-Félix, Adan Dagnino-Acosta, Gabriela Velasco-Loyden, Enrique Chávez, Luis Castro-Sánchez, Victoria Chagoya de Sánchez. An adenosine derivative promotes mitochondrial supercomplexes reorganization and restoration of mitochondria structure and bioenergetics in a diethylnitrosamine-induced hepatocellular carcinoma modelScientific Reports 2024; 14(1) doi: 10.1038/s41598-024-56306-9
31
Wei Zhou, Zizhen Zhao, Zhenyao Yu, Yixue Hou, Rajendiran Keerthiga, Ailing Fu. Mitochondrial transplantation therapy inhibits the proliferation of malignant hepatocellular carcinoma and its mechanismMitochondrion 2022; 65: 11 doi: 10.1016/j.mito.2022.04.004
32
Ling Li, Hie-Won Hann, Shaogui Wan, Richard S. Hann, Chun Wang, Yinzhi Lai, Xishan Ye, Alison Evans, Ronald E. Myers, Zhong Ye, Bingshan Li, Jinliang Xing, Hushan Yang. Cell-free circulating mitochondrial DNA content and risk of hepatocellular carcinoma in patients with chronic HBV infectionScientific Reports 2016; 6(1) doi: 10.1038/srep23992
33
Arthur Zimmermann. Tumors and Tumor-Like Lesions of the Hepatobiliary Tract2016; : 1 doi: 10.1007/978-3-319-26587-2_171-1
34
Xiaoliang Li, Quanlin Wu, Fujun Ma, Xinxin Zhang, Lei Cai, Xuekang Yang. Mitochondrial fission factor promotes cisplatin resistance<?A3B2 ACK?>in hepatocellular carcinomaActa Biochimica et Biophysica Sinica 2022; 54(3): 301 doi: 10.3724/abbs.2022007
35
Aaron K. Holley, Daret K. St. Clair. Redox-Active TherapeuticsOxidative Stress in Applied Basic Research and Clinical Practice 2016; : 11 doi: 10.1007/978-3-319-30705-3_3
36
C Tang, Y Hou, H Wang, K Wang, H Xiang, X Wan, Y Xia, J Li, W Wei, S Xu, Z Lei, T M Pawlik, H Wang, M Wu, F Shen. Aspartate β-hydroxylase disrupts mitochondrial DNA stability and function in hepatocellular carcinomaOncogenesis 2017; 6(7): e362 doi: 10.1038/oncsis.2017.64
37
Miriam Longo, Erika Paolini, Marica Meroni, Paola Dongiovanni. Remodeling of Mitochondrial Plasticity: The Key Switch from NAFLD/NASH to HCCInternational Journal of Molecular Sciences 2021; 22(8): 4173 doi: 10.3390/ijms22084173
38
Haoming Xia, Ziyue Huang, Yi Xu, Judy Wai Ping Yam, Yunfu Cui. Reprogramming of central carbon metabolism in hepatocellular carcinomaBiomedicine & Pharmacotherapy 2022; 153: 113485 doi: 10.1016/j.biopha.2022.113485
39
Ana Santos-Llamas, Maria J. Monte, Jose J. G. Marin, Maria J. Perez. Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudineArchives of Toxicology 2018; 92(6): 2109 doi: 10.1007/s00204-018-2200-5
40
Yu Zhang, Hui Li, Hulin Chang, Lixue Du, Jun Hai, Xilin Geng, Xiang Yan. MTP18 overexpression contributes to tumor growth and metastasis and associates with poor survival in hepatocellular carcinomaCell Death & Disease 2018; 9(10) doi: 10.1038/s41419-018-0987-x
41
Lateef A. Sulaimon, Rahmat A. Adisa, Titilola A. Samuel, Fatimah B. Abdulkareem, Akinrinade G. Ayankojo. Mitoquinol mesylate alleviates oxidative damage in cirrhotic and advanced hepatocellular carcinogenic rats through mitochondrial protection and antioxidative effectsAdvances in Redox Research 2021; 3: 100014 doi: 10.1016/j.arres.2021.100014
42
Eun‐Ran Park, Sang‐Bum Kim, Jee‐San Lee, Yang‐Hyun Kim, Dong‐Hyoung Lee, Eung‐Ho Cho, Sun‐Hoo Park, Chul Ju Han, Bu‐Yeo Kim, Dong Wook Choi, Young Do Yoo, Ami Yu, Jae Won Lee, Ja June Jang, Young Nyun Park, Kyung‐Suk Suh, Kee‐Ho Lee. The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinomaCancer Medicine 2017; 6(4): 749 doi: 10.1002/cam4.1042
43
