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World J Gastroenterol. Nov 7, 2014; 20(41): 15079-15086
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15079
Published online Nov 7, 2014. doi: 10.3748/wjg.v20.i41.15079
MicroRNAs as controlled systems and controllers in non-alcoholic fatty liver disease
Nadia Panera, Valerio Nobili, Hepato-Metabolic Disease Unit, “Bambino Gesù” Children’s Hospital, IRCCS, 00165 Rome, Italy
Daniela Gnani, Annalisa Crudele, Sara Ceccarelli, Anna Alisi, Liver Research Unit, “Bambino Gesù” Children’s Hospital, IRCCS, 00165 Rome, Italy
Author contributions: Panera N and Alisi A contributed to the manuscript concept and design; Gnani D, Crudele A and Ceccarelli S performed the literature review and prepared the manuscript draft; Nobili V and Alisi A performed a critical revision of the manuscript.
Correspondence to: Dr. Anna Alisi, Liver Research Unit, “Bambino Gesù” Children’s Hospital, IRCCS, P.le S. Onofrio 4, 00165 Rome, Italy. anna.alisi@opbg.net
Telephone: +39-6-68592186 Fax: +39-6-68592904
Received: March 5, 2014
Revised: May 16, 2014
Accepted: June 21, 2014
Published online: November 7, 2014
Revised: May 16, 2014
Accepted: June 21, 2014
Published online: November 7, 2014
Core Tip
Core tip: Genetic background, epigenetic mechanisms and environmental factors contribute to Non-alcoholic fatty liver disease (NAFLD) development and progression. Among epigenetic mechanisms microRNAs are the most studied in NAFLD, contributing to metabolic dysfunction and liver damage. As during the last five years several authors investigated the role of microRNAs as potential therapeutic targets and/or non-invasive biomarkers we believe that this mini-review could be a good tool for researchers that critically approach this topic.