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World J Gastroenterol. Dec 21, 2013; 19(47): 8996-9002
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8996
Digestive cancer surgery in the era of sentinel node and epithelial-mesenchymal transition
Nadia Peparini
Nadia Peparini, Azienda Sanitaria Locale Roma H, via Mario Calo’ 5 - 00043 Ciampino, Italy, Italy
Author contributions: Peparini N conceived, drafted and revised the manuscript, and gave the final approval.
Correspondence to: Nadia Peparini, MD, PhD, Azienda Sanitaria Locale Roma H, Distretto H3, via Mario Calo’, 5 - 00043 Ciampino, Italy.
Telephone: +39-339-2203940 Fax: + 39-765-488423
Received: July 2, 2013
Revised: October 17, 2013
Accepted: November 12, 2013
Published online: December 21, 2013
Core Tip

Core tip: We summarize the current knowledge on the assessment of nodal status and nodal staging in digestive carcinomas and highlight the prognostic impact of two epithelial-mesenchymal transition-related phenomena, tumor budding and tumor deposits, that are involved in tumor progression. In light of the biological, prognostic and therapeutic impact of these phenomena, the role of staging and surgical procedures in digestive carcinoma could be reevaluated and redefined.