Prognostic and predictive response factors in colorectal cancer patients: Between hope and reality

doi:10.3748/wjg.v20.i41.15049

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Nov 7, 2014 (publication date) through Apr 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2014; 20(41): 15049-15059
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15049

Prognostic and predictive response factors in colorectal cancer patients: Between hope and reality

Chiara De Divitiis, Guglielmo Nasti, Massimo Montano, Rossella Fisichella, Rosario Vincenzo Iaffaioli, Massimiliano Berretta

Chiara De Divitiis, Guglielmo Nasti, Massimo Montano, Rosario Vincenzo Iaffaioli, Medical Oncology, Abdominal Department, National Cancer Institute G. Pascale Foundation, 80131 Napoli, Italy

Rossella Fisichella, Department of Surgery, University of Catania, Policlinico Universitario “G. Rodolico”, 95123 Catania, Italy

Massimiliano Berretta, Department of Medical Oncology, National Cancer Institute of Aviano, 33081 Aviano, Italy

Massimiliano Berretta, Euro-Mediterranean Institute of Science and Technology (IEMEST), 90139 Palermo, Italy

Author contributions: De Divitiis C, Nasti G, Montano M, Fisichella R, Iaffaioli RV and Berretta M contributed equally to this work, designing and performing the research, and writing the paper.

Correspondence to: Massimiliano Berretta, MD, PhD, Department of Medical Oncology, National Cancer Institute of Aviano, Via Franco Gallini 2, 33081 Aviano, Italy. mberretta@cro.it

Telephone: +39-95-7179966 Fax: +39-95-3782912

Received: December 16, 2013
Revised: March 13, 2014
Accepted: August 13, 2014
Published online: November 7, 2014

Core Tip

Core tip: Colorectal cancer (CRC) represents one of the most commonly diagnosed cancers worldwide. It is the second leading cause of cancer death in Western Countries. In the last decade the survival of patients with metastatic CRC has improved dramatically. Due to the advent of new drugs and target therapies the median overall survival has risen from about 12 mo in the mid nineties to 30 mo recently. Many questions still exist regarding the prognostic factors and the predictive factors of response to therapy needing of right collocations and more clearness.