Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8873
Revised: November 20, 2013
Accepted: December 5, 2013
Published online: December 21, 2013
Core tip: In addition to detecting somatic mutations in cancer genomes with high-throughput short-read sequencing technologies, analysis of copy number alteration in hepatocellular carcinoma (HCC) cancer genomes genotyped by high density single nucleotide polymorphism arrays is a cost-effective approach to reveal genome-wide somatic alterations accumulated during tumorigenesis. Integration with other genomic data from HCC tissues derived from high-throughput short-read sequencing, proteomics, epigenomics and transcriptomics could provide lines of evidence to identify common and novel HCC genes for potential clinical applications.