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Topic Highlight
Current surgical treatment strategies for hepatocellular carcinoma in North America 
Adeel S Khan, Kathryn J Fowler, William C Chapman 
World J Gastroenterol 20(41):15007-15017. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15007
Linker phosphorylation of Smad3 promotes fibro-carcinogenesis in chronic viral hepatitis of hepatocellular carcinoma 
Miki Murata, Katsunori Yoshida, Takashi Yamaguchi, Koichi Matsuzaki 
World J Gastroenterol 20(41):15018-15027. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15018
Safety of hepatectomy for elderly patients with hepatocellular carcinoma 
Koichi Oishi, Toshiyuki Itamoto, Toshihiko Kohashi, Yasuhiro Matsugu, Hideki Nakahara, Mikiya Kitamoto 
World J Gastroenterol 20(41):15028-15036. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15028
Immunogenetic biomarkers in inflammatory bowel diseases: Role of the IBD3 region 
Manuel Muro, Ruth López-Hernández, Anna Mrowiec 
World J Gastroenterol 20(41):15037-15048. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15037
Prognostic and predictive response factors in colorectal cancer patients: Between hope and reality 
Chiara De Divitiis, Guglielmo Nasti, Massimo Montano, Rossella Fisichella, Rosario Vincenzo Iaffaioli, Massimiliano Berretta 
World J Gastroenterol 20(41):15049-15059. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15049
Primary prevention of colorectal cancer: Myth or reality? 
Marcela Crosara Teixeira, Maria Ignez Braghiroli, Jorge Sabbaga, Paulo M Hoff 
World J Gastroenterol 20(41):15060-15069. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15060
Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease 
Ciarán P Fisher, Andrzej M Kierzek, Nick J Plant, J Bernadette Moore 
World J Gastroenterol 20(41):15070-15078. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15070
MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease 
Nadia Panera, Daniela Gnani, Annalisa Crudele, Sara Ceccarelli, Valerio Nobili, Anna Alisi 
World J Gastroenterol 20(41):15079-15086. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15079
Hypoxia and fatty liver 
Tomohiro Suzuki, Satoko Shinjo, Takatomo Arai, Mai Kanai, Nobuhito Goda 
World J Gastroenterol 20(41):15087-15097. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15087
Prevention of esophageal strictures after endoscopic submucosal dissection 
Shinichiro Kobayashi, Nobuo Kanai, Takeshi Ohki, Ryo Takagi, Naoyuki Yamaguchi, Hajime Isomoto, Yoshiyuki Kasai, Takahiro Hosoi, Kazuhiko Nakao, Susumu Eguchi, Masakazu Yamamoto, Masayuki Yamato, Teruo Okano 
World J Gastroenterol 20(41):15098-15109. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15098
S-1 in the treatment of pancreatic cancer 
Kentaro Sudo, Kazuyoshi Nakamura, Taketo Yamaguchi 
World J Gastroenterol 20(41):15110-15118. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15110
Evolution and future of laparoscopic colorectal surgery 
Andreas M Kaiser 
World J Gastroenterol 20(41):15119-15124. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15119
Current status of laparoscopy for the treatment of rectal cancer 
Noam Shussman, Steven D Wexner 
World J Gastroenterol 20(41):15125-15134. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15125
Single-session minimally invasive management of common bile duct stones 
Ahmed AbdelRaouf ElGeidie 
World J Gastroenterol 20(41):15144-15152. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15144
Laparoscopy in the management of hilar cholangiocarcinoma 
Akihiro Cho, Hiroshi Yamamoto, Osamu Kainuma, Yorihiko Muto, Hiroo Yanagibashi, Toru Tonooka, Takahito Masuda 
World J Gastroenterol 20(41):15153-15157. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15153
Laparoscopic excision of Meckel's diverticulum in children: What is the current evidence? 
