Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8996
Revised: October 17, 2013
Accepted: November 12, 2013
Published online: December 21, 2013
Core tip: We summarize the current knowledge on the assessment of nodal status and nodal staging in digestive carcinomas and highlight the prognostic impact of two epithelial-mesenchymal transition-related phenomena, tumor budding and tumor deposits, that are involved in tumor progression. In light of the biological, prognostic and therapeutic impact of these phenomena, the role of staging and surgical procedures in digestive carcinoma could be reevaluated and redefined.