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World J Gastroenterol. Nov 7, 2014; 20(41): 15319-15326
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15319
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15319
Beneficial effects of adenosine triphosphate-sensitive K+ channel opener on liver ischemia/reperfusion injury
Mateus Antunes Nogueira, Ana Maria Mendonça Coelho, Sandra Nassa Sampietre, Rosely Antunes Patzina, Fabiano Pinheiro da Silva, Marcel Cerqueira Cesar Machado, Luiz Augusto Carneiro D’Albuquerque, Department of Gastroenterology (LIM/37), Medical School, University of Sao Paulo, Sao Paulo 01246903, Brazil
Mateus Antunes Nogueira, Ana Maria Mendonça Coelho, Sandra Nassa Sampietre, Rosely Antunes Patzina, Fabiano Pinheiro da Silva, Marcel Cerqueira Cesar Machado, Luiz Augusto Carneiro D’Albuquerque, Department of Clinical Emergency (LIM/51), Medical School, University of Sao Paulo, Sao Paulo 01246903, Brazil
Author contributions: Nogueira MA and Machado MCC designed research; Coelho AMM, Sampietre SN and Patzina RA performed research; D’Albuquerque LAC provided material and laboratory equipment, revised the manuscript; Nogueira MA, Coelho AMM, Pinheiro da Siva F and Machado MCC analyzed data; Coelho AMM and Machado MCC wrote the paper.
Supported by Fundação de Amparo à Pesquisa do Estado de São Paulo, No. 2010/19078-1
Correspondence to: Marcel Cerqueira Cesar Machado, MD, Professor of Medicine, Department of Clinical Emergency (LIM/51), Medical School, University of Sao Paulo, R. Peixoto Gomide, 515 13 andar 01409001, Sao Paulo 01246903, Brazil. mccm37@uol.com.br
Telephone: +55-11-32891188 Fax: +55-11-32891188
Received: March 28, 2014
Revised: May 28, 2014
Accepted: July 11, 2014
Published online: November 7, 2014
Revised: May 28, 2014
Accepted: July 11, 2014
Published online: November 7, 2014
Core Tip
Core tip: Diazoxide is a selective mitoKATP channel opener and has a protective effect against organ ischemia/reperfusion (I/R) injury. This report shows that diazoxide maintains liver mitochondrial function, increases liver tolerance to I/R injury, and reduces the systemic inflammatory response. Since diazoxide has also a hypotensive effect its administration may also reduce bleeding in liver surgery during hepatic parenchyma transection. These effects require further evaluation for use in a clinical setting.