Immunogenetic biomarkers in inflammatory bowel diseases: Role of the IBD3 region

Figure 1 Localization of the MIC genes in the major histocompatibility complex class I region on the short arm of human chromosome six. Classical human major histocompatibility complex (MHC) class I locus (HLA-A, -B and -C), non-classical MHC (HLA-E, -F and -G) (grey boxes), and TNF-α and HFE (white box) are shown. Pseudogenes are painted in black boxes.

Figure 2 NKG2D signalling requires association with the DAP10 adapter protein. Engagement of NKG2D on NK cells [e.g., via binding of the ligand MHC class I chain-related molecule A (MICA)] can trigger cytolytic activity. It can also elicit cytokine production (e.g., MIP-1β, TNF-α and IFN-γ)[7].