Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.9133
Revised: September 24, 2013
Accepted: October 19, 2013
Published online: December 21, 2013
Core tip: We describe our experience with a rare case of a KIT-negative gastrointestinal stromal tumor (GIST) of the stomach that was diagnosed by positive immunohistochemical staining for Discovered on GIST-1 (DOG1) in a patient who presented with severe anemia. Our findings suggest that immunohistochemical staining for DOG1, in addition to gene analysis, is useful for the diagnosis of KIT-negative tumors that are suspected to be GISTs.