Kin Wai Edwin Chan, Kim Hung Lee, Hei Yi Vicky Wong, Siu Yan Bess Tsui, Yuen Shan Wong, Kit Yi Kristine Pang, Jennifer Wai Cheung Mou, Yuk Him Tam 
World J Gastroenterol 20(41):15158-15162. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15158
Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis 
Rafael Tojo, Adolfo Suárez, Marta G Clemente, Clara G de los Reyes-Gavilán, Abelardo Margolles, Miguel Gueimonde, Patricia Ruas-Madiedo 
World J Gastroenterol 20(41):15163-15176. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15163
Autoimmune pancreatitis in the context of IgG4-related disease: Review of imaging findings 
Leslie K Lee, Dushyant V Sahani 
World J Gastroenterol 20(41):15177-15189. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15177
Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis 
Enrico Lupia, Luca Pigozzi, Alberto Goffi, Emilio Hirsch, Giuseppe Montrucchio 
World J Gastroenterol 20(41):15190-15199. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15190
Immune-modulating therapy in acute pancreatitis: Fact or fiction 
Karolina Akinosoglou, Charalambos Gogos 
World J Gastroenterol 20(41):15200-15215. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15200
Review
Heterogeneity across the murine small and large intestine 
Rowann Bowcutt, Ruth Forman, Maria Glymenaki, Simon Richard Carding, Kathryn Jane Else, Sheena Margaret Cruickshank 
World J Gastroenterol 20(41):15216-15232. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15216
Insulin resistance and liver steatosis in chronic hepatitis C infection genotype 3 
Ludovico Abenavoli, Mario Masarone, Valentina Peta, Natasa Milic, Nazarii Kobyliak, Samir Rouabhia, Marcello Persico 
World J Gastroenterol 20(41):15233-15240. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15233
Role of endoscopic retrograde cholangiopancreatography in the management of hepatic hydatid disease 
Kemal Dolay, Sami Akbulut 
World J Gastroenterol 20(41):15253-15261. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15253
Minireviews
Sexually transmitted infections of the anus and rectum 
Roland Assi, Peter W Hashim, Vikram B Reddy, Hulda Einarsdottir, Walter E Longo 
World J Gastroenterol 20(41):15262-15268. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15262
Downregulation of signal transducer and activator of transcription 3 by sorafenib: A novel mechanism for hepatocellular carcinoma therapy 
Man-Hsin Hung, Wei-Tien Tai, Chung-Wai Shiau, Kuen-Feng Chen 
World J Gastroenterol 20(41):15269-15274. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15269
Original Article
Differential control of growth, apoptotic activity and gene expression in human colon cancer cells by extracts derived from medicinal herbs, Rhazya stricta and Zingiber officinale and their combination 
Ayman I Elkady, Rania Abd El Hamid Hussein, Osama A Abu-Zinadah 
World J Gastroenterol 20(41):15275-15288. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15275
N-acetylcysteine attenuates reactive-oxygen-species-mediated endoplasmic reticulum stress during liver ischemia-reperfusion injury 
Yong Sun, Li-Yong Pu, Ling Lu, Xue-Hao Wang, Feng Zhang, Jian-Hua Rao 
World J Gastroenterol 20(41):15289-15298. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15289
Effects of baicalin in CD4 + CD29 + T cell subsets of ulcerative colitis patients 
Feng-Yan Yu, Shao-Gang Huang, Hai-Yan Zhang, Hua Ye, Hong-Gang Chi, Ying Zou, Ru-Xi Lv, Xue-Bao Zheng 
World J Gastroenterol 20(41):15299-15309. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15299
Therapeutic effect of a hydroxynaphthoquinone fraction on dextran sulfate sodium-induced ulcerative colitis 
Zi-Liang Zhang, Hua-Ying Fan, Ming-Yan Yang, Zuo-Kai Zhang, Ke Liu 
World J Gastroenterol 20(41):15310-15318. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15310
Research Report
Beneficial effects of adenosine triphosphate-sensitive K+ channel opener on liver ischemia/reperfusion injury 
Mateus Antunes Nogueira, Ana Maria Mendonça Coelho, Sandra Nassa Sampietre, Rosely Antunes Patzina, Fabiano Pinheiro da Silva, Luiz Augusto Carneiro D'Albuquerque, Marcel Cerqueira Cesar Machado 
World J Gastroenterol 20(41):15319-15326. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15319
Intestinal ischemia-reperfusion of macaques triggers a strong innate immune response 
Hao Wu, Yi-Yun Deng, Ling Liu, Qing-Hua Tan, Chun-Hui Wang, Mei-Mei Guo, Yong-Mei Xie, Cheng-Wei Tang 
World J Gastroenterol 20(41):15327-15334. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15327