Maphuti T. Lebelo, Anna M. Joubert, Michelle H. Visagie. Warburg effect and its role in tumourigenesisArchives of Pharmacal Research 2019; 42(10): 833 doi: 10.1007/s12272-019-01185-2
44
Chien-Yu Chen, Jingyu Chen, Anketse Debebe, Yang Li, Bangyan Stiles. Mitochondria in Liver DiseaseOxidative Stress and Disease 2015; : 45 doi: 10.1201/b19420-5
45
Jose J.G. Marin, Elisa Lozano, Maria J. Perez. Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through ROS-AMPK-ULK1 signaling dysregulation independently of HIF-1αFree Radical Biology and Medicine 2016; 101: 71 doi: 10.1016/j.freeradbiomed.2016.09.025
46
Sachin Shetty, U. Anushree, Rajesh Kumar, Sanjay Bharati. Mitochondria-targeted antioxidant, mito-TEMPO mitigates initiation phase of N-Nitrosodiethylamine-induced hepatocarcinogenesisMitochondrion 2021; 58: 123 doi: 10.1016/j.mito.2021.03.001
47
Xingzhao Ji, Zhen Yang, Chensheng Li, Suwei Zhu, Yu Zhang, Fuyuan Xue, Shengnan Sun, Tingting Fu, Can Ding, Yi Liu, Qiang Wan. Mitochondrial ribosomal protein L12 potentiates hepatocellular carcinoma by regulating mitochondrial biogenesis and metabolic reprogrammingMetabolism 2024; 152: 155761 doi: 10.1016/j.metabol.2023.155761
48
Qiudong Xia, Jinchi Lan, Yuxiang Pan, Yuxin Wang, Tianyuan Song, Ying Yang, Xu Tian, Longjun Chen, Zhenyu Gu, Yin-Yi Ding. Effects of Dityrosine on Lactic Acid Metabolism in Mice Gastrocnemius Muscle During Endurance Exercise via the Oxidative Stress-Induced Mitochondria DamageJournal of Agricultural and Food Chemistry 2024; 72(10): 5269 doi: 10.1021/acs.jafc.3c09649
49
Eman T. Elsayed, Mohamed M. Hashad, Iman E. Elgohary. Mitochondrial DNA Copy Number Variation as a Potential Predictor of Renal Cell CarcinomaThe International Journal of Biological Markers 2017; 32(3): 313 doi: 10.5301/ijbm.5000268
50
Haoming Xia, Ziyue Huang, Zhensheng Wang, Shuqiang Liu, Xudong Zhao, Junqi You, Yi Xu, Judy Wai Ping Yam, Yunfu Cui. Glucometabolic reprogramming: From trigger to therapeutic target in hepatocellular carcinomaFrontiers in Oncology 2022; 12 doi: 10.3389/fonc.2022.953668
51
Hulin Chang, Jibin Li, Ying Luo, Bing Wu, Chong Yuan, Xilin Geng. TFB2M activates aerobic glycolysis in hepatocellular carcinoma cells through the NAD+/SIRT3/HIF‐1α signalingJournal of Gastroenterology and Hepatology 2021; 36(10): 2978 doi: 10.1111/jgh.15548
52
Xufei Zhang, Xiuwen Wu, Qiongyuan Hu, Jie Wu, Gefei Wang, Zhiwu Hong, Jianan Ren. Mitochondrial DNA in liver inflammation and oxidative stressLife Sciences 2019; 236: 116464 doi: 10.1016/j.lfs.2019.05.020
53
Domenico Spadafora, Natalia Kozhukhar, Mikhail F. Alexeyev, Yidong Bai. Presequence-Independent Mitochondrial Import of DNA Ligase Facilitates Establishment of Cell Lines with Reduced mtDNA Copy NumberPLOS ONE 2016; 11(3): e0152705 doi: 10.1371/journal.pone.0152705
54
Maria Lane, Veronika Boczonadi, Sahar Bachtari, Aurora Gomez‐Duran, Thorsten Langer, Alexandra Griffiths, Stephanie Kleinle, Christine Dineiger, Angela Abicht, Elke Holinski‐Feder, Ulrike Schara, Patrick Gerner, Rita Horvath. Mitochondrial dysfunction in liver failure requiring transplantationJournal of Inherited Metabolic Disease 2016; 39(3): 427 doi: 10.1007/s10545-016-9927-z
55
Boya Peng, Shuqing Liu, Chunmei Guo, Xujuan Sun, Ming-Zhong Sun. ANXA5 level is linked to in vitro and in vivo tumor malignancy and lymphatic metastasis of murine hepatocarcinoma cellFuture Oncology 2016; 12(1): 31 doi: 10.2217/fon.15.289
56
Abdul Aziz Mohamed Yusoff, Fatin Najwa Zulfakhar, Siti Zulaikha Nashwa Mohd Khair, Wan Salihah Wan Abdullah, Jafri Malin Abdullah, Zamzuri Idris. Mitochondrial 10398A>G NADH-Dehydrogenase Subunit 3 of Complex I Is Frequently Altered in Intra-Axial Brain Tumors in MalaysiaBrain Tumor Research and Treatment 2018; 6(1): 31 doi: 10.14791/btrt.2018.6.e5
57
Edyta Janik-Karpinska, Michal Ceremuga, Marcin Niemcewicz, Ewelina Synowiec, Tomasz Sliwiński, Michal Bijak. Mitochondrial Damage Induced by T-2 Mycotoxin on Human Skin—Fibroblast Hs68 Cell LineMolecules 2023; 28(5): 2408 doi: 10.3390/molecules28052408
58
Yelei Cen, Guohua Lou, Jinjin Qi, Min Zheng, Yanning Liu. A new perspective on mesenchymal stem cell-based therapy for liver diseases: restoring mitochondrial functionCell Communication and Signaling 2023; 21(1) doi: 10.1186/s12964-023-01230-0
59
Mónica G. Silva, Daniela Mendes, M. Manuel Oliveira, Paula B. Andrade, Romeu A. Videira, Francisco Peixoto. Mitochondrial Intoxication2023; : 493 doi: 10.1016/B978-0-323-88462-4.00012-2
60
P. Wainwright, E. Scorletti, C. D. Byrne. Type 2 Diabetes and Hepatocellular Carcinoma: Risk Factors and PathogenesisCurrent Diabetes Reports 2017; 17(4) doi: 10.1007/s11892-017-0851-x
61
Mahsa Liaghat, Mohammad Yaghoubzad-Maleki, Mohsen Nabi-Afjadi, Zeinab Fathi, Hamidreza Zalpoor, Nafiseh Heidari, Elham Bahreini. A Review of the Potential Role of CoQ10 in the Treatment of Hepatocellular CarcinomaBiochemical Genetics 2024; 62(2): 575 doi: 10.1007/s10528-023-10490-x
62
Snigdha Bhowmick, Vandana Singh, Sandipan Jash, Megha Lal, Soumya Sinha Roy. Mitochondrial metabolism and calcium homeostasis in the development of NAFLD leading to hepatocellular carcinomaMitochondrion 2021; 58: 24 doi: 10.1016/j.mito.2021.01.007
63
H.S. Qsee, Prasad Kisan Tambe, Shounak De, Sanjay Bharati. MitoQ demonstrates connexin- and p53-mediated cancer chemoprevention in N-nitrosodiethylamine-induced hepatocarcinogenesis rodent modelToxicology and Applied Pharmacology 2022; 453: 116211 doi: 10.1016/j.taap.2022.116211
64
Jahnavi Sharma, Roshani Kumari, Arpit Bhargava, Rajnarayan Tiwari, Pradyumna K. Mishra. Mitochondrial-induced Epigenetic Modifications: From Biology to Clinical TranslationCurrent Pharmaceutical Design 2021; 27(2): 159 doi: 10.2174/1381612826666200826165735
65
Jiao Feng, Jingjing Li, Liwei Wu, Qiang Yu, Jie Ji, Jianye Wu, Weiqi Dai, Chuanyong Guo. Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinomaJournal of Experimental & Clinical Cancer Research 2020; 39(1) doi: 10.1186/s13046-020-01629-4
66
Rahmat Adetutu Adisa, Lateef Adegboyega Sulaimon, Ebele Geraldine Okeke, Olubukola Christianah Ariyo, Fatimah B. Abdulkareem. Mitoquinol mesylate (MITOQ) attenuates diethyl nitrosamine-induced hepatocellular carcinoma through modulation of mitochondrial antioxidant defense systemsToxicological Research 2022; 38(3): 275 doi: 10.1007/s43188-021-00105-1
67
Tianqiang Jin, Chao Wang, Yu Tian, Chaoliu Dai, Yuwen Zhu, Feng Xu. Mitochondrial metabolic reprogramming: An important player in liver cancer progressionCancer Letters 2020; 470: 197 doi: 10.1016/j.canlet.2019.11.029
68
Yang-Hsiang Lin, Yu-De Chu, Siew-Na Lim, Chun-Wei Chen, Chau-Ting Yeh, Wey-Ran Lin. Impact of an MT-RNR1 Gene Polymorphism on Hepatocellular Carcinoma Progression and Clinical CharacteristicsInternational Journal of Molecular Sciences 2021; 22(3): 1119 doi: 10.3390/ijms22031119
69
Lourdes Sainero-Alcolado, Judit Liaño-Pons, María Victoria Ruiz-Pérez, Marie Arsenian-Henriksson. Targeting mitochondrial metabolism for precision medicine in cancerCell Death & Differentiation 2022; 29(7): 1304 doi: 10.1038/s41418-022-01022-y