Resveratrol and genistein inhibition of rat isolated gastrointestinal contractions and related mechanisms 
Li-Xue Zhang, Hong-Fang Li, Long-De Wang, Shan Jin, Xing-Cheng Dou, Zhi-Feng Tian, Qin Ma 
World J Gastroenterol 20(41):15335-15342. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15335
Case Control Study
Elevated miR-33a and miR-224 in steatotic chronic hepatitis C liver biopsies 
Gabor Lendvai, Katalin Jármay, Gizella Karácsony, Tünde Halász, Ilona Kovalszky, Kornélia Baghy, Tibor Wittmann, Zsuzsa Schaff, András Kiss 
World J Gastroenterol 20(41):15343-15350. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15343
Resistin is not an appropriate biochemical marker to predict severity of acute pancreatitis: A case-controlled study 
Hamdi Al-Maramhy, Abdelrahman I Abdelrahman, Samer Sawalhi 
World J Gastroenterol 20(41):15351-15357. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15351
Retrospective Study
Hepatitis B vaccination in patients with inflammatory bowel disease 
Ruwaida Ben Musa, Anuhya Gampa, Sanjib Basu, Ali Keshavarzian, Garth Swanson, Michael Brown, Rana Abraham, Keith Bruninga, John Losurdo, Mark DeMeo, Sohrab Mobarhan, David Shapiro, Ece Mutlu 
World J Gastroenterol 20(41):15358-15366. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15358
Clinical Trials Study
New strategies for prevention and treatment of splenic artery steal syndrome after liver transplantation 
Ji-Yong Song, Bing-Yi Shi, Zhi-Dong Zhu, De-Hua Zheng, Gang Li, Li-Kui Feng, Lin Zhou, Tian-Tian Wu, Guo-Sheng Du 
World J Gastroenterol 20(41):15367-15373. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15367
Observational Study
Performance of the Montreal classification for inflammatory bowel diseases 
Lieke M Spekhorst, Marijn C Visschedijk, Rudi Alberts, Eleonora A Festen, Egbert-Jan van der Wouden, Gerard Dijkstra, Rinse K Weersma; Dutch Initiative on Crohn and Colitis (ICC) 
World J Gastroenterol 20(41):15374-15381. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15374
Same-day colonoscopy preparation with Senna alkaloids and bisacodyl tablets: A pilot study 
Erdinc Yenidogan, Ismail Okan, Huseyin Ayhan Kayaoglu, Gokhan Giray Akgul, Mufit Sansal, Servet Tali, Zeki Ozsoy, Mustafa Sahin 
World J Gastroenterol 20(41):15382-15386. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15382
Meta-Analysis
Effect of spleen operation on antiviral treatment in hepatitis C virus-related cirrhotic patients 
Bo Feng, Wei Zhang, Bi-Fen Luo, Guang-Jun Song, Jian Wang, Qian Jin, Hong Qin, Lai Wei 
World J Gastroenterol 20(41):15387-15397. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15387
Fish consumption and risk of gastrointestinal cancers: A meta-analysis of cohort studies 
Xiao-Feng Yu, Jian Zou, Jie Dong 
World J Gastroenterol 20(41):15398-15412. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15398
Consumption of garlic and risk of colorectal cancer: An updated meta-analysis of prospective studies 
Ji-Yi Hu, Yi-Wang Hu, Jiao-Jiao Zhou, Meng-Wen Zhang, Dan Li, Shu Zheng 
World J Gastroenterol 20(41):15413-15422. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15413
Safety of fast-track rehabilitation after gastrointestinal surgery: Systematic review and meta-analysis 
Liu-Hua Wang, Fang Fang, Chun-Ming Lu, Dao-Rong Wang, Ping Li, Ping Fu 
World J Gastroenterol 20(41):15423-15439. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15423
MiR-146a rs2910164 polymorphism increases risk of gastric cancer: A meta-analysis 
Wen-Qun Xie, Shi-Yun Tan, Xiao-Fan Wang 
World J Gastroenterol 20(41):15440-15447. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15440
Case Report
Benign giant-cell tumor of the common bile duct: A case report 
Dan-Dan Wang, Ya-Min Zheng, Liang-Hong Teng, Yan-Ni Sun, Wei Gao, Lei-Ming Wang, Yue-Hua Wang, Fei Li, De-Hong Lu 
World J Gastroenterol 20(41):15448-15453. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15448
Malignant gangliocytic paraganglioma of the duodenum with distant metastases and a lethal course 
Bin Li, Yang Li, Xiao-Ying Tian, Bo-Ning Luo, Zhi Li 
World J Gastroenterol 20(41):15454-15461. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15454
Acute diarrhea and metabolic acidosis caused by tuberculous vesico-rectal fistula 
Xiu-Qing Wei, Yan Zou, Zhi-E Wu, Kodjo-Kunale Abassa, Wei Mao, Jin Tao, Zhuang Kang, Zhuo-Fu Wen, Bin Wu 
World J Gastroenterol 20(41):15462-15466. Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15462